Recruitment of the SWI/SNF chromatin remodeling complex by transcriptional activators
Open accessAbstract
SWI/SNF is a chromatin remodeling complex that facilitates expression of a number of yeast genes. Here we demonstrate that SWI/SNF can be recruited from yeast nuclear extracts by a transcriptional activator. Recruitment is dependent on an activation domain but not on promoter sequences, TBP, or RNA polymerase II holoenzyme. We also show that acidic activation domains can target SWI/SNF remodeling activity. These results demonstrate that SWI/SNF activity can be targeted by gene-specific activators and that this recruitment can occur independently of Pol II holoenzyme.
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BRM014 is a small molecule catalytic inhibitor of the ATPase activity of BRG1/BRM.
“We used the small molecule BRM014, a catalytic inhibitor of the ATPase activity of BRG1/BRM24”
From Single-molecule states link transcription factor binding to gene expression (2024) · cites this paper as [24]
The ‘Transcriptional activators can target SWI/SNF remodeling activity’ section reports that remodeling depends on ATP, but does not discuss BRM014 or inhibition of BRG1/BRM ATPase activity. Searches for ‘BRM014 catalytic inhibitor BRG1 BRM’ and ‘small molecule inhibitor ATPase activity’ found no passage addressing the claimed inhibitor. (LLM, conf=0.78)
Experimental — accuracy not yet measuredRecruitment of SWI/SNF to promoters can be mediated through sequence-specific transcription factors including Gcn4, Pho4, Swi5 and Hap4.
“Recruitment of SWI/SNF to promoters can be mediated through sequence-specific transcription factors including Gcn4, Pho4, Swi5 and Hap441,42.”
From SWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes (2022) · cites this paper as [41]
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References 37 · Cited by 241
- Authors
- Yudkovsky, N., Logie, C., Hahn, S., & Peterson, C. L.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-09-15
- Volume
- 13
- Issue
- 18
- Pages
- 2369-2374
- ISSN
- 0890-9369 (ISSN-L)
- PMC
- PMC317021
- OpenAlex
- W2149168187
- Cited by
- 241
- References
- 37
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 9 · 2023: 5 · 2022: 4 · 2021: 13 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 7 · 2016: 8 · 2015: 5 · 2014: 10 · 2013: 3 · 2012: 11
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (5r01gm042551-09)
- National Cancer Institute (T32CA009657)
- National Institute of General Medical Sciences (GM42551, R37GM049650, R01GM049650, GM496054)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- SWI/SNF complex, chromatin remodeling, transcriptional activator, transactivation domain, acidic activation domain, RNA polymerase II holoenzyme, TATA-binding protein, Saccharomyces cerevisiae
- MeSH terms
- Chromatin, DNA-Binding Proteins, Fungal Proteins, Models, Genetic, Nucleosomes, Promoter Regions, Genetic, RNA Polymerase II, Saccharomyces cerevisiae, Time Factors, Transcriptional Activation, Gene Expression Regulation, Fungal, Genes, Reporter, Holoenzymes
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