The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation.
Open accessAbstract
In mammals and other vertebrates, cytosine methylation in CpG sites is often negatively correlated with gene activity. Because methylation of the promoter region is most crucial for this effect, the simplest hypothesis is that CpG methylation interferes with the binding of specific transcription factors. We have examined this hypothesis with two different transcription factor-binding sites that contain a CpG dinucleotide, namely the cAMP-responsive element (CRE; 5'-TGACGTCA) and the Sp1-binding site (5'-GTGAGGCGGTGAGACT). We have reported previously that CpG methylation of the Sp1-binding site affected neither factor binding nor transcription in HeLa cells, which may be related to the fact that Sp1 is typically associated with promoters of housekeeping genes. In contrast, CREs are often associated with promoters of cell type-specific genes. A synthetic oligonucleotide containing two tandem CREs derived from the gene encoding the human glycoprotein hormone alpha-subunit was cloned upstream of a reporter gene. Transcription of this gene was dependent on the CRE sequences in both PC12 and HeLa cells. Bandshift and methylation interference assays show that similar, if not the same, factor(s) bind to the CRE in both cell lines, even though induction by cAMP was only observed in PC12 cells. CpG methylation of the CRE consensus sequences (TGACGTCA) resulted in loss of specific factor binding, as well as loss of transcriptional activity in vitro and in vivo, in both cell types. This suggests that the inactivity of methylated promoters can, at least in some cases, be explained by their inability to bind specific transcription factors.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The manipulation of the methylation status of DNA sequences has been shown (mostly in in vitro studies) to result in the differential binding of TFs, including E2F, AP2α, MYC and MYN88–95.”
From Transcription factors as readers and effectors of DNA methylation (2016) · cites this paper as [92]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Dignam, J. D., Lebovitz, R. M., & Roeder, R. G. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.5.1475 · Cited by 11,262
A new technique for the assay of infectivity of human adenovirus 5 DNA
Graham, F. L., & van der Eb, A. J. (1973) · Virology · doi:10.1016/0042-6822(73)90341-3 · Cited by 9,302
CpG-rich islands and the function of DNA methylation
Bird, A. P. (1986) · Nature · doi:10.1038/321209a0 · Cited by 3,777
CpG Islands in vertebrate genomes
Gardiner‐Garden, M., & Frommer, M. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90689-9 · Cited by 3,417
PROTEIN SERINE/THREONINE KINASES
Edelman, A. M., Blumenthal, D., & Krebs, E. G. (1987) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.56.070187.003031 · Cited by 1,435
Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene
Montminy, M., & Bilezikjian, L. M. (1987) · Nature · doi:10.1038/328175a0 · Cited by 1,390
Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB
Yamamoto, K. K., Gonzalez, G. A., Biggs, W., & Montminy, M. (1988) · Nature · doi:10.1038/334494a0 · Cited by 1,281
DNA METHYLATION AND GENE ACTIVITY
Doerfler, W. (1983) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.52.070183.000521 · Cited by 1,094
Cyclic AMP and the induction of eukaryotic gene transcription.
Roesler, W. J., Vandenbark, G. R., & Hanson, R. W. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)76506-5 · Cited by 1,036
DNA methylation and gene activity
Cedar, H. (1988) · Cell · doi:10.1016/0092-8674(88)90479-5 · Cited by 907
Flagged first, then by citations
Research works printed but not linked: 3
- Cristy, B.A. and G.A. Scangos. 1986. Control of gene expression by DNA methylation. In Molecular genetics of mammalian cells (ed. G.M. Malacinski), pp. 3–29, Macmillan, New York.
- de Villiers, J. and W. Schaffner. 1983. Transcriptional ‘enhancers’ from papovaviruses as components of eukaryotic expression vectors. In Techniques in the life sciences, B5. Nucleic Acid Biochemistry, Elsevier, Ireland.
- Parker, J.-H., H.V. Hershey, and M.W. Taylor. 1986. House-keeping genes. In Molecular genetics of mammalian cells (ed. G.M. Malacinski), pp. 79–98, Macmillan, New York.
