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Cited by 160Protein Kinase Regulation and GTPase SignalingCellular transport and secretionDevelopmental Biology and Gene Regulation

Insights into the biological functions of Dock family guanine nucleotide exchange factors

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Laurin, Mélanie, Côté, Jean-François·2014·Genes & Development
DOI 10.1101/gad.236349.113PMC PMC3967044
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Abstract

Rho GTPases play key regulatory roles in many aspects of embryonic development, regulating processes such as differentiation, proliferation, morphogenesis, and migration. Two families of guanine nucleotide exchange factors (GEFs) found in metazoans, Dbl and Dock, are responsible for the spatiotemporal activation of Rac and Cdc42 proteins and their downstream signaling pathways. This review focuses on the emerging roles of the mammalian DOCK family in development and disease. We also discuss, when possible, how recent discoveries concerning the biological functions of these GEFs might be exploited for the development of novel therapeutic strategies.

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Authors
Laurin, M., & Côté, J.-F.
Affiliations
Montreal Clinical Research Institute (CA)
Corresponding author
Côté, Jean-François
ORCID
Venue
Genes & Development
Publisher
Cold Spring Harbor Laboratory
Published
2014-03-15
Volume
28
Issue
6
Pages
533-547
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
DOI
10.1101/gad.236349.113
PMC
PMC3967044
OpenAlex
W2125073987
Cited by
160
References
97
Citations by year
2026: 8 · 2025: 10 · 2024: 8 · 2023: 17 · 2022: 16 · 2021: 19 · 2020: 15 · 2019: 14 · 2018: 7 · 2017: 14 · 2016: 13 · 2015: 12 · 2014: 7
Type
posted content
Language
en
Open access
Licence
cc-by-nc
Locations
  • Genes & Development (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
  • Cancer Research Society
  • Fondation du cancer du sein du Québec
  • Canadian Institutes of Health Research (77591_2)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
guanine nucleotide exchange factor, Rho GTPases, Dbl, Rac, Cdc42, embryonic development, cell migration, morphogenesis, therapeutic target
MeSH terms
Animals, Disease, Enzyme Activation, Humans, Signal Transduction, Guanine Nucleotide Exchange Factors, rho GTP-Binding Proteins, Growth and Development, Neurogenesis

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