SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

Liu, Q., Sasaki, T., Kozieradzki, I., Wakeham, A., Itie, A., Dumont, D. J., Penninger, J. M.·1999·Genes & Development

DOI 10.1101/gad.13.7.786

Cited by (340)

Items 101–200 of 340

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SHIP deficiency causes Crohn's disease-like ileitis
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Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated phosphatidylinositol 3-kinase/Akt/GSK-3β signaling and leads to an increased transit time through the G1 phase of the cell cycle
Stefan Horn, Elmar Endl, Boris Fehse, Markus M. Weck, Georg W. Mayr, Manfred Jücker · 2004 · Leukemia
SHIP's C-terminus is essential for its hydrolysis of PIP3 and inhibition of mast cell degranulation
Jacqueline E. Damen, Mark D. Ware, Janet Kalesnikoff, Michael R. Hughes, Gerald Krystal · 2001 · Blood
Induced SHIP Deficiency Expands Myeloid Regulatory Cells and Abrogates Graft-versus-Host Disease
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Association of a transmembrane polymorphism of Fcγ receptor IIb (FCGR2B) with systemic lupus erythematosus in Taiwanese patients
Ji-Yih Chen, Chin Man Wang, Chung‐Chun Ma, Shue‐Fen Luo, Jeffrey C. Edberg, Robert P. Kimberly, Jianming Wu · 2006 · Arthritis & Rheumatism
Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease
Evelyn Tsantikos, Maverick Lau, Cassandra M.N. Castelino, Mhairi J. Maxwell, Samantha L. Passey, Michelle J. Hansen, Narelle E. McGregor, Natalie A. Sims, Daniel Steinfort, Louis B. Irving et al. · 2018 · Journal of Clinical Investigation
Src homology 2 domain–containing inositol 5-phosphatase 1 deficiency leads to a spontaneous allergic inflammation in the murine lung
Sun-Young Oh, Tao Zheng, Monica L. Bailey, Dwayne L. Barber, John T. Schroeder, Yoon‐Keun Kim, Zhou Zhu · 2006 · Journal of Allergy and Clinical Immunology
Akt–PDK1 Complex Mediates Epidermal Growth Factor-induced Membrane Protrusion through Ral Activation
Hisayoshi Yoshizaki, Naoki Mochizuki, Yukiko Gotoh, Michiyuki Matsuda · 2006 · Molecular Biology of the Cell
Downstream of Tyrosine Kinases-1 and Src Homology 2-Containing Inositol 5′-Phosphatase Are Required for Regulation of CD4+CD25+ T Cell Development
Masaki Kashiwada, Giorgio Cattoretti, Lisa McKeag, Todd M. Rouse, Brian M. Showalter, Umaima Al‐Alem, Masaru Niki, Pier Paolo Pandolfi, Elizabeth H. Field, Paul B. Rothman · 2006 · The Journal of Immunology
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miR-155 promotes FLT3-ITD–induced myeloproliferative disease through inhibition of the interferon response
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Regulation of the immune response by SHIP
Michael March, Kodi S. Ravichandran · 2002 · Seminars in Immunology
Phosphoinositide-3 kinase-PKB/Akt pathway activation is involved in fibroblast Rat-1 transformation by human T-cell leukemia virus type I tax
Yan Liu, Yin Wang, Munekazu Yamakuchi, Satoko Masuda, Takeshi Tokioka, Shoji Yamaoka, Ikuro Maruyama, Isao Kitajima · 2001 · Oncogene
Regulation of PtdIns(3,4,5)P3/Akt signalling by inositol polyphosphate 5-phosphatases
Matthew J. Eramo, Christina Anne Mitchell · 2016 · Biochemical Society Transactions
Frequency and amplitude control of cortical oscillations by phosphoinositide waves
Ding Xiong, Shengping Xiao, Su Guo, Qingsong Lin, Fubito Nakatsu, Min Wu · 2016 · Nature Chemical Biology
TEL-JAK2 Mediates Constitutive Activation of the Phosphatidylinositol 3′-Kinase/Protein Kinase B Signaling Pathway
Melody H.-H. Nguyen, Jenny Ho, Bryan K. Beattie, Dwayne L. Barber · 2001 · Journal of Biological Chemistry
Characterization of AQX ‐1125, a small‐molecule SHIP1 activator
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Hyperactivation of protein kinase B and ERK have discrete effects on survival, proliferation, and cytokine expression in Nf1-deficient myeloid cells
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Stimulation of PI 3-kinase signaling via inhibition of the tumor suppressor phosphatase, PTEN
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Modeling the regulation of p53 activation by HIF‐1 upon hypoxia
Ping Wang, Di Guan, Xiao‐Peng Zhang, Feng Liu, Wei Wang · 2019 · FEBS Letters