Cited by
Sorted by citations
Items 401–500 of 556
Deciphering the dynamic code: DNA recognition by transcription factors in the ever-changing genome
Yao, Y. M., Miodownik, I., O’Hagan, M., Jbara, M., & Afek, A. (2024) · Transcription · doi:10.1080/21541264.2024.2379161 · Cited by 12
Santos, F. G. D. A., Sum, H., Yan, D. C. L., & Brewer, A. C. (2025) · Cells · doi:10.3390/cells14050378 · Cited by 13
Ghosh, S., Karmakar, S., Banerjee, S., Biswas, S., Mukherjee, U., Das, S., Samanta, A., & Maitra, S. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.126779 · Cited by 12
Moraru, A., de Almeida, M. M., & Degryse, J. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15050857 · Cited by 12
Human CATSPER1 Promoter Is Regulated by CREB1 and CREMτ Transcriptional Factors In Vitro
Oviedo, N., Ortiz-Borrayo, L., Hernández‐Sánchez, J., Jiménez-Badillo, S. E., Tesoro-Cruz, E., Moreno-Navor, E., Aguirre-Alvarado, C., & Méndez, V. C. B. (2018) · Archives of Medical Research · doi:10.1016/j.arcmed.2018.06.004 · Cited by 12
Kim, T. W., Han, S. R., Kim, J., Yoo, S., Lee, M., Lee, S., Kang, Y. H., & Lee, H. Y. (2019) · Oncology Reports · doi:10.3892/or.2019.7099 · Cited by 12
Christman, J. K. (1995) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-1957-7_13 · Cited by 12
Clifford, C. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00058-3 · Cited by 12
Methylation-dependent and -independent DNA binding of nuclear factor EF-C
García, A. D., Ostapchuk, P., & Hearing, P. (1991) · Virology · doi:10.1016/0042-6822(91)90629-p · Cited by 12
Allaman-Pillet, N., DJEMAÏ, A., Bonny, C., & Schorderet, D. F. (1998) · Europe PMC (PubMed Central) · Cited by 12
Bruhat, A. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.10.1816 · Cited by 12
Li, Y., Ohms, S., Shannon, F. M., Sun, C., & Fan, J. Y. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.02.094 · Cited by 11
Marx, A., Kahan, T., & Simon, I. (2013) · BioMed Research International · doi:10.1155/2013/785731 · Cited by 11
Liu, Y., Wang, M., Jiang, S., Lu, Y., Tao, D., Yang, Y., Ma, Y., & Zhang, S. (2014) · BMB Reports · doi:10.5483/bmbrep.2014.47.2.066 · Cited by 11
Khan, A. W., Corcoran, S. J., Esler, M., & El-Osta, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.015 · Cited by 11
Badia, É., Duchesne, M., Nicolas, J., & Pons, M. (1998) · Breast Cancer Research and Treatment · doi:10.1023/a:1005801005966 · Cited by 11
Faber, S. M., Ip, T., Granner, D. K., & Chalkley, R. G. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.17.4681 · Cited by 11
Pan, X., Bowman, M. E., Scott, R. J., Fitter, J. T., Nicholson, R. C., Smith, R., & Zakár, T. (2015) · International Journal of Endocrinology · doi:10.1155/2015/861302 · Cited by 10
Dasmahapatra, A. K., & Khan, I. A. (2015) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2015.10.011 · Cited by 10
Follistatin treatment modifies DNA methylation of the CDX2 gene in bovine preimplantation embryos
Ashry, M., Rajput, S. K., Folger, J. K., Yang, C., Knott, J. G., & Smith, G. W. (2020) · Molecular Reproduction and Development · doi:10.1002/mrd.23409 · Cited by 10
Arora, D., Park, J., Lim, D., Choi, B., Cho, I., Srikanth, K., Kim, J., & Park, W. (2021) · BMC Genomics · doi:10.1186/s12864-021-08123-x · Cited by 10
The promoter analysis of the human C17orf25 gene, a novel chromosome 17p13.3 gene
Guo, J. Y., Xu, J., Mao, D. Q., Li Li, F. U., Gu, J. R., & Zhu, J. (2002) · Cell Research · doi:10.1038/sj.cr.7290136 · Cited by 10
