KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer

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Items 701–800 of 882

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6. Molecular profiling and mutational landscape: Possible implications in personalized medicine for treatment of pancreatic cancer
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7. The molecular evidence behind the adjunct use of anticoagulants and chemotherapy in pancreatic cancer treatment: A new role for anticoagulants?
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8. Role of Liquid-Based Cytology in the Endoscopic Diagnosis of Pancreatic Ductal Adenocarcinoma
   Koh Kitagawa, Akira Mitoro, Hisae Suzuki, Fumimasa Tomooka, Shohei Asada, Junichi Hanatani, Yuki Motokawa, Tomihiro Iwata, Yui Osaki, Maiko Takeda et al. · 2024 · Journal of Clinical Medicine
9. A Novel NRAS Variant Near the Splice Junction in Moroccan Childhood Acute Lymphoblastic Leukemia: A Molecular Dynamics Study
   Hanaa Skhoun, Meriem El Fessikh, Mohammed Khattab, Basma Mchich, Aomar Agadr, Rachid Abilkassem, Nadia Dakka, Delphine Flatters, Anne‐Claude Camproux, Zohra Ouzzif et al. · 2024 · Biochemical Genetics
10. Prognostic Properties of KRAS Gene Mutation Subtypes in Resected Pancreatic Ductal Adenocarcinoma
    Faria Nusrat, Eliyahu Gorgov, Akshay Khanna, Obehioye Isesele, Wilbur Bo Bowne, Harish Lavu, Charles J. Yeo, Wei Jiang, Aditi Jain, Avinoam Nevler · 2025 · Pancreas
11. ERK signaling promotes IKKε expression and oncogenic functions in pancreatic cancer cells in association with TBK1
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12. Evolving trends in pancreatic cancer therapeutic development
    Imani Bijou, Jin Wang · 2019 · Annals of Pancreatic Cancer
13. Malfeasance of KRAS mutations in carcinogenesis
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14. The Systematic Analysis of Exercise Mechanism in Human Diseases
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15. Gastrointestinal Tract
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16. Identification of Molecular Targets and Underlying Mechanisms of Xiaoji Recipe against Pancreatic Cancer Based on Network Pharmacology
    Cunbing Xia, Dexuan Chen, Gaoyuan Wang, Hai‐Jian Sun, Jing-Ran Lin, Chen Chen, Tong Shen, Hui Cheng, Chao Pan, Dong Xu et al. · 2022 · Computational and Mathematical Methods in Medicine · Retracted
17. The War in Ukraine: How Should Physicians and Health Physicists Communicate Radiation-related Cancer Risks to the Public?
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18. "Activated Translation of HIF-1α mRNA as a Key Mechanism in Oncogenesis of Pancreatic Ductal Adenocarcinoma and Other Malignant Diseases"
    Mitsuru Sakitani · 2023 · Biomedical Journal of Scientific & Technical Research
19. An Investigation of Point Mutations Discovers Novel Genes and Their Corresponding Motifs in Pancreatic Cancer
    Amin Ghareyazi, Amir Mohseni, Hamed Dashti, Abdollah Dehzangi, Hamid Reza Rabiee, Hamid Alinejad‐Rokny · 2021 · Preprints.org
20. Ductal Adenocarcinoma and Variants
    Eva Karamitopoulou-Diamantis · 2022 · Encyclopedia of pathology
21. Sorcin-STAT3-Serpin E1/CCL5 axis can be the trigger of pancreatic cancer-associated new-onset diabetes
    Jiali Gong, Xiawei Li, Zengyu Feng, Jianyao Lou, Kaiyue Pu, Yongji Sun, Sien Hu, Jian Wu, Yulian Wu · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
22. The molecular mechanism underlying KRAS regulation on STK31 expression in Pancreatic ductal adenocarcinoma
    Yangchao Chen, Yuting Liu, Shing Chun Tang, Ka Fai To, Bo Li, Stephen Lam Chan, Chi Hin Wong · 2023 · Research Square
23. Simultaneous Targeting of KRAS and CDK4 Synergistically Suppresses Pancreatic Cancer Cells
    Maj-Britt Paulsohn, Klara Henrike Frahnert, Xin Fang, Carolin Schneider, Constanza Tapia Contreras, Günter Schneider, Elisabeth Heßmann, Matthias Dobbelstein · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
