Analysis of alternative splicing associated with aging and neurodegeneration in the human brain

Cited by (254)

Items 201–254 of 254

  1. Identification of pararosaniline as a modifier of RNA splicing in Caenorhabditis elegans
    Dylan Huynh, Cheng‐Wei Wu · 2023 · G3 Genes Genomes Genetics
  2. Molecular Regulation of Fetal Brain Development in Inbred and Congenic Mouse Strains Differing in Longevity
    Maliha Islam, Susanta K. Behura · 2024 · Genes
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    Patricia Sieber, Emanuel Barth, Manja Marz · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  4. Methylome analysis of FTLD patients with TDP-43 pathology identifies epigenetic signatures specific to pathological subtypes
    Cristina T. Vicente, Tejasvi Niranjan, Elise Coopman, Júlia Faura, Sara Alidadiani, Claudia Schrauwen, Billie J. Matchett, Bavo Heeman, Marleen Van den Broeck, Wouter De Coster et al. · 2025 · Molecular Neurodegeneration
  5. Inhibiting Glycogen Synthase Kinase 3 Suppresses TDP-43-Mediated Neurotoxicity in a Caspase-Dependent Manner
    Matthew A. White, Leon Crowley, Francesca Massenzio, Xingli Li, Michael Niblock, Sara Milani, Michael P. Coleman, Sami J. Barmada, Jemeen Sreedharan · 2026 · Molecular Neurobiology
  6. Ribosome impairment, tau alternative splicing, and stress granules: a convergent axis of neuronal vulnerability driving Alzheimer's disease
    Mirco Masi, Chiara Oliviero, Stefano M. Govoni, Benjamin L. Wolozin, Marco Racchi, Erica Buoso · 2026 · European Journal of Pharmacology
  7. TDP-43 is essential for Eph receptor-class-specific spinal motor axon trajectory into the limb
    Tzu‐Jen Kao, Chih‐Yang Wang, Tsung‐I Hsu, Yi‐Hsin Wu, Jiang-Ying Chuang, Chi-Chen Sarah Huang, Cheng Ta Hsieh · 2021 · Neuroscience Research
  8. Post-transcriptional regulation
    Ayeman Amanullah · 2022 · Elsevier eBooks
  9. [Tau Protein Induces Aberrant Alternative Splicing Changes in PS19 Transgenic Mice].
    Xuewen Tian, Chan Chen, Xiong Wang · 2023 · PubMed Central
  10. Computational approaches for the systematic analysis of aging-associated molecular alterations
    Cédric Debès, Ana Carolina Leote, Andreas Beyer · 2018 · Drug Discovery Today Disease Models
  11. Basic pathways and targets for anti-aging intervention
    Mercedes Cano, Yiu To Yeung, Mario F. Muñoz, Antonio Ayala, Angélica Guerrero‐Castilla, Sandro Argüelles · 2023 · Elsevier eBooks
  12. The genomic underpinnings of oscillatory biomarkers supporting successful memory encoding in humans
    Stefano Berto, Miles R. Fontenot, Sarah E. Seger, Fatma Ayhan, Emre Caglayan, Ashwinikumar Kulkarni, Connor Douglas, Carol A. Tamminga, Bradley Charles Lega, Geneviève Konopka · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  13. Inhibiting glycogen synthase kinase 3 suppresses TDP-43-mediated neurotoxicity in a caspase-dependant manner
    Matthew A. White, Francesca Massenzio, Xingli Li, Michael P. Coleman, Sami J. Barmada, Jemeen Sreedharan · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  14. Heterogeneity of novel APOER2 isoforms specific to Alzheimer’s disease impact cellular and synaptic states
    Christina M. Gallo, Sabrina A. Kistler, Anna Natrakul, Adam Thomas Labadorf, Uwe Beffert, Angela Ho · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  15. Dysregulation of alternative splicing patterns in the ovaries of reproductively aged mice
    Nehemiah S. Alvarez, Pavla Brachova · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  16. Age-related microbiome metabolites alter RNA splicing and chromatin accessibility in the brain
    Meenakshi Chakraborty, Sophia M. Shi, Imani E. Porter, Daniel J. Richard, Georgi K. Marinov, Mukundh N. Murthy, Ashley A. Moore, Jenna Lynn Elizabeth Blum, Aravind Natarajan, James W.S. Jahng et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  17. Exploring the transcriptome of the brain
    Allissa Dillman · 2014 · Figshare
  18. Splicing-Sensitive DNA-Microarrays: Peculiarities and Application in Biomedical Research (Review)
    D. I. Knyazev, В. Д. Старикова, Oleg Vladimirovich Utkin, Leonid A. Solntsev, Сахарнов Николай Александрович, Е.И. Ефимов · 2015 · Современные технологии в медицине
  19. The role of Kat2a during memory formation and chromatin plasticity in the aging murine hippocampus
    Roman Manuel Stilling · 2013 · eDiss (Georg-August-Universität Göttingen)
  20. Review Article Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer's disease, Parkinson's disease, and related disorders
    Vijay K. Ramanan, Andrew J. Saykin · 2013
  21. The effects of metabolic conditions relevant to Type 2 Diabetes on alternative splicing
    Mahfuja Jannat Bulu · 2018 · Research Repository (Kingston University London)