Effect of Regulatory Element DNA Methylation on Tissue-Type Plasminogen Activator Gene Expression
Dunoyer-Geindre, S., Rivier-Cordey, A.-S., Caetano, C. E. R., Fish, R. J., & Kruithof, E. K. O. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167588 · Cited by 10
DNA methylation differences in monozygotic twins with Van der Woude syndrome
Petrin, A. L., Zeng, E., Thomas, M. A., Moretti‐Ferreira, D., Marazita, M. L., Xie, X., Murray, J. C., & Moreno-Uribe, L. M. (2023) · Frontiers in Dental Medicine · doi:10.3389/fdmed.2023.1120948 · Cited by 9
A review on regulation of DNA methylation during post-myocardial infarction
Han, W., Wang, W., Wang, Q., Maduray, K., Li, H., & Zhong, J. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1267585 · Cited by 12
DNA Methylation and retrovirus expression
Bednarik, D. P. (1993) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-9118-9_13 · Cited by 9
Burnett, E., & Tattersall, P. J. (2003) · Journal of Virology · doi:10.1128/jvi.77.16.8650-8660.2003 · Cited by 9
Paglino, J. C., Burnett, E., & Tattersall, P. J. (2006) · Virology · doi:10.1016/j.virol.2006.11.006 · Cited by 9
Presnell, S. R., Zhang, L., Chlebowy, C. N., Al‐Attar, A., & Lutz, C. T. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103352 · Cited by 9
Chyan, Y.-J., Rawson, T. Y., & Wilson, S. H. (2003) · Gene · doi:10.1016/s0378-1119(03)00607-3 · Cited by 9
Schübeler, D., Lorincz, M. C., & Groudine, M. T. (2001) · Science s STKE · doi:10.1126/stke.2001.83.pl1 · Cited by 9
DNA Methylation Represses the Murine αl (I) Collagen Promoter by an Indirect Mechanism
Rhodes, K., Rippe, R. A., Umezawa, A., Nehls, M. C., Brenner, D. A., & Breindl, M. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.5950-5960.1994 · Cited by 9
Zheng, J., Zhu, Q., & Högstrand, C. (2023) · Aquatic Toxicology · doi:10.1016/j.aquatox.2023.106605 · Cited by 8
Kumar, S., Shanker, O. R., Banerjee, J., Tripathi, M., Chandra, P. S., & Dixit, A. B. (2023) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2023.01.005 · Cited by 8
Gene expression patterns in a rodent model for depression
Lagus, M., Gass, N., Saharinen, J., Saarela, J., Porkka‐Heiskanen, T., & Paunio, T. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07166.x · Cited by 8
Li, Z., Chen, L., Lai, Y.-H., Dai, Z., & Zou, X. (2013) · Analytical Methods · doi:10.1039/c3ay41962b · Cited by 8
Breaking the Silence: The Interplay Between Transcription Factors and DNA Methylation
Baron, B. (2012) · InTech eBooks · doi:10.5772/55021 · Cited by 9
Miyasaka, N., Hatanaka, Y., Jin, M., & Arimatsu, Y. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00107-2 · Cited by 8
PRG-1 transcriptional regulation independent from Nex1/Math2-mediated activation
Geist, B., Vorwerk, B., Coiro, P., Ninnemann, O., & Nitsch, R. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0774-7 · Cited by 7
Epigenetic reorganization during early embryonic lineage specification
Fang, H., Luo, Z., & Lin, C. (2022) · Genes & Genomics · doi:10.1007/s13258-021-01213-w · Cited by 7
cAMP responsive element modulator α promotes effector T cells in systemic autoimmune diseases
Carlsson, E., Cowell‐McGlory, T., & Hedrich, C. M. (2023) · Immunology · doi:10.1111/imm.13680 · Cited by 7
Epigenetic Mechanisms in the Pathophysiology of Psychotic Disorders
Ruzicka, W. B. (2015) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000048 · Cited by 7
Yang, S., Yang, X., Yao, L., Wang, H., & Sun, C.-K. (2011) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2011.03.003 · Cited by 7