24. Intratumoral heterogeneity in microsatellite instability at single cell resolution
    Harrison Anthony, Cathal Seoighe · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
25. Phosphoinositide 3-kinase regulates wild-type RAS signaling to confer resistance to KRAS inhibition
    Xiangyu Ge, Jaffarguriqbal Singh, Wenxue Li, Cassandra Santaella Bishop, Christian Felipe Ruiz, Moitrayee Bhattacharyya, Yansheng Liu, Mandar Deepak Muzumdar · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
26. Synthetic gene circuits that selectively target RAS-driven cancers
    Gabriel Valentin Senn, Leon Nissen, Yaakov Benenson · 2025 · eLife
27. Cancer: so common and so difficult to deal with
    Ana Santos Cravo, Randall J. Mrsny · 2020 · Elsevier eBooks
28. Improving Outcomes in Pancreatic Cancer
    Reya Sharman, Rachna T. Shroff · 2020 · touchREVIEWS in Oncology & Haematology
29. Integrin Splice Variant β4E: Characterization of a Novel Membrane Receptor in Epithelial Cancers
    Julie McGrath · 2020 · UA Campus Repository (The University of Arizona)
30. Cancer Cell Metabolism in Pancreatic Ductal Adenocarcinoma
    Hanne Røland Hagland · 2021 · Springer eBooks
31. Ras and Ras Signaling as a Therapeutic Target in Cancer
    Bailee H. Sliker, Paul M. Campbell · 2021 · Elsevier eBooks
32. Defining the KRAS-regulated kinome in KRAS-mutant pancreatic cancer
    J. Nathaniel Diehl, Jennifer E. Klomp, Kayla R. Snare, Devon R. Blake, Priya S. Hibshman, Zane D. Kaiser, Thomas S.K. Gilbert, Elisa Baldelli, Mariaelena Pierobon, Bjoern Papke et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
33. Investigating Novel Inhibitors of Epithelial - Mesenchymal Transition (EMT) and Cancer Stem Cells (CSCs) in Pancreatic Cancer
    Ruochen Dong · 2020 · KU ScholarWorks (University of Kansas)
34. iRhom2 regulates ERBB signalling to promote KRAS-driven oncogenesis
    Boris Sieber, Fangfang Lu, Stephen M. Stribbling, Adam Graham Grieve, Anderson Joseph Ryan, Matthew Freeman · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
35. Targeting Hypoxic Tumor Microenvironment in Pancreatic Cancer: An Emerging Innovative Concept
    Rinku Majumder · 2021 · Novel Approaches in Cancer Study
36. An Accurate Prognostic Model and Treatment for Pancreatic Carcinoma Based on the Tumor Immune Microenvironment
    Shujie Wang, Zhenchong Li, chunsheng liu, Qi Zhou, Zuyi Ma, Zixuan Zhou, Hongkai Zhuang, Shanzhou� Huang, Chanzhao Zhang, Baohua Hou · 2021 · Research Square
37. KRAS G12D can be targeted by potent salt-bridge forming inhibitors
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38. Genomic analyses identify biological processes of pancreatic cancer after radiotherapy
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39. Trends in pancreatic cancer clinical trials in the United States
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40. A novel role for RASSF1A in the regulation of RAS activation.
    Desmond Harrell Stewart · 2020
41. Ductal Adenocarcinoma and Variants
    Eva Karamitopoulou · 2022 · Encyclopedia of pathology
42. Peer Review #3 of "Identifying MMP14 and COL12A1 as a potential combination of prognostic biomarkers in pancreatic ductal adenocarcinoma using integrated bioinformatics analysis (v0.2)"
    2020 · PeerJ
43. Peer Review #1 of "Identifying MMP14 and COL12A1 as a potential combination of prognostic biomarkers in pancreatic ductal adenocarcinoma using integrated bioinformatics analysis (v0.1)"
    2020 · PeerJ
44. Faculty Opinions recommendation of Cell of origin influences pancreatic cancer subtype.
    Beatriz Sosa‐Pineda · 2021 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
45. Peer Review #2 of "Identifying MMP14 and COL12A1 as a potential combination of prognostic biomarkers in pancreatic ductal adenocarcinoma using integrated bioinformatics analysis (v0.1)"
    2020 · PeerJ
46. Faculty Opinions recommendation of Acidic fibroblast growth factor underlies microenvironmental regulation of MYC in pancreatic cancer.
