The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The C/EBPβ transcription factor regulates epithelial cell proliferation and differentiation in the mammary gland
Open accessAbstract
Studies of C/EBPβ-deficient mice have demonstrated a pivotal role for this transcription factor in hematopoiesis, adipogenesis, and ovarian function. Here we show that C/EBPβ is also essential for normal development and function of the mammary gland. Ductal morphogenesis in virgin C/EBPβ-deficient mice was disrupted, with ducts displaying reduced growth and branching. To distinguish whether the effect of C/EBPβ deficiency on mammary epithelium is indirect or cell autonomous, we performed ovarian and mammary gland transplants. Transplants of wild-type ovaries into mutant females partially restored ductal morphogenesis during puberty but failed to support mammopoiesis during pregnancy. At term, mutant mice harboring wild-type ovaries exhibited reduced alveolar proliferation and impaired epithelial cell differentiation, including a complete absence of milk protein expression. Mammary gland transplant experiments demonstrated that development of C/EBPβ-deficient epithelium was defective within a wild-type stroma and host background. Cell proliferation during pregnancy was reduced and differentiation, as measured by the activity of milk protein genes, was inhibited. However, wild-type epithelium developed in a C/EBPβ-deficient stroma. Thus, C/EBPβ plays an essential, cell autonomous role in the proliferation and differentiation of mammary secretory epithelial cells and is required for the activation of milk protein genes.
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Cites
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Cao, Z., Umek, R. M., & McKnight, S. L. (1991) · Genes & Development · doi:10.1101/gad.5.9.1538 · Cited by 1,663
Impaired Energy Homeostasis in C/EBPα Knockout Mice
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Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice
Screpanti, I., Romani, L., Musiani, P., Modesti, A., Fattori, E., Lazzaro, D., Sellitto, C., Scarpa, S., Bellavia, D., & Lattanzio, G. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07185.x · Cited by 407
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Cited by
Differential Gene Regulation by the Two Progesterone Receptor Isoforms in Human Breast Cancer Cells
Richer, J. K., Jacobsen, B. M., Manning, N. G., Abel, M. G., Horwitz, K. B., & Wolf, D. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110090200 · Cited by 572
Signaling Pathways in Mammary Gland Development
Hennighausen, L., & Robinson, G. W. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00064-8 · Cited by 422
Self-citationFata, J. E., Werb, Z., & Bissell, M. J. (2003) · Breast Cancer Research · doi:10.1186/bcr634 · Cited by 383
A C/EBPβ Isoform Recruits the SWI/SNF Complex to Activate Myeloid Genes
Kowenz-Leutz, E., & Leutz, A. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80384-6 · Cited by 301
Molecular stop signs: regulation of cell-cycle arrest by C/EBP transcription factors
Johnson, P. F. (2005) · Journal of Cell Science · doi:10.1242/jcs.02459 · Cited by 288
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Metadata
- Authors
- Robinson, G. W., Johnson, P. F., Hennighausen, L., & Sterneck, E.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1998-06-15
- Volume
- 12
- Issue
- 12
- Pages
- 1907-1916
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2098974513
- Cited by
- 257
- References
- 6
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Robinson, G. W., Johnson, P. F., Hennighausen, L., & Sterneck, E. (1998). The C/EBPβ transcription factor regulates epithelial cell proliferation and differentiation in the mammary gland. Genes & Development. https://doi.org/10.1101/gad.12.12.1907
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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