The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
MicroRNAs as master regulators of the plant NB-LRR defense gene family via the production of phased, trans-acting siRNAs
Open accessAbstract
Legumes and many nonleguminous plants enter symbiotic interactions with microbes, and it is poorly understood how host plants respond to promote beneficial, symbiotic microbial interactions while suppressing those that are deleterious or pathogenic. Trans-acting siRNAs (tasiRNAs) negatively regulate target transcripts and are characterized by siRNAs spaced in 21-nucleotide (nt) “phased” intervals, a pattern formed by DICER-LIKE 4 (DCL4) processing. A search for phased siRNAs (phasiRNAs) found at least 114 Medicago loci, the majority of which were defense-related NB-LRR-encoding genes. We identified three highly abundant 22-nt microRNA (miRNA) families that target conserved domains in these NB-LRR s and trigger the production of trans-acting siRNAs. High levels of small RNAs were matched to >60% of all ∼540 encoded Medicago NB-LRRs; in the potato, a model for mycorrhizal interactions, phasiRNAs were also produced from NB-LRR s. DCL2 and SGS3 transcripts were also cleaved by these 22-nt miRNAs, generating phasiRNAs, suggesting synchronization between silencing and pathogen defense pathways. In addition, a new example of apparent “two-hit” phasiRNA processing was identified. Our data reveal complex tasiRNA-based regulation of NB-LRR s that potentially evolved to facilitate symbiotic interactions and demonstrate miRNAs as master regulators of a large gene family via the targeting of highly conserved, protein-coding motifs, a new paradigm for miRNA function.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
Versatile and open software for comparing large genomes
Kurtz, S., Phillippy, A., Delcher, A. L., Smoot, M., Shumway, M., Antonescu, C., & Salzberg, S. L. (2004) · Genome Biology · doi:10.1186/gb-2004-5-2-r12 · Cited by 5,254
Genome sequence of the palaeopolyploid soybean
Schmutz, J., Cannon, S. B., Schlueter, J., Ma, J., Mitros, T., Nelson, W., Hyten, D. L., Song, Q., Thelen, J. J., Cheng, J., et al. (2010) · Nature · doi:10.1038/nature08670 · Cited by 4,463
Self-citationMicroRNAs AND THEIR REGULATORY ROLES IN PLANTS
Jones-Rhoades, M. W., Bartel, D. P., & Bartel, B. (2006) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.57.032905.105218 · Cited by 2,686
microRNA-Directed Phasing during Trans-Acting siRNA Biogenesis in Plants
Allen, E., Xie, Z., Gustafson, A. M., & Carrington, J. C. (2005) · Cell · doi:10.1016/j.cell.2005.04.004 · Cited by 2,268
Genome sequence and analysis of the tuber crop potato
The Potato Genome Sequencing Consortium (2011) · Nature · doi:10.1038/nature10158 · Cited by 2,065
Aukerman, M. J., & Sakai, H. (2003) · The Plant Cell · doi:10.1105/tpc.016238 · Cited by 1,946
Genome sequencing and analysis of the model grass Brachypodium distachyon
Initiative, T. I. B. (2010) · Nature · doi:10.1038/nature08747 · Cited by 1,846
The Sequential Action of miR156 and miR172 Regulates Developmental Timing in Arabidopsis
Wu, G., Park, M. Y., Conway, S. R., Wang, J.-W., Weigel, D., & Poethig, R. S. (2009) · Cell · doi:10.1016/j.cell.2009.06.031 · Cited by 1,678
Wang, J.-W., Czech, B., & Weigel, D. (2009) · Cell · doi:10.1016/j.cell.2009.06.014 · Cited by 1,489
Cited by
The expanding world of small RNAs in plants
Borges, F., & Martienssen, R. A. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4085 · Cited by 1,016
Biosynthesis and Regulation of Phenylpropanoids in Plants
Deng, Y., & Lu, S. (2017) · Critical Reviews in Plant Sciences · doi:10.1080/07352689.2017.1402852 · Cited by 623
Disease Resistance Mechanisms in Plants
Andersen, E. J., Ali, S., Byamukama, E., Yen, Y., & Nepal, M. P. (2018) · Genes · doi:10.3390/genes9070339 · Cited by 434
Revisiting Criteria for Plant MicroRNA Annotation in the Era of Big Data
Axtell, M. J., & Meyers, B. C. (2018) · The Plant Cell · doi:10.1105/tpc.17.00851 · Cited by 429
Self-citationPlant Noncoding RNAs: Hidden Players in Development and Stress Responses
Yu, Y., Zhang, Y., Chen, X., & Chen, Y. (2019) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100818-125218 · Cited by 396
Metadata
- Authors
- Zhai, J., Jeong, D.-H., De Paoli, E., Park, S., Rosen, B. D., Li, Y., González, A. J., Yan, Z., Kitto, S. L., Grusak, M. A., Jackson, S. A., Stacey, G., Cook, D. R., Green, P. J., Sherrier, D. J., & Meyers, B. C.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2011-12-01
- Volume
- 25
- Issue
- 23
- Pages
- 2540-2553
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2011749504
- Cited by
- 684
- References
- 55
- Type
- posted content
- Language
- en
- Open access
- diamond
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: MicroRNAs as master regulators of the plant NB-LRR defense gene family via the production of phased, trans-acting siRNAs. https://app.cochat.ai/papers/10.1101/gad.177527.111
- The paper
- Zhai, J., Jeong, D.-H., De Paoli, E., Park, S., Rosen, B. D., Li, Y., González, A. J., Yan, Z., Kitto, S. L., Grusak, M. A., Jackson, S. A., Stacey, G., Cook, D. R., Green, P. J., Sherrier, D. J., & Meyers, B. C. (2011). MicroRNAs as master regulators of the plant NB-LRR defense gene family via the production of phased, trans-acting siRNAs. Genes & Development. https://doi.org/10.1101/gad.177527.111
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
