A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73

Asher, Gad, Tsvetkov, Peter, Kahana, Chaim, Shaul, Yosef·2005·Genes & Development
DOI 10.1101/gad.319905

Cited by (370)

Items 301–370 of 370

  1. Irradiation-induced p53 expression is attenuated in cells with NQO1 C465T polymorphism.
    Masaki Sato, Masatoshi Takagi, Shuki Mizutani · 2010 · PubMed
  2. The active ingredient of Ginkgo biloba extract (quercetin) improved H2O2-induced microglia injury by activating NQO1-PI3K/Akt/mTOR signaling
    Jingchi Sun, Zhousong Zheng · 2025 · In Vitro Cellular & Developmental Biology - Animal
  3. Identification of novel NAD(P)H dehydrogenase [quinone] 1 antagonist using computational approaches
    R. Selvakumar, Anantha Krishnan Dhanabalan, C. V. Ramakrishnan, Devadasan Velmurugan, K. Gunasekaran · 2019 · Journal of Biomolecular Structure and Dynamics
  4. Upregulation of p53 by tannic acid treatment suppresses the proliferation of human colorectal carcinoma
    Serdar Karakurt, Sınan Kandır, Çiğdem Gökçek-Saraç · 2021 · Acta Pharmaceutica
  5. Identification of Novel Regulators of Zalcitabine-Induced Neuropathic Pain
    Antón Leandro Martínez, Jose Manuel Brea, Eduardo Domínguez, María José Varela, Marta Cimadevila, Catarina Allegue, Raquel Cruz, Xavier Monroy, Manuel Merlos, Javier Burgueño et al. · 2021 · ACS Chemical Neuroscience
  6. Minimized sample consumption for time-resolved serial crystallography applied to the redox cycle of human NQO1
    Diandra Doppler, Alice Grieco, Domin Koh, Abhik Manna, Adil Ansari, Roberto C. Alvarez, Konstantinos Karpos, Hung Le, Mukul Sonker, Gihan K. Ketawala et al. · 2026 · Communications Chemistry
  7. Studying Protein–Protein Interactions by Combining Native Mass Spectrometry and Chemical Cross‐Linking
    Michal Sharon, Andrea Sinz · 2015 · Wiley eBooks
  8. Exploiting the Proteasome for Disease Treatment
    Gwen R. Buel, Xiuxiu Lu, Kylie J. Walters · 2022 · Wiley eBooks
  9. Molecular regulation of PGC-1α: from protein-protein interactions and post-translational modifications to pharmacological modulation
    William Q. Rios, Carlos M. Silva, Rita M. Ferreira, José R. B. Gomes · 2026 · Journal of Molecular Medicine
  10. Frequency switching between oscillatory homeostats and the regulation of p53
    Peter Ruoff, Nobuaki Nishiyama · 2020 · PLoS ONE
  11. Metabolic Profiling of Inga Species with Antitumor Activity
    Nerilson Marques Lima, Gagan Preet, Sara Regina de Marqui, T. O. R. Falcoski, Geovana Navegante, Christiane Pienna Soares, Teresinha de Jesus A. S. Andrade, Felipe A. La Porta, Liva Harinantenaina, Marcel Jaspars et al. · 2022 · Molecules
  12. Ubiquitin-Independent Degradation of Proteins in Proteasomes
    О.А. Бунеева, A. E. Medvedev · 2018 · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry
  13. Ubiquitin‐Independent Mechanisms of Substrate Recognition and Degradation by the Proteasome
    Martin A. Hoyt, Philip Coffino · 2007 · Wiley eBooks
  14. Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry
    Maribel Rivero, Juan Luis Pacheco‐García, Pavla Vaňková, Dmitry S. Loginov, Isabel Quereda‐Moraleda, Jose Manuel Martin-Garcia, Petr Man, Angel Luis Pey, Milagros Medina · 2026 · FEBS Journal
  15. Synthetic Biology Approaches to Posttranslational Regulation in Plants
    Inna A. Abdeeva, Yulia S. Panina, Liliya G. Maloshenok · 2024 · Biochemistry (Moscow)
  16. The c-Abl/YAP/p73 Apoptotic Module and the HIPPO Pathway