Romero-Tlalolini, M. D. L. Á., Chávez-Olmos, P., & Garrido, E. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.07.023 · Cited by 7
Thomas, L. R., & Tansey, W. P. (2015) · The Open Access Journal of Science and Technology · doi:10.11131/2015/101124 · Cited by 7
Lack of a consistent relationship between demethylation of the CD44 promoter and CD44 expression
Hyman, R. (2002) · Immunogenetics · doi:10.1007/s00251-001-0417-5 · Cited by 7
A Tobacco Nuclear Protein that Preferentially Binds to Unmethylated CpG‐rich DNA
Fisscher, U., Weisbeek, P. J., & SMEEKENS, S. C. M. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.00585.x · Cited by 7
Partial Purification of a Pea Seed DNA-Binding Protein That Specifically Recognizes 5-MethyIcytosine
Ehrlich, K. (1993) · Preparative Biochemistry · doi:10.1080/10826069308544567 · Cited by 7
Rovirosa, L., Ramos-Morales, A., & Javierre, B. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.592087 · Cited by 5
Lejart, A., Zentout, S., Chapuis, C., D’Augustin, O., Smith, R., Salbert, G., & Huet, S. (2022) · Chromosoma · doi:10.1007/s00412-022-00769-0 · Cited by 7
Dahodwala, H., Amenyah, S., Nicoletti, S., Henry, M. N., Lees‐Murdock, D. J., & Sharfstein, S. T. (2022) · Antibody Therapeutics · doi:10.1093/abt/tbac010 · Cited by 6
Tobacco use modify exon IV BDNF gene methylation levels in depression
Quaioto, B. R., Borçoi, A. R., Mendes, S. O., Doblas, P. C., Vieira, T. D. S., Moreno, I. A. A., dos Santos, J. G., Hollais, A. W., Olinda, A. S., de Souza, M. L. M., et al. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.01.038 · Cited by 7
Cilkiz, K. Z., Baker, E. C., Riggs, P. K., Littlejohn, B. P., Long, C. R., Welsh, T. H., Randel, R. D., & Riley, D. G. (2020) · Epigenetics · doi:10.1080/15592294.2020.1805694 · Cited by 8
The CREB transcription factor and processes of memory formation
Дубынина, Е. В., & Dolotov, O. V. (2009) · Neurochemical Journal · doi:10.1134/s1819712409030015 · Cited by 6
Modulation of DNA Methylation for the Treatment and Prevention of Cancer
Schrump, D. S. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-767-3_42 · Cited by 6
DNA substrate specificity of pea DNA methylase
Houlston, C. E., Cummings, M., Lindsay, H. L., Pradhan, S., & Adams, R. L. P. (1993) · Biochemical Journal · doi:10.1042/bj2930617 · Cited by 6
Pan, X., Bowman, M. E., Scott, R. J., Fitter, J. T., Smith, R., & Zakár, T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170671 · Cited by 5
Hernández‐Vargas, H., Goldsmith, C., Mathot, P., & Dante, R. (2019) · Epigenetics · doi:10.1080/15592294.2019.1699893 · Cited by 5
Maternal Epigenetic Inheritance and Stress During Gestation
Kosten, T. A., & Nielsen, D. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405944-3.00016-7 · Cited by 5
Hengst-Zhang, J. A., & Weitzman, S. A. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)81578-5 · Cited by 5
Promoter demethylation mediates the expression of ZNF645, a novel cancer/testis gene
Bai, G., Liu, Y., Zhang, H., Su, D., Tao, D., Yang, Y., Ma, Y., & Zhang, S. (2010) · BMB Reports · doi:10.3858/bmbrep.2010.43.6.400 · Cited by 5
Reeben, M., Myöhänen, S., Saarma, M., & Prydz, H. (1995) · Gene · doi:10.1016/0378-1119(95)00084-j · Cited by 5
Hypomethylation of MHC class II Eb gene is associated with expression
Scholl, T., Pitcock, A., & Jones, B. (1992) · Immunogenetics · doi:10.1007/bf00215056 · Cited by 5
Developmental and activity‐dependent genomic occupancy profiles of CREB in monkey area V1
