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Notch activity induces Nodal expression and mediates the establishment of left–right asymmetry in vertebrate embryos
Open accessAbstract
Left-sided expression of Nodal in the lateral plate mesoderm is a conserved feature necessary for the establishment of normal left–right asymmetry during vertebrate embryogenesis. By using gain- and loss-of-function experiments in zebrafish and mouse, we show that the activity of the Notch pathway is necessary and sufficient for Nodal expression around the node, and for proper left–right determination. We identify Notch-responsive elements in the Nodal promoter, and unveil a direct relationship between Notch activity and Nodal expression around the node. Our findings provide evidence for a mechanism involving Notch activity that translates an initial symmetry-breaking event into asymmetric gene expression.
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Cited by
Timmerman, L. A., Grego-Bessa, J., Raya, A., Bertrán, E., Pérez-Pomares, J. M., Díez, J., Aranda, S., Palomo, S., McCormick, F., Izpisúa-Belmonte, J. C., et al. (2004) · Genes & Development · doi:10.1101/gad.276304 · Cited by 985
Self-citationHaploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants
Krebs, L. T., Shutter, J. R., Tanigaki, K., Honjo, T., Stark, K. L., & Gridley, T. (2004) · Genes & Development · doi:10.1101/gad.1239204 · Cited by 532
Calcium at Fertilization and in Early Development
Whitaker, M. (2006) · Physiological Reviews · doi:10.1152/physrev.00023.2005 · Cited by 512
Biological Physics of the Developing Embryo
Forgacs, G., & Newman, S. A. (2005) · doi:10.1017/cbo9780511755576 · Cited by 339
Tumor Cell Vasculogenic Mimicry
Seftor, R. E. B., Hess, A. R., Seftor, E. A., Kirschmann, D. A., Hardy, K. M., Margaryan, N. V., & Hendrix, M. J. C. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.07.013 · Cited by 282
Metadata
- Authors
- Raya, Á., Kawakami, Y., Rodrı́guez-Esteban, C., Büscher, D., Koth, C. M., Itoh, T., Morita, M., Raya, R. M., Dubova, I., Bessa, J. G., de la Pompa, J. L., & Belmonte, J. C. I.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2003-05-02
- Volume
- 17
- Issue
- 10
- Pages
- 1213-1218
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2162275131
- Cited by
- 182
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Notch activity induces Nodal expression and mediates the establishment of left–right asymmetry in vertebrate embryos. https://app.cochat.ai/papers/10.1101/gad.1084403
- The paper
- Raya, Á., Kawakami, Y., Rodrı́guez-Esteban, C., Büscher, D., Koth, C. M., Itoh, T., Morita, M., Raya, R. M., Dubova, I., Bessa, J. G., de la Pompa, J. L., & Belmonte, J. C. I. (2003). Notch activity induces Nodal expression and mediates the establishment of left–right asymmetry in vertebrate embryos. Genes & Development. https://doi.org/10.1101/gad.1084403
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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