Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons
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Formation of highly organized neocortical structure depends on the production and correct placement of the appropriate number and types of neurons. POU homeodomain proteins Brn-1 and Brn-2 are coexpressed in the developing neocortex, both in the late precursor cells and in the migrating neurons. Here we show that double disruption of both Brn-1 and Brn-2 genes in mice leads to abnormal formation of the neocortex with dramatically reduced production of layer IV–II neurons and defective migration of neurons unable to express mDab1 . These data indicate that Brn-1 and Brn-2 share roles in the production and positioning of neocortical neuron development.
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Analysis of Brn1/Brn2 double mutant mice demonstrated that these genes regulate neurogenesis and proliferation in the cerebral cortex of glutamatergic precursor fields.
“analysis of Brn1/Brn2 double mutant mice31, 38 demonstrated that these genes regulate neurogenesis and proliferation in the cerebral cortex of glutamatergic precursor fields.”
From Altered proliferation and networks in neural cells derived from idiopathic autistic individuals (2017) · cites this paper as [38]
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References 29 · Cited by 259
- Authors
- Sugitani, Y., Nakai, S., Minowa, O., Nishi, M., Jishage, K.-I., Kawano, H., Mori, K., Ogawa, M., & Noda, T.
- Affiliations
- Japanese Foundation For Cancer Research (JP)
- Tohoku University (JP)
- Corresponding author
- Noda, Tetsuo
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2002-07-15
- Volume
- 16
- Issue
- 14
- Pages
- 1760-1765
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC186401
- OpenAlex
- W2153167703
- Cited by
- 259
- References
- 29
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 4 · 2023: 6 · 2022: 13 · 2021: 15 · 2020: 8 · 2019: 11 · 2018: 12 · 2017: 11 · 2016: 12 · 2015: 15 · 2014: 7 · 2013: 19 · 2012: 12
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- Brn2, neocortex development, neuronal migration, Dab1, double knockout mice, cortical lamination
- MeSH terms
- Animals, Cell Differentiation, Embryonic and Fetal Development, Nerve Tissue Proteins, Neurons, Neuropeptides, Transcription Factors, Biomarkers, Trans-Activators, Gene Expression, Mice, Knockout, Homeodomain Proteins, Cell Lineage, Neocortex, POU Domain Factors, Mice
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