Essential Role for the C-Terminal Noncatalytic Region of SHIP in FcγRIIB1-Mediated Inhibitory Signaling
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PTEN and Other PtdIns(3,4,5)P3 Lipid Phosphatases in Breast Cancer
Mariah P. Csolle, Lisa M. Ooms, Antonella Papa, Christina Anne Mitchell · 2020 · International Journal of Molecular Sciences
The inositol phosphatase SHIP-1 is negatively regulated by Fli-1 and its loss accelerates leukemogenesis
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Deficiency of Src homology 2 domain–containing inositol 5-phosphatase 1 affects platelet responses and thrombus growth
Sonia Séverin, Marie‐Pierre Gratacap, Nadège Lenain, Laetitia Alvarez, ETIENNE HOLLANDE, Josef Martin Penninger, Christian Gachet, Monique M Plantavid, Bernard Payrastre · 2007 · Journal of Clinical Investigation
Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase γ
Carlotta Costa, Laura Barberis, Chiara Ambrogio, Andrea D. Manazza, Enrico Patrucco, Ornella Azzolino, Paul O. Neilsen, Elisa Ciraolo, Fiorella Altruda, Glenn D. Prestwich et al. · 2007 · Proceedings of the National Academy of Sciences
Peroxisome Proliferator Activated Receptor α Ligands as Anticancer Drugs Targeting Mitochondrial Metabolism
Maja Grabacka, Małgorzata Pierzchalska, Krzysztof Reiss · 2013 · Current Pharmaceutical Biotechnology
SHIP inhibits Akt activation in B cells through regulation of Akt membrane localization
Deborah Jeannean Carver, Mohammad Javad Aman, Kodi S. Ravichandran · 2000 · Blood
SHIP1 Negatively Regulates Proliferation of Osteoclast Precursors via Akt-Dependent Alterations in D-Type Cyclins and p27
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Discovery and Development of Small Molecule SHIP Phosphatase Modulators
Dennis R. Viernes, Lydia B. Choi, William Garrow Kerr, John D. Chisholm · 2013 · Medicinal Research Reviews
SHIP2 multiple functions: A balance between a negative control of PtdIns(3,4,5)P 3 level, a positive control of PtdIns(3,4)P 2 production, and intrinsic docking properties
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Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I α
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Genetic Segregation of Inflammatory Lung Disease and Autoimmune Disease Severity in SHIP-1−/− Mice
Mhairi J. Maxwell, Mubing Duan, Jane E. Armes, Gary P. Anderson, David Mathew Tarlinton, Margaret L. Hibbs · 2011 · The Journal of Immunology
Involvement of phosphatidylinositol 3-kinase γ in neutrophil apoptosis
Kuang‐Yao Yang, John J. Arcaroli, John Kupfner, Todd M. Pitts, Jong Sung Park, Derek Strasshiem, Reury-Perng Perng, Edward H Abraham · 2002 · Cellular Signalling
Phosphoinositide lipids in primary cilia biology
Sarah E. Conduit, Bart Vanhaesebroeck · 2020 · Biochemical Journal
SHIP deficiency enhances HSC proliferation and survival but compromises homing and repopulation
Caroline Desponts, Amy L. Hazen, Kim H.T. Paraiso, William Garrow Kerr · 2006 · Blood
Mutually inhibitory Ras-PI(3,4)P 2 feedback loops mediate cell migration
Xiaoguang Li, Marc Edwards, Kristen F. Swaney, Nilmani Singh, Sayak Bhattacharya, Jane A. Borleis, Long Yu, Pablo A. Iglesias, Jie Chen, Peter N. Devreotes · 2018 · Proceedings of the National Academy of Sciences
Src Homology 2–containing 5-Inositol Phosphatase (SHIP) Suppresses an Early Stage of Lymphoid Cell Development through Elevated Interleukin-6 Production by Myeloid Cells in Bone Marrow
Koji Nakamura, Taku Kouro, Paul W. Kincade, Alexander Malykhin, Kazuhiko Maeda, Kenneth Mark Coggeshall · 2004 · The Journal of Experimental Medicine
The SH2-domain-containing inositol 5-phosphatase (SHIP) limits neutrophil motility and wound recruitment in zebrafish
Pui‐Ying Lam, Sa Kan Yoo, Julie M. Green, Anna Huttenlocher · 2012 · Journal of Cell Science
Granulocyte colony-stimulating factor and its receptor in normal hematophoietic cell development and myeloid disease
G. J. M. van de Geijn, Lambertus H.J. Aarts, Stefan J. Erkeland, Joanna M. Prasher, L. P. Touw · 2003 · Reviews of physiology, biochemistry and pharmacology
The SH2 Inositol 5-Phosphatase Ship1 Is Recruited in an SH2-dependent Manner to the Erythropoietin Receptor
Jacqueline M. Mason, Bryan K. Beattie, Qiurong Liu, Daniel Dumont, Dwayne L. Barber · 2000 · Journal of Biological Chemistry
