The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress
Open accessAbstract
Hydrogen peroxide (H2O2), a reactive oxygen species (ROS), is known to induce oxidative stress and apoptosis. U937 cells treated with H2O2 were shown to produce high molecular weight (HMW) DNA fragments approximately 50 to 100 kb in size in <1 min. The formation of these HMW DNA fragments is reversible and shown to be mediated by DNA topoisomerase II (TOP2). Following this initial event, formation of irreversible HMW DNA fragments and nucleosomal ladders occurs. Our results thus demonstrate a potential role of TOP2 in oxidative damage of DNA and apoptotic cell death.
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Citations
Cites
Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro
Imlay, J. A., Chin, S. M., & Linn, S. (1988) · Science · doi:10.1126/science.2834821 · Cited by 1,555 · cited 2×
“It appeared that either the reversal was incomplete or H2O2 also damaged chromosomal DNA via other ROS generated in cells (Imlay et al. 1988; Croteau and Bohr 1997).”
BackgroundExtrachromosomal rDNA circles—a cause of aging in yeast
Sinclair, D. A., & Guarente, L. (1997) · Cell · doi:10.1016/s0092-8674(00)80493-6 · Cited by 1,500
Cited by
c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function
Vafa, O., Wade, M., Kern, S., Beeche, M., Pandita, T. K., Hampton, G. M., & Wahl, G. M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00520-8 · Cited by 876
Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements
Haffner, M. C., Aryee, M. J., Toubaji, A., Esopi, D. M., Albadine, R., Gurel, B., Isaacs, W. B., Bova, G. S., Liu, W., Xu, J., et al. (2010) · Nature Genetics · doi:10.1038/ng.613 · Cited by 608
Who's on first in the cellular response to DNA damage?
Cline, S. D., & Hanawalt, P. C. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1101 · Cited by 129
Iron Chelators with Topoisomerase-Inhibitory Activity and Their Anticancer Applications
Rao, V. A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4877 · Cited by 37
Metadata
- Authors
- Li, T.-K., Chen, A. Y., Yu, C., Mao, Y., Wang, H., & Liu, L. F.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-06-15
- Volume
- 13
- Issue
- 12
- Pages
- 1553-1560
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2114351091
- Cited by
- 213
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress. https://app.cochat.ai/papers/10.1101/gad.13.12.1553
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- Li, T.-K., Chen, A. Y., Yu, C., Mao, Y., Wang, H., & Liu, L. F. (1999). Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress. Genes & Development. https://doi.org/10.1101/gad.13.12.1553
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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