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The Escherichia coli sigma E-dependent extracytoplasmic stress response is controlled by the regulated proteolysis of an anti-sigma factor
Open accessAbstract
The activity of the stress-responsive sigma factor, sigma(E), is induced by the extracytoplasmic accumulation of misfolded or unfolded protein. The inner membrane protein RseA is the central regulatory molecule in this signal transduction cascade and acts as a sigma(E)-specific anti-sigma factor. Here we show that sigma(E) activity is primarily determined by the ratio of RseA to sigma(E). RseA is rapidly degraded in response to extracytoplasmic stress, leading to an increase in the free pool of sigma(E) and initiation of the stress response. We present evidence that the putative inner membrane serine protease, DegS, is responsible for this regulated degradation of RseA.
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Cited by
Hews, C. L., Cho, T., Rowley, G., & Raivio, T. L. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00313 · Cited by 168
Quantitative Control for Stoichiometric Protein Synthesis
Taggart, J. C., Lalanne, J.-B., & Li, G.-W. (2021) · Annual Review of Microbiology · doi:10.1146/annurev-micro-041921-012646 · Cited by 17
Corver, J., Claushuis, B., Shamorkina, T. M., de Ru, A. H., van Leeuwen, M. M., Hensbergen, P. J., & Smits, W. K. (2024) · Molecular Microbiology · doi:10.1111/mmi.15300 · Cited by 4
Metadata
- Authors
- Ades, S. E., Connolly, L. E., Alba, B. M., & Gross, C. A.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-09-15
- Volume
- 13
- Issue
- 18
- Pages
- 2449-2461
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2136139129
- Cited by
- 273
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: The Escherichia coli sigma E-dependent extracytoplasmic stress response is controlled by the regulated proteolysis of an anti-sigma factor. https://app.cochat.ai/papers/10.1101/gad.13.18.2449
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- Ades, S. E., Connolly, L. E., Alba, B. M., & Gross, C. A. (1999). The Escherichia coli sigma E-dependent extracytoplasmic stress response is controlled by the regulated proteolysis of an anti-sigma factor. Genes & Development. https://doi.org/10.1101/gad.13.18.2449
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