Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination

Gong, Fade; Chiu, Li-Ya; Cox, Ben; Aymard, François; Clouaire, Thomas; Leung, Justin W.; Cammarata, Michael; Perez, Mercedes; Agarwal, Poonam; Brodbelt, Jennifer S.; Legube, Gaëlle; Miller, Kyle M.

doi:10.1101/gad.252189.114

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination

How chromatin shapes pathways that promote genome–epigenome integrity in response to DNA damage is an issue of crucial importance. We report that human bromodomain (BRD)-containing proteins, the primary “readers” of acetylated chromatin, are vital for the DNA damage response (DDR). We discovered …