    Nina Bacher Reuven, Yosef Shaul · 2013 · Springer eBooks
  17. ATP independent proteasomal degradation of NQO1 in BL cell lines
    Emanuele Salvatore Scarpa, Laura Bonfili, Anna Maria Eleuteri, Anna La Teana, Francesca Brugè, Enrico Bertoli, Gian Paolo Littarru, Tiziana Cacciamani · 2012 · Biochimie
  18. Hypothesis
    Arsalan Azimi, Arian Azimi · 2017 · Anti-Cancer Drugs
  19. Targeting HIF-1α Function in Cancer through the Chaperone Action of NQO1
    EDUARDO C. SALIDO, David J. Timson, Isabel Betancor-Fernández, Rogelio Palomino‐Morales, Angel Luis Pey · 2020 · Preprints.org
  20. Ubiquitin‐Independent Mechanisms of Substrate Recognition and Degradation by the Proteasome
    Martin A. Hoyt, Philip Coffino · 2007 · Wiley eBooks
  21. Pharmacogenomic analysis and clinical annotation of 635 patients
    Özkan Bağcı, Batuhan Şanlıtürk, Ebru Marzioğlu Özdemir, Nadir Koçak, Tülin Çora · 2025 · Personalized Medicine
  22. PPM1D is directly degraded by proteasomes in a ubiquitination-independent manner through its carboxyl-terminal region
    Masaki Takahashi, Takeshi Kondo, Shogo Kimura, Akira Nakazono, Shusei Yoshida, Takeshi Wada, Masashi Watanabe, Shigetsugu Hatakeyama · 2025 · Journal of Biomedical Science
  23. NQO1 at the crossroads of oxidative stress, cancer, and therapeutic innovation
    Meagan Marie Ybarra, Addanki P. Kumar, Rita Ghosh · 2026 · Biochemical Pharmacology
  24. Release the ink4a/arf growth suppression by “u” and “me”?
    Shuo Qie, Nianli Sang · 2011 · Cell Cycle
  25. Targeting the Ubiquitin-proteasome System for the Treatment of Multiple Myeloma and Other Human Diseases
    Klaus Podar, Kenneth Carl Anderson · 2010 · Clinical Medicine Insights Therapeutics
  26. Substrate screening identifies a novel target sequence for the proteasomal activity regulated by ionizing radiation
    Angela Broggini‐Tenzer, Andreas Hollenstein, Zbigniew Pianowski, Andrea Wampfler, Polina Furmanova, Nicolas Winssinger, Martin N. Pruschy · 2009 · PROTEOMICS
  27. Movement as Medicine for Cardiovascular Disease Prevention: Pilot Feasibility Study of a Physical Activity Promotion Intervention for At-Risk Patients in Primary Care
    Keegan Phillip Knittle, Sarah J. Charman, Sophie E. O'Connell, Leah Avery, Michael Catt, Falko F. Sniehotta, Michael I. Trenell · 2021 · JMIR Cardio
  28. Regulation and Function of the Original p53- Inducible p21 Gene
    Jennifer A. Fraser · 2010 · Molecular biology intelligence unit
  29. Molecular Targets of Green Tea Catechin, EGCG, on Human Colorectal Carcinogenesis
    Mugdha Sukhthankar · 2009
  30. Role of proteasome-ubiquitination degradation pathway in animal cancer - an insight.
    Supriya Shiwani, Sung‐Jin Lee, Nishant Kumar Singh · 2014 · Research opinions in animal & veterinary sciences
  31. Involvement of The Oncogenic Small Nucleolar RNA SNORA24 In Regulation of P53 Stability In Colorectal Cancer
    Liping Shen, Chuxian Lin, Wenqing Lü, Junyan He, Qi Wang, Yujv Huang, Xiaofei Zheng, Zhidong Wang · 2022 · Research Square
  32. Mechanisms of Ub-independent ODC recognition and translocation by the 26S proteasome revealing proteasome’s functional adaptability
    Kaijian Chen, Yanxing Wang, Xingyan Ye, Zhanyu Ding, Xuyang Yuan, Cong Xu, Yue Yin, Yao Cong · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  33. Avaliação imunológica da vacina proteica E6E7 fusionada a Ubiquitina contra cancer cervical induzido por HPV16.
