The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
RNA Pol II subunit Rpb7 promotes centromeric transcription and RNAi-directed chromatin silencing
Open accessAbstract
Fission yeast centromeric repeats are transcribed into small interfering RNA (siRNA) precursors (pre-siRNAs), which are processed by Dicer to direct heterochromatin formation. Recently, Rpb1 and Rpb2 subunits of RNA polymerase II (RNA Pol II) were shown to mediate RNA interference (RNAi)-directed chromatin modification but did not affect pre-siRNA levels. Here we show that another Pol II subunit, Rpb7 has a specific role in pre-siRNA transcription. We define a centromeric pre-siRNA promoter from which initiation is exquisitely sensitive to the rpb7-G150D mutation. In contrast to other Pol II subunits, Rpb7 promotes pre-siRNA transcription required for RNAi-directed chromatin silencing.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
Cited by
Grewal, S. I. S., & Jia, S. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2008 · Cited by 1,263
H3K9me3-Dependent Heterochromatin: Barrier to Cell Fate Changes
Becker, J. S., Nicetto, D., & Zaret, K. S. (2016) · Trends in Genetics · doi:10.1016/j.tig.2015.11.001 · Cited by 485
Role of H3K9me3 heterochromatin in cell identity establishment and maintenance
Nicetto, D., & Zaret, K. S. (2019) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2019.04.013 · Cited by 312
Heterochromatin formation in the mouse embryo requires critical residues of the histone variant H3.3
Santenard, A., Ziegler-Birling, C., Koch, M., Tora, L., Bannister, A. J., & Torres-Padilla, M.-E. (2010) · Nature Cell Biology · doi:10.1038/ncb2089 · Cited by 300
Common themes in siRNA-mediated epigenetic silencing pathways
Verdel, A., Vavasseur, A., Le Gorrec, M., & Touat-Todeschini, L. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082691av · Cited by 135
Metadata
- Authors
- Djupedal, I., Portoso, M., Spåhr, H., Bonilla, C., Gustafsson, C. M., Allshire, R. C., & Ekwall, K.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2005-10-01
- Volume
- 19
- Issue
- 19
- Pages
- 2301-2306
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2169577566
- Cited by
- 220
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: RNA Pol II subunit Rpb7 promotes centromeric transcription and RNAi-directed chromatin silencing. https://app.cochat.ai/papers/10.1101/gad.344205
- The paper
- Djupedal, I., Portoso, M., Spåhr, H., Bonilla, C., Gustafsson, C. M., Allshire, R. C., & Ekwall, K. (2005). RNA Pol II subunit Rpb7 promotes centromeric transcription and RNAi-directed chromatin silencing. Genes & Development. https://doi.org/10.1101/gad.344205
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
