The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Identification of a growth suppression domain within the retinoblastoma gene product.
Open accessAbstract
To date, all naturally occurring retinoblastoma susceptibility gene (RB) mutations known to be compatible with stable protein expression map to the T/E1A and cellular protein-binding region (the "pocket" domain). This domain extends from residue 379 to 792. When full-length RB and certain truncated forms were synthesized in human RB -/- cells, we found that the minimal region necessary for overt growth suppression extended from residue 379 to 928. A functional pocket domain and sequences extending from the carboxy-terminal boundary of the pocket to the carboxyl terminus of the protein were both necessary for growth suppression. Both sets of sequences were also required for E2F binding; hence, the two functions may be linked.
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Cites
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
Friend, S. H., Bernards, R., Rogelj, S., Weinberg, R. A., Rapaport, J. M., Albert, D. M., & Dryja, T. P. (1986) · Nature · doi:10.1038/323643a0 · Cited by 2,948
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Self-citationCell cycle dependent regulation of phosphorylation of the human retinoblastoma gene product
Mihara, K., Cao, X.-R., Yen, A., Chandler, S., Driscoll, B., Murphree, A. L., T'Ang, A., & Fung, Y.-K. (1989) · Science · doi:10.1126/science.2588006 · Cited by 449
Cited by
Effects of an Rb mutation in the mouse
Jacks, T., Fazeli, A., Schmitt, E. M., Bronson, R. T., Goodell, M. A., & Weinberg, R. A. (1992) · Nature · doi:10.1038/359295a0 · Cited by 1,755
E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins
Nevins, J. R. (1992) · Science · doi:10.1126/science.1411535 · Cited by 1,506
New functional activities for the p21 family of CDK inhibitors.
LaBaer, J., Garrett, M. D., Stevenson, L. F., Slingerland, J. M., Sandhu, C., Chou, H. S., Fattaey, A., & Harlow, E. (1997) · Genes & Development · doi:10.1101/gad.11.7.847 · Cited by 1,402
Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma
Johnson, B. E., Mazor, T., Hong, C., Barnes, M., Aihara, K., McLean, C. Y., Fouse, S. D., Yamamoto, S., Ueda, H., Tatsuno, K., et al. (2014) · Science · doi:10.1126/science.1239947 · Cited by 1,362
(1993) · Genes & Development · doi:10.1101/gad.7.3.331 · Cited by 1,264
Metadata
- Authors
- Qin, X. Q., Chittenden, T., Livingston, D. M., & Kaelin, W. G.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1992-06
- Volume
- 6
- Issue
- 6
- Pages
- 953-964
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W1994840092
- Cited by
- 404
- References
- 4
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Qin, X. Q., Chittenden, T., Livingston, D. M., & Kaelin, W. G. (1992). Identification of a growth suppression domain within the retinoblastoma gene product. Genes & Development. https://doi.org/10.1101/gad.6.6.953
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