    Liliane Maria Fernandes de Oliveira · 2012
  34. Hormetic dietary phytochemicals from Western Canadian plants: Identification, characterization and mechanistic insights
    David J. F. Konkin · 2013 · University Library - University of Saskatchewan (University of Saskatchewan)
  35. Modulation of Philadelphia Chromosome-Positive Hematological Malignancies by the Bone Marrow Microenvironment
    Lin Wang, Heather A. O’Leary, Laura F. Gibson · 2009 · Springer eBooks
  36. Modulation of p53 activities by the prolyl-isomerase PIN1 and the bromodomain protein BRD7
    Francesca Tocco · 2008 · OpenstarTs (Univeristy of Trieste https://www.units.it/)
  37. p73 Affects Cell Fate and Tumorigenesis
    Safaa Mahmoud Ramadan, Emre Sayan, Andrew Oberst, Anissa Chikh, Valentina Pietroni, Alessandro Rufini, Gerry Melino, Francesca Bernassola · 2006 · Wiley eBooks
  38. Post-translational Modifications of the p53 Transcription Factor
    Christopher L. Brooks, Wei Jun Gu · 2007 · Springer eBooks
  39. Regulation of polyamine biosynthesis in Saccharomyces cerevisiae
    Rangasamy Palani Murugan · 2005 · Kölner Universitäts PublikationsServer (Universität zu Köln)
  40. Novel mechanisms of quinone toxicity
    Xiong, Rui · 2015
  41. The functions of the RNA polymerase II CTD in transcription and RNA processing
    Jing-Ping Hsin · 2013
  42. Probing Cardiac Calcium Regulation Using Fluorescence Spectroscopy
    Elizabeth L. Lockamy · 2011 · University of Minnesota Digital Conservancy (University of Minnesota)
  43. Role of the 26S Proteasome and Posttranslational Modifications in Regulating the Expression of Retinoic Acid-Responsive Genes
    Aliaa Higazi · 2011 · Library and Archives Canada (Government of Canada)
  44. Heterochromatin effects in Friedreich's ataxia and sexual dimorphism
    Cihangir Yandım · 2012 · Spiral (Imperial College London)
  45. New functions for the major vault protein in the ionizing radiation induced stress response and DNA repair
    Andreas Hollenstein · 2009 · Repository for Publications and Research Data (ETH Zurich)
  46. The Proteasome-associated deubiquitinase UCHL5/UBH-4 in proteasome modulation and as a prognostic marker in gastrointestinal cancers
    Leena Arpalahti · 2018 · Työväentutkimus Vuosikirja
  47. The Tumor Suppressor RASSF1A Links Inflammation and Cancer
    Marilyn Gordon · 2015 · ERA: Education and Research Archive (University of Alberta)
  48. Estudio del papel de p73 en la ciliogénesis y el establecimiento de la polaridad celular planar en células ependimarias = Role of P73 in ependymal cell ciliogenesis and planar cell polarity establishment
    Sandra Fuertes Álvarez · 2017 · Buleria (Universidad de León)
  49. An Outside-In and a Reciprocal Inside-Out Hypothesis Combining Resveratrol and Its High Affinity Protein NQO2 to Target iASPP for Reinstating the Activation and Stabilization of Dysfunctional WTp53 as a Melanoma Chemopreventive Approach
    Tze‐chen Hsieh, Barbara B. Doonan, JOSEPH M. WU · 2018 · Elsevier eBooks
  50. c-Myc Metabolic Addiction in Cancers Counteracted by Resveratrol and NQO2
    Tze‐chen Hsieh, Barbara B. Doonan, JOSEPH M. WU · 2019 · IntechOpen eBooks
  51. Quinone Reductases
    David Ross, David M. Siegel · 2014 · Elsevier eBooks
  52. References
    2009 · Chapman & Hall/CRC eBooks
  53. Faculty Opinions recommendation of Stability and sub-cellular localization of DNA polymerase β is regulated by interactions with NQO1 and XRCC1 in response to oxidative stress.
