The POU domain: versatility in transcriptional regulation by a flexible two-in-one DNA-binding domain.
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The POU domain linker flexibly connects the POU homeo- and POU-specific domains and appears unstructured in the Oct-1-DNA co-crystal structure.
“This linker was chosen because it flexibly connects the POU homeo-and POUspecific domains (Herr and Cleary, 1995), and appears unstructured in the Oct-1-DNA co-crystal structure (Klemm et al., 1994).”
From Assembly requirements of PU.1–Pip (IRF‐4) activator complexes: inhibiting function in vivo using fused dimers (1999) · cites this paper as Herr and Cleary, 1995
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References 120 · Cited by 388
- Authors
- Herr, W., & Cleary, M. A.
- Affiliations
- State University of New York (US)
- ORCID
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1995-07-15
- Volume
- 9
- Issue
- 14
- Pages
- 1679-1693
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2153017169
- Cited by
- 388
- References
- 120
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 10 · 2019: 5 · 2018: 7 · 2017: 7 · 2016: 3 · 2015: 4 · 2014: 11 · 2013: 7 · 2012: 13
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Keywords
- POU domain, transcriptional regulation, DNA-binding domain, transcription factors
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Binding Sites, DNA, DNA-Binding Proteins, Models, Molecular, Molecular Sequence Data, Mutation, Transcription Factors, Molecular Structure, Transcriptional Activation, Herpes Simplex Virus Protein Vmw65, Helix-Loop-Helix Motifs, Homeodomain Proteins, POU Domain Factors, Octamer Transcription Factor-1, Host Cell Factor C1
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