The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Cooperating oncogenes converge to regulate cyclin/cdk complexes.
Open accessAbstract
The cooperation of oncogenes in the transformation of primary rat Schwann cells is a strikingly synergistic process. We have explored the molecular mechanisms involved. Activation of an inducible Raf kinase results in morphologically transformed cells that are arrested in G1 via the induction of p21(CiP1) and subsequent inhibition of cyclin/cdk activity. In contrast, coexpression of SV40 large T (LT) or a dominant-negative mutant of p53 abolishes p21(CiP1) induction and alleviates the growth arrest. Moreover in this scenario, Raf activation results in an increase in the specific activity of cyclin/cdk complexes with Raf and LT cooperating to superinduce cyclin A/cdk2 activity and stimulate proliferation in the absence of mitogens. Thus, signaling by Raf and its cooperating partners converges at the regulation of cyclin/cdk complexes, with the cellular responses to Raf modulated by p53.
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Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
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The neurofibromatosis type 1 gene encodes a protein related to GAP
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“, 2006), and occurs in a variety of cell types (Lloyd et al., 1997; Nicke et al., 2005; Denoyelle et al., 2006).”
BackgroundTumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19
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Meloche, S., & Pouysségur, J. (2007) · Oncogene · doi:10.1038/sj.onc.1210414 · Cited by 1,091
Metadata
- Authors
- Lloyd, A. C., Obermüller, F., Staddon, S., Barth, C. F., McMahon, M., & Land, H.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1997-03-01
- Volume
- 11
- Issue
- 5
- Pages
- 663-677
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2111471852
- Cited by
- 224
- References
- 5
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Lloyd, A. C., Obermüller, F., Staddon, S., Barth, C. F., McMahon, M., & Land, H. (1997). Cooperating oncogenes converge to regulate cyclin/cdk complexes. Genes & Development. https://doi.org/10.1101/gad.11.5.663
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
