Synergism in transcriptional activation: a kinetic view.
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Single-molecule footprinting methods that use methyltransferases to mark accessible sites can provide quantitative measurements of binding states across individual molecules.
“single-molecule footprinting methods that use methyltransferases to mark accessible sites11–15 can provide quantitative measurements of these binding states across individual molecules”
From Single-molecule states link transcription factor binding to gene expression (2024) · cites this paper as [12]
The “Branches in the pathway for transcriptional initiation” section mentions footprinting experiments showing that most DNA templates were bound within complexes. It does not describe methyltransferase-based single-molecule footprinting or quantitative measurement of binding states across individual molecules. Searches for those methods and measurements found no supporting passage in our copy; page numbers were unavailable. (LLM, conf=0.76)
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- Fersht, A.M. 1985. Enzyme structure and mechanism, 2nd ed., pp. 117-120.
- Giniger, E. and M. Ptashne. 1988. Cooperative DNA binding of the yeast transcriptional activator GAL4. Proc. Natl. Acad. Sci. 85: 382-386.
- Hopfield, l.J. 1974. Kinetic proofreading: A new mechanism for reducing errors in biosynthetic processes requiring high specificity. Proc. Natl. Acad. Sci. 71: 4135-4139.
- Janson, L. and U. Pettersson. 1990. Cooperative interactions between transcription factors Spl and OTF-1. Proc. Natl. Acad. Sci. 87: 4732-4736.
- Laidler, K.J. 1978. Physical Chemistry with Biological Applica- tions, pp. 391-398.
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- Authors
- Herschlag, D., & Johnson, F. B.
- Affiliations
- Stanford University (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1993-02
- Volume
- 7
- Issue
- 2
- Pages
- 173-179
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2054435912
- Cited by
- 190
- References
- 0
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 3 · 2013: 2 · 2012: 2
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Strong
- National Institute of General Medical Sciences (2T32GM07365, T32GM007365)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- transcriptional activation, synergistic effect, transcriptional regulation, reaction kinetics, gene expression regulation
- MeSH terms
- Kinetics, Models, Biological, Trans-Activators
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