Murine Pancreatic Adenocarcinoma Dampens SHIP-1 Expression and Alters MDSC Homeostasis and Function
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The role of the PI3K-PKB signaling module in regulation of hematopoiesis
Miranda Buitenhuis, Paul James Coffer · 2009 · Cell Cycle
A Novel Oncogenic Role of Inositol Phosphatase SHIP2 in ER-Negative Breast Cancer Stem Cells: Involvement of JNK/Vimentin Activation
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Redox modification of Akt mediated by the dopaminergic neurotoxin MPTP, in mouse midbrain, leads to down‐regulation of pAkt
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Ming‐Jer Tang, Miho Iijima, Yoichiro Kamimura, Lingfeng Chen, Long Yu, Peter N. Devreotes · 2010 · Molecular Biology of the Cell
The Alzheimer's disease risk factor <i>INPP5D</i> restricts neuroprotective microglial responses in amyloid beta‐mediated pathology
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SHIP-1 inhibits CD95/APO-1/Fas-induced apoptosis in primary T lymphocytes and T leukemic cells by promoting CD95 glycosylation independently of its phosphatase activity
E Charlier, Claude Condé, J Zhang, Laurence Deneubourg, Emmanuel Di Valentin, Souad Rahmouni, Alain Chariot, Patrizia Agostinis, P-C Pang, Stuart M. Haslam et al. · 2010 · Leukemia
Loss of SHIP and CIS Recruitment to the Granulocyte Colony-Stimulating Factor Receptor Contribute to Hyperproliferative Responses in Severe Congenital Neutropenia/Acute Myelogenous Leukemia
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Rachel S. Salamon, Jonathan Backer · 2013 · BioEssays
Human Cytomegalovirus Induces an Atypical Activation of Akt To Stimulate the Survival of Short-Lived Monocytes
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Regulation of FcγR-stimulated phagocytosis by the 72-kDa inositol polyphosphate 5-phosphatase: SHIP1, but not the 72-kDa 5-phosphatase, regulates complement receptor 3–mediated phagocytosis by differential recruitment of these 5-phosphatases to the phagocytic cup
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SHIP Is Required for Dendritic Cell Maturation
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Ping‐Ying Pan, Junko J. Ozao, Zuping Zhou, Shu‐Hsia Chen · 2007 · Advanced Drug Delivery Reviews
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Phosphatidylinositol 3′ Kinase Signaling in Mammary Tumorigenesis
Michael P. Scheid, James Robert Woodgett · 2001 · Journal of Mammary Gland Biology and Neoplasia
CKB inhibits epithelial-mesenchymal transition and prostate cancer progression by sequestering and inhibiting AKT activation
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Leukemia-associated mutations in SHIP1 inhibit its enzymatic activity, interaction with the GM-CSF receptor and Grb2, and its ability to inactivate PI3K/AKT signaling
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Non-T Cell Activation Linker Promotes Mast Cell Survival by Dampening the Recruitment of SHIP1 by Linker for Activation of T Cells
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Positive Regulation of Interleukin-4-mediated Proliferation by the SH2-containing Inositol-5′-phosphatase
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Lineage extrinsic and intrinsic control of immunoregulatory cell numbers by SHIP
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Lyn-Dependent Signaling Regulates the Innate Immune Response by Controlling Dendritic Cell Activation of NK Cells
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Cloning of the Genomic Locus of Mouse SH2 Containing Inositol 5-Phosphatase (SHIP) and a Novel 110-kDa Splice Isoform, SHIPδ
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Adrian Martin Piliponsky, Francesca Levi‐Schaffer · 2000 · APOPTOSIS
pp60c-src associates with the SH2-containing inositol-5-phosphatase SHIP1 and is involved in its tyrosine phosphorylation downstream of αIIbβ3 integrin in human platelets
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Src Homology 2 (SH2)-Containing 5′-Inositol Phosphatase Localizes to Podosomes, and the SH2 Domain Is Implicated in the Attenuation of Bone Resorption in Osteoclasts
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