The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The basic region of AP-1 specifies glucocorticoid receptor activity at a composite response element.
Open accessAbstract
Unrelated factors collaborate at composite response elements to confer novel patterns of transcriptional regulation. For example, AP-1 and glucocorticoid receptor bind and mutually affect their activities at a 25-bp composite element, plfG. We found that different members of the AP-1 factor family that behave similarly in the absence of receptor are strikingly distinct in its presence: They specify opposite (enhancement vs. repression) regulatory actions by the receptor. Four amino acids within the AP-1 DNA-binding domain were identified as crucial determinants of receptor regulatory activity at plfG. We conclude that interactions of factors from separate transcription factor families at composite response elements provide a mechanism by which a single factor can regulate both positively or negatively, and a potential resolution of the apparent functional redundancy within regulatory factor families.
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Cites
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Self-citationMechanism of specificity in the Fos-Jun oncoprotein heterodimer
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Cited by
De Bosscher, K., Vanden Berghe, W., & Haegeman, G. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0006 · Cited by 898
The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun
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Glucocorticoid receptor control of transcription: precision and plasticity via allostery
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Metadata
- Authors
- Miner, J. N., & Yamamoto, K. R.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1992-12-01
- Volume
- 6
- Issue
- 12b
- Pages
- 2491-2501
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2050246426
- Cited by
- 158
- References
- 6
- Type
- posted content
- Language
- en
- Open access
- diamond
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