Lalonde, J., Lachance, P. E. D., & Chaudhuri, A. (2008) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2008.00450.x · Cited by 5
The bZIP mutant CEBPB (V285A) has sequence specific DNA binding propensities similar to CREB1
Ray, S., Ufot, A., Assad, N., Singh, J., Durell, S. R., Porollo, A., Tillo, D., & Vinson, C. (2019) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2019.02.002 · Cited by 4
Fabrication of duplex DNA microarrays incorporating methyl-5-cytosine
Warren, C. L., Zhao, J., Glass, K., Rishi, V., Ansari, A. Z., & Vinson, C. (2011) · Lab on a Chip · doi:10.1039/c1lc20698b · Cited by 4
Bringing the Signal into the Nucleus
Kramer, I. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-394803-8.00007-3 · Cited by 4
Chemical Carcinogenesis and Epigenetics
Darwanto, A., Ornam, J. D. V., Lao, V. V., & Sowers, L. C. (2010) · Humana Press eBooks · doi:10.1007/978-1-61737-995-6_12 · Cited by 4
ELMALEH, N., Matthias, P., & Schaffner, W. (1990) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1990.tb15332.x · Cited by 4
Self-citationADAMS, R. L. P., Knowler, J. T., & Leader, D. P. (1992) · Springer eBooks · doi:10.1007/978-94-011-2290-0_10 · Cited by 4
Chu, C., & Shen, C. ‐. J. (1993) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-9118-9_17 · Cited by 4
Epigenetic impact of chronic stress: BDNF exon IV gene methylation in high-risk professionals
Quaioto, B. R., de Souza, M. L. M., Borçoi, A. R., Mendes, S. O., Neto, L. C. B. S., Corrêa, C. H. P., Moreno, I. A. A., Olinda, A. S., Cunha, E. R., da Silva, P. A. V., et al. (2025) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.06.018 · Cited by 3
Nerlich, A. G., Janze, N., & Goethe, R. (2021) · Genes and Immunity · doi:10.1038/s41435-021-00153-5 · Cited by 3
The Putative Promoters of Germ Cell-specific Genes and Nanog are Hypomethylated in Chicken Sperm
Kito, G., Tanaka, H., Soh, T., Yamauchi, N., & Hattori, M. (2014) · Journal of Reproduction and Development · doi:10.1262/jrd.2014-010 · Cited by 3
Ito, K., Tsutsumi, R., Ishikawa, K., & Tsutsumi, K.-I. (1995) · Developmental Genetics · doi:10.1002/dvg.1020170404 · Cited by 3
From aging to cancer: a DNA methylation journey
Martínez, N. P., & Agrelo, R. (2012) · Ageing Research · doi:10.4081/ar.2012.e4 · Cited by 3
Ushijima, H., Maekawa, R., Igarashi, E., & Akashi, S. (2019) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-019-02304-5 · Cited by 3
Kobow, K., & Khan, N. (2024) · Oxford University Press eBooks · doi:10.1093/med/9780197549469.003.0035 · Cited by 2
RECAP-seq: restriction enzyme-based CpG-methylated fragment amplification for early cancer detection
Shin, D., Kim, T., Lee, J., Kim, H., Kim, T., & Bang, D. (2025) · Scientific Reports · doi:10.1038/s41598-025-24708-y · Cited by 2
Daniel, P., Balušíková, K., Václavíková, R., Šeborová, K., Ransdorfová, Š., Valerianova, M., Wei, L., Jelínek, M., Tlapáková, T., Fleischer, T., et al. (2023) · Genes · doi:10.3390/genes14020296 · Cited by 2
Dose-related effects of Quercetin in the human breast carcinoma MCF-7 cell line
Blessing, E. (2010) · Cited by 2
Epigenetics and Regeneration: An Overview
Palacios, D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814879-2.00001-7 · Cited by 2
Müller, N., Ponkkonen, E., Carell, T., & Khobta, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011025 · Cited by 2
Kannaiyan, J., Veeramanikandan, V., Muthukumarasamy, E., & Balaji, P. (2018) · Journal of Stem Cell Research & Therapeutics · doi:10.15406/jsrt.2018.04.00124 · Cited by 2
