The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Mouse Sycp1 functions in synaptonemal complex assembly, meiotic recombination, and XY body formation
Open accessAbstract
In meiotic prophase, synaptonemal complexes (SCs) closely appose homologous chromosomes (homologs) along their length. SCs are assembled from two axial elements (AEs), one along each homolog, which are connected by numerous transverse filaments (TFs). We disrupted the mouse gene encoding TF protein Sycp1 to analyze the role of TFs in meiotic chromosome behavior and recombination. Sycp1-/- mice are infertile, but otherwise healthy. Sycp1-/- spermatocytes form normal AEs, which align homologously, but do not synapse. Most Sycp1-/- spermatocytes arrest in pachynema, whereas a small proportion reaches diplonema, or, exceptionally, metaphase I. In leptotene Sycp1-/- spermatocytes, γH2AX (indicative of DNA damage, including double-strand breaks) appears normal. In pachynema, Sycp1-/- spermatocytes display a number of discrete γH2AX domains along each chromosome, whereas γH2AX disappears from autosomes in wild-type spermatocytes. RAD51/DMC1, RPA, and MSH4 foci (which mark early and intermediate steps in pairing/recombination) appear in similar numbers as in wild type, but do not all disappear, and MLH1 and MLH3 foci (which mark late steps in crossing over) are not formed. Crossovers were rare in metaphase I of Sycp1-/- mice. We propose that SYCP1 has a coordinating role, and ensures formation of crossovers. Unexpectedly, Sycp1-/- spermatocytes did not form XY bodies.
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Cites
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Cited by
Sharma, A., Jamil, M. A., Nuesgen, N., Schreiner, F., Priebe, L., Hoffmann, P., Herns, S., Nöthen, M. M., Fröhlich, H., Oldenburg, J., et al. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0112-2 · Cited by 81
Cell cycle and age-related modulations of mouse chromosome stiffness
Liu, N., Qiang, W., Jordan, P. W., Marko, J. F., & Qiao, H. (2025) · eLife · doi:10.7554/elife.97403 · Cited by 3
Cell cycle and age-related modulations of mouse chromosome stiffness
Liu, N., Qiang, W., Jordan, P. W., Marko, J. F., & Qiao, H. (2025) · eLife · doi:10.7554/elife.97403.3 · Cited by 1
Metadata
- Authors
- de Vries, F. A. T., de Boer, E., van den Bosch, M., Baarends, W. M., Ooms, M., Yuan, L., Liu, J.-G., van Zeeland, A. A., Heyting, C., & Pastink, A.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2005-06-01
- Volume
- 19
- Issue
- 11
- Pages
- 1376-1389
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2171960324
- Cited by
- 455
- References
- 45
- Type
- posted content
- Language
- en
- Open access
- diamond
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- de Vries, F. A. T., de Boer, E., van den Bosch, M., Baarends, W. M., Ooms, M., Yuan, L., Liu, J.-G., van Zeeland, A. A., Heyting, C., & Pastink, A. (2005). Mouse Sycp1 functions in synaptonemal complex assembly, meiotic recombination, and XY body formation. Genes & Development. https://doi.org/10.1101/gad.329705
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