The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm.
Open accessAbstract
The HIV-1 Rev protein is a nuclear trans-activator essential for the transport of unspliced viral transcripts to the cytoplasm. In this paper we demonstrate that Rev, rather than being confined to the nucleus, is constantly shuttling between the nucleus and the cytoplasm. We also show that inactivation of Rev's leucine-rich activation domain generates mutant proteins that not only fail to induce the nuclear export of viral transcripts but are also unable to enter the cytoplasm. On the basis of this correlation, we propose that Rev activates viral mRNA transport by directly binding to these RNAs and translocating, with them, to the cytoplasm. In addition, these results also identify, for the first time, a peptide sequence that is important for nuclear export.
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Citations
Cites
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Self-citationMajor nucleolar proteins shuttle between nucleus and cytoplasm
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Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm
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[71] Use of eukaryotic expression technology in the functional analysis of cloned genes
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Self-citationNucleic acid structure and expression of the human AIDS/lymphadenopathy retrovirus
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A second post-transcriptional trans-activator gene required for HTLV-III replication
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Cited by
Wolff, B., Sanglier, J.-J., & Wang, Y. (1997) · Chemistry & Biology · doi:10.1016/s1074-5521(97)90257-x · Cited by 657
Fouchier, R. A. M. (1997) · The EMBO Journal · doi:10.1093/emboj/16.15.4531 · Cited by 339
Sandri-Goldin, R. M. (1998) · Genes & Development · doi:10.1101/gad.12.6.868 · Cited by 264
Pasquinelli, A. E., Ernst, R. K., Lund, E., Grimm, C., Zapp, M. L., Rekosh, D., Hammarskjöld, M., & Dahlberg, J. E. (1997) · The EMBO Journal · doi:10.1093/emboj/16.24.7500 · Cited by 239
The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP
Askjaer, P., Jensen, T. H., Nilsson, J., Englmeier, L., & Kjems, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.50.33414 · Cited by 219
Metadata
- Authors
- Meyer, B. E., & Malim, M. H.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1994-07-01
- Volume
- 8
- Issue
- 13
- Pages
- 1538-1547
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2090038275
- Cited by
- 305
- References
- 78
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Meyer, B. E., & Malim, M. H. (1994). The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm. Genes & Development. https://doi.org/10.1101/gad.8.13.1538
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