Schübeler, D., Lorincz, M. C., & Groudine, M. T. (2001) · Science Signaling · doi:10.1126/scisignal.832001pl1 · Cited by 2
Genetic Engineering of Plant Cells
Kahl, G., & Weising, K. (2001) · Biotechnology Set · doi:10.1002/9783527620999.ch15a · Cited by 2
Maity, S. (2014) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3ff3m760 · Cited by 2
Evaluating The Infinium Human MethylationEPIC v2 BeadChipPreprint
Kaur, D., Lee, S., Goldberg, D., Spix, N. J., Hinoue, T., Li, H., Dwaraka, V. B., Smith, R. C., Shen, H., Liang, G., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2781268/v1 · Cited by 2
Regulation of maize Ac/Ds transposition by replication and DNA methylation
Ros, F. (2001) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.66 · Cited by 2
Focher, F., Mazzarello, P., Verri, A., Biamonti, G., & Spadari, S. (1992) · Springer eBooks · doi:10.1007/978-3-642-85789-8_2 · Cited by 2
Perecin, F. (2007) · Americanae (AECID Library) · Cited by 2
Upton, B. A., Krolick, K. N., Zhang, X., Pilipenko, V. V., Martin, L. J., Ji, H., Glynn, S. M., Barnett, K., Ganesh, A., Monitto, C. L., et al. (2024) · PAIN Reports · doi:10.1097/pr9.0000000000001201 · Cited by 1
Gene-Specific Hypermethylation in Aging
Akintola, A. D., & Parrish, A. R. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0639-7_3 · Cited by 1
Epigenetic Factors in Normal and Pathological Neuronal Development
Broucqsault, N., Badja, C., Gaillard, M.-C., & Magdinier, F. (2014) · Neuromethods · doi:10.1007/978-1-4939-2250-5_7 · Cited by 1
The Intrinsic Role of Epigenetics in Axonal Regeneration
Palacios, D., & Viscomi, M. T. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814879-2.00015-7 · Cited by 1
Breast Cancer Epigenetics: Biomarkers and Therapeutic Potential
Nabilsi, N. H., Pardo, C. E., Zajac‐Kaye, M., & Kladde, M. P. (2013) · Humana Press eBooks · doi:10.1007/978-1-62703-634-4_11 · Cited by 1
Mechanisms of Epigenetic Gene Silencing
Lambert, M.-P., & Herceg, Z. (2011) · Springer eBooks · doi:10.1007/978-1-84882-644-1_3 · Cited by 1
Sasagawa, T., Nagamatsu, T., & Shibuya, M. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113500 · Cited by 1
Kumar, R., & Sharan, N. (2011) · Internet Journal of Medical Update - EJOURNAL · doi:10.4314/ijmu.v6i1.63977 · Cited by 1
Epigenetics of Memory Processes
Hawkins, K. E., & Sweatt, J. D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805388-1.00023-7 · Cited by 2
Metadata
- Authors
- Iguchi-Ariga, S. M., & Schaffner, W.
- Affiliations
- University of Zurich (CH)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1989-05
- Volume
- 3
- Issue
- 5
- Pages
- 612-619
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2153782423
- Cited by
- 559
- References
- 32
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 10 · 2023: 11 · 2022: 14 · 2021: 11 · 2020: 11 · 2019: 15 · 2018: 12 · 2017: 15 · 2016: 18 · 2015: 14 · 2014: 20 · 2013: 19 · 2012: 20
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Keywords
- CpG methylation, cAMP response element, Sp1 binding site, transcription factor binding, transcriptional activation, promoter methylation, gene silencing, glycoprotein hormone alpha-subunit, PC12 cells, HeLa cells, methylation interference, cAMP signaling
- MeSH terms
- Cyclic AMP, Base Sequence, Binding Sites, Cells, Cultured, DNA, DNA-Binding Proteins, Enhancer Elements, Genetic, HeLa Cells, Humans, Methylation, Molecular Sequence Data, Promoter Regions, Genetic, Transcription, Genetic, Dinucleoside Phosphates
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
