The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
A decade of 3C technologies: insights into nuclear organization
Open accessAbstract
Over the past 10 years, the development of chromosome conformation capture (3C) technology and the subsequent genomic variants thereof have enabled the analysis of nuclear organization at an unprecedented resolution and throughput. The technology relies on the original and, in hindsight, remarkably simple idea that digestion and religation of fixed chromatin in cells, followed by the quantification of ligation junctions, allows for the determination of DNA contact frequencies and insight into chromosome topology. Here we evaluate and compare the current 3C-based methods (including 4C [chromosome conformation capture-on-chip], 5C [chromosome conformation capture carbon copy], HiC, and ChIA-PET), summarize their contribution to our current understanding of genome structure, and discuss how shape influences genome function.
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BackgroundFrom Silencing to Gene Expression
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Cited by
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Metadata
- Authors
- de Wit, E., & de Laat, W.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2012-01-01
- Volume
- 26
- Issue
- 1
- Pages
- 11-24
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W1945579058
- Cited by
- 712
- References
- 16
- Type
- posted content
- Language
- en
- Open access
- diamond
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