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Distinct protein interaction domains and protein spreading in a complex centromere
Open accessAbstract
Fission yeast (Schizosaccharomyces pombe) centromeres are composed of large (40–100 kb) inverted repeats that display heterochromatic features, thus providing a good model for higher eukaryotic centromeres. The association of three proteins that mediate region-specific silencing across centromere 1 has been mapped by quantitative chromatin immunoprecipitation. Swi6 and Chp1 are confined to the flanking outer repeats and Swi6 can spread across at least 3 kb of extraneous chromatin in cen1. In contrast, Mis6 coats the inner repeats and central core. tRNA genes demarcate this transition zone. These analyses clearly define two distinct domains within this complex centromere which interact with different proteins.
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Cited by
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
Bannister, A. J., Zegerman, P., Partridge, J. F., Miska, E. A., Thomas, J. O., Allshire, R. C., & Kouzarides, T. (2001) · Nature · doi:10.1038/35065138 · Cited by 2,903
Self-citationRole of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly
Nakayama, J.-I., Rice, J. C., Strahl, B. D., Allis, C. D., & Grewal, S. I. S. (2001) · Science · doi:10.1126/science.1060118 · Cited by 1,739
Grewal, S. I. S., & Jia, S. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2008 · Cited by 1,263
Nasmyth, K. (2001) · Annual Review of Genetics · doi:10.1146/annurev.genet.35.102401.091334 · Cited by 805
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Gaszner, M., & Felsenfeld, G. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1925 · Cited by 649
Metadata
- Authors
- Partridge, J. F., Borgstrøm, B., & Allshire, R. C.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-04-01
- Volume
- 14
- Issue
- 7
- Pages
- 783-791
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2141764062
- Cited by
- 242
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Partridge, J. F., Borgstrøm, B., & Allshire, R. C. (2000). Distinct protein interaction domains and protein spreading in a complex centromere. Genes & Development. https://doi.org/10.1101/gad.14.7.783
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