    Nicholas R. Leslie, Laura M. Porcza · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
47. Peer Review #3 of "Identifying MMP14 and COL12A1 as a potential combination of prognostic biomarkers in pancreatic ductal adenocarcinoma using integrated bioinformatics analysis (v0.1)"
    2020 · PeerJ
48. Peer Review #1 of "Identifying MMP14 and COL12A1 as a potential combination of prognostic biomarkers in pancreatic ductal adenocarcinoma using integrated bioinformatics analysis (v0.2)"
    2020 · PeerJ
49. PKC-alpha promotes phosphorylation of KRAS suppressing its oncogenic properties
    Tejashree Joglekar, Albert Ku, Ethan Schollaert, Yi‐Nan Gong, Jacob Stewart-Ornstein, Anatoly Urisman, Man-Tzu Wang · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
50. Targeted delivery of therapeutic oligonucleotides in pancreatic cancer
    Yang Iris · 2022 · Journal of Biology and Medicine
51. Targeting a broad spectrum of KRAS -mutant cancers by hyperactivation-induced cell death
    Johanna Lilja, Jasmin Kaivola, James R. W. Conway, Joni Vuorio, Hanna Parkkola, Pekka Roivas, Taru Varila, Guillaume Jacquemet, Emilia Peuhu, Emily Wang et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
52. Selenoprotein Sepp1 regulates Cysteine Dependence in Pancreatic Cancer
    Arslan Amer, Tahiyat Alothaim, Xiaohu Tang · 2022 · Research Square
53. Molecular Biology, Genetics, and Translational Models of Human Cancer
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54. The role of dual-specificity phosphatase 6 (DUSP6) in metastasis and metabolism of pancreatic cancer cells
    Mariana T. Ruckert · 2022
55. Targeted Cancer Therapy: KRAS-Specific Treatments for Pancreatic Cancer
    Himanshi Choudhary, Luigi Emilio Xodo · 2022 · Springer eBooks
56. The Tumor Microenvironment in Pancreatic Cancer and Challenges to Immunotherapy
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57. Cancer Immunodiagnosis in Upper Gastrointestinal Cancers
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58. Explorando a quinase aurora A como alvo terapêutico em células iniciadoras de tumor pulmonares induzidas por>i< KRAS>/i<
    Luiza Coimbra Scalabrini · 2022
59. Ductal Adenocarcinoma and Pancreatic Intraepithelial Neoplasia
    2023 · American Registry of PathologyArlington, Virginia eBooks
60. Targeting Cancer Cell Signaling Using Precision Oncology Towards a Holistic Approach to Cancer Therapeutics
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61. Data from A Transcriptionally Distinct Subpopulation of Healthy Acinar Cells Exhibit Features of Pancreatic Progenitors and PDAC
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62. Data from Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules
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63. Data from Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules
    Kamini Singh, Jianan Lin, Nicolas Lecomte, Prathibha Mohan, Gokce Askan, Viraj R. Sanghvi, Man Jiang, Olivera Grbovic-Huezo, Antonija Burčul, Stefan G. Stark et al. · 2023
64. Data from Oncogene-Induced Senescence Limits the Progression of Pancreatic Neoplasia through Production of Activin A
    Yajie Zhao, Zhichong Wu, Marie Chanal, Fabienne Guillaumond, Delphine Goehrig, Sophie Bachy, Moitza Principe, Audrey Ziverec, Jean‐Michel Flaman, Guillaume Collin et al. · 2023
65. Data from Cell of Origin Influences Pancreatic Cancer Subtype
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66. Obesity and Pancreatic Cancer: Its Role in Oncogenesis
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67. Targeted Cancer Therapy: KRAS-Specific Treatments for Pancreatic Cancer
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69. Mitochondrial Quality Measures in the Regulation of Tumor Progression and Metastasis
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70. Revisiting RAS - Another Tough Nut That's Being Cracked by Cancer Research
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73. Therapeutic Targeting of KRAS Oncogene in Pancreatic Ductal Adenocarcinoma (PDAC)
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