    Olga I. Lavrik · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  54. Regulation | Quinone Reductase 2: From Classical Role in Detoxification to Emerging Role as a Novel Regulator of Cellular Activities
    JOSEPH M. WU, Tze‐chen Hsieh · 2020 · Elsevier eBooks
  55. The E2F4/p130 repressor complex cooperates with oncogenic ΔNp73α to promote cell survival in human papillomavirus 38 E6/E7-transformed keratinocytes and in cancer cells
    Valério Taverniti, Hanna Krynska, Assunta Venuti, Marie‐Laure Straub, Cécilia Sirand, Eugénie Lohmann, Maria Carmen Romero-Medina, Stefano Moro, Alexis Robitaille, Luc Négroni et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  56. p53 at the Crossroads Between Stress Response Signaling and Tumorigenesis: From Molecular Mechanisms to Therapeutic Opportunities
    Luciana E. Giono, María Fátima Ladelfa, Martín Monte · 2014 · Springer eBooks
  57. Quinone Reductases
    David Ross, David M. Siegel · 2024 · Elsevier eBooks
  58. Active site tyrosine residues in human NQO1 homodimer are critical for non-synchronous enzyme catalysis at the two active sites
    Maribel Rivero, Juan Luis Pacheco‐García, Pavla Vaňková, Dmitry S. Loginov, Isabel Quereda‐Moraleda, Jose Manuel Martin-Garcia, Petr Man, Milagros Medina, Angel Luis Pey · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  59. TBK1-NQO1 negative feedback loop regulates antiviral innate immunity
    Hyuncheol Lee, Asela Weerawardhana, Kiramage Chathuranga, W. A. Gayan Chathuranga, Tae-Hwan Kim, Duk‐Jae Jang, Aleysha Chen, David V. Schaffer, Jae Ung Jung, Chul‐Ho Lee et al. · 2026 · Cell Communication and Signaling
  60. Characterization of protein-protein interactions mediated by the IKK complex
    Stefano Moro · 2022 · theses.fr (ABES)
  61. Tryptophan-Enriched Lactobacillus rhamnosus GG-derived Nanovesicles Promote Alveolar Bone Regeneration through Macrophage Fatty Acid Oxidation
    Zhendong Huang, Yuqi Liu, Qiudong Yang, Jiayi Ding, Zhengkun Yang, Heyu Liu, Xin Huang, Xiaoxuan Wang, Li Ma, Zhengguo Cao · 2026 · Biomaterials Research
  62. Regulation of the 26S Proteasome: From Homeostasis to Stress and Disease
    Victoria Cohen‐Kaplan, Aaron J. Ciechanover, Yelena Kravtsova‐Ivantsiv · 2026 · Cells
  63. Identification of a Ubiquitin-Independent Degron by a Reporter Assay
    Yosef Shaul · 2026 · Methods in molecular biology
  64. Exploring the sex-dependent effects of midnolin loss on hepatic transcription and chromatin accessibility
    Lakshmi Sudeepthi NissankaraRao, Gayeoun Kim, Soo-Mi Kweon, Vaisnavii Mohanraj, Damien Parrello, N. Sreekar, Sheng-Wei Chang, Walter M. K. Tsark, Keane K. Y. Lai, Motoki Takaku · 2026 · Biochemistry and Biophysics Reports
  65. p21 (CDKN1A) Is the Major Driver of Sulforaphane-Mediated Reduction in SAMHD1 T592 Phosphorylation in Macrophages
    Bianka Nicolle Pena Marcelino, Kiersten Girard, Lauren Letourneau, Andrew Lewin, David Lewin, Anna Presicci, Luke Reistrom, Tyler Williams, Hamayun J. Sharifi · 2026 · Biomolecules
  66. Spatiotemporal Redox Regulation of Cell-Cycle Progression: Dynamic Functions of Cellular Redox Regulatory Proteins
    Raghavendra S. Patwardhan, Shruti Morjaria, Gargi Nandi, Syed K. Hasan, Santosh K. Sandur · 2026 · Cells
  67. BindingDB Entry 50031679: Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2.
    BindingDB · 2010 · UC San Diego
  68. BindingDB Entry 50031245: Triazoloacridin-6-ones as novel inhibitors of the quinone oxidoreductases NQO1 and NQO2.
    BindingDB · 2010 · UC San Diego
  69. BindingDB Entry 3486: Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1).
    BindingDB · 2009 · UC San Diego
  70. Role of p53 in Adaptation to the Tumor Microenvironment
    Erin E. Mendoza · 2010 · UA Campus Repository (The University of Arizona)