The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1
Open accessAbstract
The estrogen receptor (ER) is an important regulator of growth and differentiation of breast epithelium. Transactivation by ER depends on a leucine-rich motif, which constitutes a ligand-regulated binding site for steroid receptor coactivators (SRCs). Cyclin D1 is frequently amplified in breast cancer and can activate ER through direct binding. We show here that cyclin D1 also interacts in a ligand-independent fashion with coactivators of the SRC-1 family through a motif that resembles the leucine-rich coactivator binding motif of nuclear receptors. By acting as a bridging factor between ER and SRCs, cyclin D1 can recruit SRC-family coactivators to ER in the absence of ligand. A cyclin D1 mutant that binds to ER but fails to recruit coactivators preferentially interferes with ER activation in breast cancer cells that have high levels of cyclin D1. These data support that cyclin D1 contributes significantly to ER activation in breast cancers in which the protein is overexpressed. Our present results reveal a novel route of coactivator recruitment to ER and establish a direct role for cyclin D1 in regulation of transcription.
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Cited by
Cyclin D as a therapeutic target in cancer
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Increasing the Complexity of Coactivation in Nuclear Receptor Signaling
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Jordan, V. C. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm020449y · Cited by 414
Metadata
- Authors
- Zwijsen, R. M. L., Buckle, R. S., Hijmans, E. M., Loomans, C. J. M., & Bernards, R.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1998-11-15
- Volume
- 12
- Issue
- 22
- Pages
- 3488-3498
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2144871683
- Cited by
- 305
- References
- 53
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1. https://app.cochat.ai/papers/10.1101/gad.12.22.3488
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- Zwijsen, R. M. L., Buckle, R. S., Hijmans, E. M., Loomans, C. J. M., & Bernards, R. (1998). Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1. Genes & Development. https://doi.org/10.1101/gad.12.22.3488
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
