The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Symplekin and multiple other polyadenylation factors participate in 3′-end maturation of histone mRNAs
Open accessAbstract
Most metazoan messenger RNAs encoding histones are cleaved, but not polyadenylated at their 3′ ends. Processing in mammalian cell extracts requires the U7 small nuclear ribonucleoprotein (U7 snRNP) and an unidentified heat-labile factor (HLF). We describe the identification of a heat-sensitive protein complex whose integrity is required for histone pre-mRNA cleavage. It includes all five subunits of the cleavage and polyadenylation specificity factor (CPSF), two subunits of the cleavage stimulation factor (CstF), and symplekin. Reconstitution experiments reveal that symplekin, previously shown to be necessary for cytoplasmic poly(A) tail elongation and translational activation of mRNAs during Xenopus oocyte maturation, is the essential heat-labile component. Thus, a common molecular machinery contributes to the nuclear maturation of mRNAs both lacking and possessing poly(A), as well as to cytoplasmic poly(A) tail elongation.
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Wu, L., Wells, D., Tay, J., Mendis, D., Abbott, M.-A., Barnitt, A., Quinlan, E., Heynen, A., Fallon, J. R., & Richter, J. D. (1998) · Neuron · doi:10.1016/s0896-6273(00)80630-3 · Cited by 488 · cited 1×
“…of mRNAs containing a cytoplasmic polyadenylation element (CPE), a regulated process that occurs in the cytoplasm during oocyte maturation (Barnard et al. 2004), as well as during cell cycle progression (Groisman et al. 2002) and synaptic stimulation of neurons (Wu et al. 1998; Huang et al. 2002).”
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Cited by
The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones
Cech, T. R., & Steitz, J. A. (2014) · Cell · doi:10.1016/j.cell.2014.03.008 · Cited by 2,524
Self-citationNon-coding RNAs: lessons from the small nuclear and small nucleolar RNAs
Matera, A. G., Terns, R. M., & Terns, M. P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2124 · Cited by 877
Mammalian NET-Seq Reveals Genome-wide Nascent Transcription Coupled to RNA Processing
Nojima, T., Gomes, T., Grosso, A. R. F., Kimura, H., Dye, M. J., Dhir, S., Carmo-Fonseca, M., & Proudfoot, N. J. (2015) · Cell · doi:10.1016/j.cell.2015.03.027 · Cited by 562
Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease
Mandel, C. R., Kaneko, S., Zhang, H., Gebauer, D., Vethantham, V., Manley, J. L., & Tong, L. (2006) · Nature · doi:10.1038/nature05363 · Cited by 455
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Metadata
- Authors
- Kolev, N. G., & Steitz, J. A.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2005-10-17
- Volume
- 19
- Issue
- 21
- Pages
- 2583-2592
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2152470748
- Cited by
- 174
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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