The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
Open accessAbstract
The adaptation of growth in response to nutritional changes is essential for the proper development of all organisms. Here we describe the identification of the Drosophila homolog of the target of rapamycin (TOR), a candidate effector for nutritional sensing. Genetic and biochemical analyses indicate that dTOR impinges on the insulin signaling pathway by autonomously affecting growth through modulating the activity of dS6K. However, in contrast to other components in the insulin signaling pathway, partial loss of dTOR function preferentially reduces growth of the endoreplicating tissues. These results are consistent with dTOR residing on a parallel amino acid sensing pathway.
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Citations
Cites
Coordination of growth with cell division in the yeast
JOHNSTON, G., PRINGLE, J., & HARTWELL, L. (1977) · Experimental Cell Research · doi:10.1016/0014-4827(77)90154-9 · Cited by 827
Cited by
TOR signaling in growth and metabolism
Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787
Upstream and downstream of mTOR
Hay, N., & Sonenberg, N. (2004) · Genes & Development · doi:10.1101/gad.1212704 · Cited by 4,181
Regulation of translation initiation by FRAP/mTOR
Gingras, A.-C., Raught, B., & Sonenberg, N. (2001) · Genes & Development · doi:10.1101/gad.887201 · Cited by 1,545
Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks
Alers, S., Löffler, A. S., Wesselborg, S., & Stork, B. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06159-11 · Cited by 1,483
Regulation of TORC1 by Rag GTPases in nutrient response
Kim, E., Goraksha-Hicks, P., Li, L., Neufeld, T. P., & Guan, K.-L. (2008) · Nature Cell Biology · doi:10.1038/ncb1753 · Cited by 1,349
Metadata
- Authors
- Oldham, S., Montagne, J., Radimerski, T., Thomas, G., & Hafen, E.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-11-01
- Volume
- 14
- Issue
- 21
- Pages
- 2689-2694
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2055248589
- Cited by
- 429
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Oldham, S., Montagne, J., Radimerski, T., Thomas, G., & Hafen, E. (2000). Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes & Development. https://doi.org/10.1101/gad.845700
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