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Sox1 directly regulates the gamma -crystallin genes and is essential for lens development in mice
Open accessAbstract
gamma-Crystallins are major structural components of the lens fiber cells in amphibians and mammals. Many dominant inherited cataracts in humans and mice have been shown to map within the gamma-crystallin gene cluster. Several transcription factors, including PAX6 and SOX proteins, have been suggested as candidates for crystallin gene regulation. Here we show that the targeted deletion of Sox1 in mice causes microphthalmia and cataract. Mutant lens fiber cells fail to elongate, probably as a result of an almost complete absence of gamma-crystallins. It appears that the direct interaction of the SOX1 protein with a promoter element conserved in all gamma-crystallin genes is responsible for their expression.
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Cited by
Multipotent cell lineages in early mouse development depend on SOX2 function
Avilion, A. A., Nicolis, S. K., Pevny, L. H., Perez, L., Vivian, N., & Lovell-Badge, R. (2003) · Genes & Development · doi:10.1101/gad.224503 · Cited by 2,369
Self-citationPluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells
Masui, S., Nakatake, Y., Toyooka, Y., Shimosato, D., Yagi, R., Takahashi, K., Okochi, H., Okuda, A., Matoba, R., Sharov, A. A., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1589 · Cited by 1,252
From head to toes: the multiple facets of Sox proteins
Wegner, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.6.1409 · Cited by 890
Vertebrate neurogenesis is counteracted by Sox1–3 activity
Bylund, M., Andersson, E., Novitch, B. G., & Muhr, J. (2003) · Nature Neuroscience · doi:10.1038/nn1131 · Cited by 825
Depletion of definitive gut endoderm in Sox17 -null mutant mice
Kanai-Azuma, M., Kanai, Y., Gad, J. M., Tajima, Y., Taya, C., Kurohmaru, M., Sanai, Y., Yonekawa, H., Yazaki, K., Tam, P. P. L., et al. (2002) · Development · doi:10.1242/dev.129.10.2367 · Cited by 704
Metadata
- Authors
- Nishiguchi, S., Wood, H., Kondoh, H., Lovell-Badge, R., & Episkopou, V.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1998-03-15
- Volume
- 12
- Issue
- 6
- Pages
- 776-781
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2169913534
- Cited by
- 290
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Sox1 directly regulates the gamma -crystallin genes and is essential for lens development in mice. https://app.cochat.ai/papers/10.1101/gad.12.6.776
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- Nishiguchi, S., Wood, H., Kondoh, H., Lovell-Badge, R., & Episkopou, V. (1998). Sox1 directly regulates the gamma -crystallin genes and is essential for lens development in mice. Genes & Development. https://doi.org/10.1101/gad.12.6.776
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
