The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
kuzbanian-mediated cleavage of Drosophila Notch
Open accessAbstract
Loss of Kuzbanian, a member of the ADAM family of metalloproteases, produces neurogenic phenotypes in Drosophila. It has been suggested that this results from a requirement for kuzbanian-mediated cleavage of the Notch ligand Delta. Using transgenic Drosophila expressing transmembrane Notch proteins, we show that kuzbanian, independent of any role in Delta processing, is required for the cleavage of Notch. We show that Kuzbanian can physically associate with Notch and that removal of kuzbanian activity by RNA-mediated interference in Drosophila tissue culture cells eliminates processing of ligand-independent transmembrane Notch molecules. Our data suggest that in Drosophila, kuzbanian can mediate S2 cleavage of Notch.
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Clemens, J. C., Worby, C. A., Simonson-Leff, N., Muda, M., Maehama, T., Hemmings, B. A., & Dixon, J. E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.110149597 · Cited by 843
Cited by
The Disintegrin/Metalloproteinase ADAM10 Is Essential for the Establishment of the Brain Cortex
Jorissen, E., Prox, J., Bernreuther, C., Weber, S., Schwanbeck, R., Serneels, L., Snellinx, A., Craessaerts, K., Thathiah, A., Tesseur, I., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5221-09.2010 · Cited by 363
LaVoie, M. J., & Selkoe, D. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302659200 · Cited by 355
Rumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling
Acar, M., Jafar-Nejad, H., Takeuchi, H., Rajan, A., Ibrani, D., Rana, N. A., Pan, H., Haltiwanger, R. S., & Bellen, H. J. (2008) · Cell · doi:10.1016/j.cell.2007.12.016 · Cited by 306
RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity
Muraguchi, T., Takegami, Y., Ohtsuka, T., Kitajima, S., Chandana, E. P. S., Omura, A., Miki, T., Takahashi, R., Matsumoto, N., Ludwig, A., et al. (2007) · Nature Neuroscience · doi:10.1038/nn1922 · Cited by 149
The ADAMs family: Coordinators of nervous system development, plasticity and repair
Yang, P., Baker, K. A., & Hagg, T. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.05.001 · Cited by 116
Metadata
- Authors
- Lieber, T., Kidd, S., & Young, M. W.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2002-01-15
- Volume
- 16
- Issue
- 2
- Pages
- 209-221
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2166225419
- Cited by
- 232
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Lieber, T., Kidd, S., & Young, M. W. (2002). kuzbanian-mediated cleavage of Drosophila Notch. Genes & Development. https://doi.org/10.1101/gad.942302
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