The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Natural history, clinical manifestations, and pathogenesis of hepatitis A.
Open accessAbstract
Hepatitis A virus (HAV) is transmitted by the fecal-oral route and is a major cause of acute viral hepatitis. The clinical manifestations of HAV infection range from asymptomatic infection to acute liver failure (ALF), but do not include progression to chronic hepatitis. Risk factors for severe acute hepatitis A are older age (>40 years) and preexisting liver disease. Some patients may show atypical clinical features such as relapsing hepatitis, prolonged cholestasis, or extrahepatic manifestations. Almost all hepatitis A patients spontaneously recover with supportive care. However, in the case of ALF (<1%), intensive care and urgent decision on liver transplantation are required. Liver injury during hepatitis A is not directly caused by HAV but is known to be caused by immune-mediated mechanisms. In this review, the natural history and clinical manifestations of hepatitis A are described. In addition, mechanisms of immunopathogenesis in hepatitis A are discussed.
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“HAV infection has an incubation period of approximately 28 days (range: 15–50 days) (1296).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1296]
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Havelaar, A. H., Kirk, M. D., Torgerson, P. R., Gibb, H. J., Hald, T., Lake, R. J., Praet, N., Bellinger, D. C., de Silva, N. R., Gargouri, N., et al. (2015) · PLoS Medicine · doi:10.1371/journal.pmed.1001923 · Cited by 2,067 · cited 1×
“The number of global hepatitis A cases was ∼1.4 million with 27,731 deaths in 2010 (Havelaar et al. 2015).”
BackgroundInfluentialA pathogenic picornavirus acquires an envelope by hijacking cellular membranes
Feng, Z., Hensley, L., McKnight, K. L., Hu, F., Madden, V. J., Ping, L., Jeong, S., Walker, C. M., Lanford, R. E., & Lemon, S. M. (2013) · Nature · doi:10.1038/nature12029 · Cited by 712
Self-citationCuthbert, J. A. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.1.38-58.2001 · Cited by 474
Diagnosis of Hepatitis A Virus Infection: a Molecular Approach
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Immune responses and immunopathology in acute and chronic viral hepatitis
Shin, E., Sung, P. S., & Park, S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.69 · Cited by 373
Self-citationDisruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursor
Yang, Y., Liang, Y., Qu, L., Chen, Z., Yi, M., Li, K., & Lemon, S. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611506104 · Cited by 319
Hay fever and asthma in relation to markers of infection in the United States
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Hepatitis A Virus: From Discovery to Vaccines
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Is hepatitis A more severe in patients with chronic hepatitis B and other chronic liver diseases?
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Hepatitis A: Clinical Manifestations and Management
Jeong, S., & Lee, H.-S. (2010) · Intervirology · doi:10.1159/000252779 · Cited by 231
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Sexually Transmitted Infections Treatment Guidelines, 2021
Workowski, K. A., Bachmann, L. H., Chan, P. A., Johnston, C. M., Muzny, C. A., Park, I., Reno, H., Zenilman, J. M., & Bolan, G. A. (2021) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr7004a1 · Cited by 3,018
Persistence of Pathogens on Inanimate Surfaces: A Narrative Review
Wißmann, J.-E., Kirchhoff, L., Brüggemann, Y., Tödt, D., Steinmann, J., & Steinmann, E. (2021) · Microorganisms · doi:10.3390/microorganisms9020343 · Cited by 234
Lanini, S., Ustianowski, A., Pisapia, R., Zumla, A. I., & Ippolito, G. (2019) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2019.08.004 · Cited by 169
Abutaleb, A., & Kottilil, S. (2020) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2020.01.002 · Cited by 135
Cao, G., Jing, W., Liu, J., & Liu, M. (2021) · Hepatology International · doi:10.1007/s12072-021-10232-4 · Cited by 110
Metadata
- Authors
- Shin, E.-C., & Jeong, S.-H.
- Affiliations
- Korea Advanced Institute of Science and Technology (KR)
- Seoul National University (KR)
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2018-02-12
- Volume
- 8
- Issue
- 9
- Pages
- a031708
- ISSN
- 2157-1422 (ISSN-L)
- PMC
- PMC6120688
- OpenAlex
- W2785472073
- Cited by
- 170
- References
- 67
- Citations by year
- 2026: 19 · 2025: 32 · 2024: 26 · 2023: 25 · 2022: 20 · 2021: 23 · 2020: 8 · 2019: 9 · 2018: 8
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Seoul National University Bundang Hospital
- National Research Foundation (NRF-2014R1A2A1A10053662)
- Seoul National University
- Korea Institute of Science and Technology
- National Research Foundation of Korea
- Seoul National University Hospital
- Korea Advanced Institute of Science and Technology
- Topics
- Health Sciences › Medicine › Hepatology › Hepatitis Viruses Studies and Epidemiology
- Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
- Health Sciences › Medicine › Infectious Diseases › Viral gastroenteritis research and epidemiology
- Keywords
- hepatitis A virus, acute viral hepatitis, acute liver failure, fecal-oral transmission, clinical features, cholestasis, extrahepatic manifestations, immunopathogenesis, immune-mediated liver injury, liver transplantation, natural history (disease)
- MeSH terms
- Acute Disease, Hepatitis A, Humans, Liver, Risk Factors, Liver Transplantation, Liver Failure, Acute, Disease Progression, Hepatitis A Vaccines, Hepatitis A virus
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