Synthetic Lethal Vulnerabilities in KRAS-Mutant Cancers
Open accessAbstract
-mutant cancers, including the results of numerous functional genetic screens aimed at identifying KRAS synthetic lethal targets. Importantly, many of these vulnerabilities may represent tractable therapeutic opportunities.
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Genome-wide RNAi and CRISPR screens have identified many synthetic lethal partners of KRAS, many of which are druggable.
“A number of synthetic lethal genes have been identified using genome-wide RNAi and CRISPR screens, and many of these are druggable targets (32, 33).”
From KRAS mutation in pancreatic cancer (2021) · cites this paper as [33]
Inhibition of these stress-response pathways exacerbates oncogenic stress in KRAS mutant cells and impairs their viability.
“Inhibition of these pathways therefore exacerbates oncogenic stress in KRAS mutant cells and impairs their viability (32, 33).”
From KRAS mutation in pancreatic cancer (2021) · cites this paper as [33]
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References 136 · Cited by 90
- Authors
- Aguirre, A. J., & Hahn, W. C.
- Affiliations
- Broad Institute (US)
- Corresponding author
- Hahn, William C.
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2017-11-03
- Volume
- 8
- Issue
- 8
- Pages
- a031518
- ISSN
- 2157-1422 (ISSN-L)
- PMC
- PMC5990478
- OpenAlex
- W2766798501
- Cited by
- 90
- References
- 136
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 8 · 2023: 10 · 2022: 11 · 2021: 20 · 2020: 15 · 2019: 9 · 2018: 1 · 2017: 1
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Harvard Catalyst (UL1-TR-001102, TR001102)
- Hope Funds for Cancer Research
- National Institutes of Health (UL1TR001102)
- National Cancer Institute (P50CA127003, U01CA176058, P01CA154303, U01CA199253, R01CA130988)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Keywords
- KRAS mutation, synthetic lethality, functional genetic screens, KRAS-mutant cancer, cancer therapeutics, therapeutic target
- MeSH terms
- Animals, Antineoplastic Agents, Humans, Mutation, Neoplasms, Signal Transduction, Proto-Oncogene Proteins p21(ras), Cell Line, Tumor
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