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Activation of Rac1 by a Crk SH3-binding protein, DOCK180
Open accessAbstract
DOCK180 is involved in integrin signaling through CrkII-p130 Cas complexes. We have studied the involvement of DOCK180 in Rac1 signaling cascades. DOCK180 activated JNK in a manner dependent on Rac1, Cdc42Hs, and SEK, and overexpression of DOCK180 increased the amount of GTP-bound Rac1 in 293T cells. Coexpression of CrkII and p130 Cas enhanced this DOCK180-dependent activation of Rac1. Furthermore, we observed direct binding of DOCK180 to Rac1, but not to RhoA or Cdc42Hs. Dominant-negative Rac1 suppressed DOCK180-induced membrane spreading. These results strongly suggest that DOCK180 is a novel activator of Rac1 and involved in integrin signaling.
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Cited by
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Cell migration: Rho GTPases lead the way
Raftopoulou, M., & Hall, A. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2003.06.003 · Cited by 1,235
Unconventional Rac-GEF activity is mediated through the Dock180–ELMO complex
Brugnera, E., Haney, L., Grimsley, C., Lu, M., Walk, S. F., Tosello-Trampont, A.-C., Macara, I. G., Madhani, H., Fink, G. R., & Ravichandran, K. S. (2002) · Nature Cell Biology · doi:10.1038/ncb824 · Cited by 576
Gumienny, T. L., Brugnera, E., Tosello-Trampont, A.-C., Kinchen, J. M., Haney, L. B., Nishiwaki, K., Walk, S. F., Nemergut, M. E., Macara, I. G., Francis, R., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00520-7 · Cited by 568
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Metadata
- Authors
- Kiyokawa, E., Hashimoto, Y., Kobayashi, S., Sugimura, H., Kurata, T., & Matsuda, M.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1998-11-01
- Volume
- 12
- Issue
- 21
- Pages
- 3331-3336
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2100807457
- Cited by
- 430
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Activation of Rac1 by a Crk SH3-binding protein, DOCK180. https://app.cochat.ai/papers/10.1101/gad.12.21.3331
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- Kiyokawa, E., Hashimoto, Y., Kobayashi, S., Sugimura, H., Kurata, T., & Matsuda, M. (1998). Activation of Rac1 by a Crk SH3-binding protein, DOCK180. Genes & Development. https://doi.org/10.1101/gad.12.21.3331
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