  22. Simultaneous transcriptome and methylome profiles of single mouse oocytes provide novel insights on maturation and aging
    Qian Yan, Qin Cao, Jinyue Liao, Chun Shui Luk, Ashley Hoi Ching Suen, Annie Wing-Tung Lee, Ting Hei Thomas Chan, Judy Kin Wing Ng, Nelson L.S. Tang, Hoi Sze Chung et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  23. RNA and aging
    Milan Mušo · 2020 · Elsevier eBooks
  24. Translational suppression via IFG-1/eIF4G confers resistance to stress-induced RNA alternative splicing in Caenorhabditis elegans
    Samantha C. Chomyshen, Cheng‐Wei Wu · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  25. Functional genomics
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  26. The CircRNAs for Diagnostic, Prognostic, and Therapy in Alzheimer’s Disease
    Erika Alejandra Cabrera-Reyes, Miguel Alejandro Jiménez-Acosta, Mayte Lizeth Padilla-Cristerna, Marco Antonio Meraz‐Ríos · 2022 · Advances in Bioscience and Biotechnology
  27. Mechanism and treatment of cell death in Alzheimer's disease
    Zhixuan Zhu · 2023 · Highlights in Science Engineering and Technology
  28. Long-read transcriptomic identification of synaptic adaptation to amyloid pathology in the App NL-G-F knock-in mouse model of the earliest phase of Alzheimer’s disease
    Ümran Yaman, Gareth T. Banks, Emil Karl Gustavsson, Paige Mumford, Naciye Magusali, Orjona Stella Taso, Hannah L. Macpherson, Susana Carmona, Malgorzata Murray, Rasneer Sonia Bains et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  29. Resolving chromatin interaction and transcriptional networks in mammalian nuclei
    Yajie Zhu · 2024 · eDiss (Georg-August-Universität Göttingen)
  30. Long-read transcriptomics in neurodegeneration
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  31. Structural and functional insights into nuclear role of Parkinson’s Disease-associated α-Synuclein
    Sneha Jos, Archanalakshmi Kambaru, T.K. Prasad, Shylaja Parthasarathi, Neelagandan Kamariah, Sangeeta Nath, Balasundaram Padmanabhan, Sivaraman Padavattan · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  32. Short- and Long-Non-coding RNA Causes Global Alterations in the Genome and Proteome in Cancer and Other Disorders
    Jyotsna Singh, Aastha Pandey, Sharad Awasthi, Sarat Kumar Kottarath, Mohd Farhan, Yogesh Srivastava · 2025 · Springer eBooks
  33. Alternative splicing and the aging brain in AfrAbia: New frontiers in dementia research
    Suliyat Abiodun Aremu · 2025 · IBRO Neuroscience Reports
  34. Proteo-transcriptomic reprogramming and resource reallocation define the aging mammalian brain
    Nisha Hemandhar Kumar, Verena Kluever, Svenja V. Kaufmann, Cornelius Bergmann, Kanaan Mousaei, Miguel Tomas, Miguel Correa Marrero, Avika Chopra, Misa Hirose, Mercè Pallàs et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  35. Tau protein isoforms in neuropathological aging: Gerosuppressors, gerogenes or just travel companions
    Jesús Ávila, Félix Hernández, José Viña · 2025 · Geromedicine
  36. Identification of small ubiquitin-related modifier (SUMO)-related genes-based biomarkers in Alzheimer’s disease based on bioinformatics analysis
    Peng Chen, Mengting Fan, Hailiang Lin, Zhong Chen, Qiuyang Zhang, Yunfan Cheng, Jing Xu · 2026 · Scientific Reports
  37. Estudi bioinformàtic de la funcionalitat i conservació de l’splicing alternatiu
    Jordi Morata · 2012 · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
  38. Additional file 1 of Clusters of co-abundant proteins in the brain cortex associated with fronto-temporal lobar degeneration
    Claire Bridel, Juami H. M. van Gils, Suzanne S. M. Miedema, Jeroen J.M. Hoozemans, Yolande A.L. Pijnenburg, August B. SMIT, Annemieke J.M. Rozemüller, Sanne Abeln, Charlotte Elisabeth Teunissen · 2024 · Figshare
  39. Additional file 1 of Functional enrichment of alternative splicing events with NEASE reveals insights into tissue identity and diseases
    Zakaria Louadi, Elkjaer, Maria L., Klug, Melissa, Chit Tong Lio, Amit M. Fenn, Zsolt Illés, Dario Bongiovanni, Baumbach, Jan, Tim Kacprowski, List, Markus et al. · 2021 · Figshare
  40. Additional file 8 of Functional enrichment of alternative splicing events with NEASE reveals insights into tissue identity and diseases
    Zakaria Louadi, Maria L. Elkjaer, Klug, Melissa, Chit Tong Lio, Amit M. Fenn, Zsolt Illés, Dario Bongiovanni, Baumbach, Jan, Tim Kacprowski, List, Markus et al. · 2021 · Figshare
  41. A combination of differential expression and network connectivity analyses identifies a common set of RNA splicing and processing genes altered with age across human tissues
    Caio M.P.F. Batalha, André Fujita, Nadja Cristhina de Souza-Pinto · 2025 · Aging
  42. Exploring Splicing‐Energy Axis Associations to Diet and Longevity
    Stefano Donegà, Myriam Gorospe, Luigi Ferrucci · 2025 · Aging Cell
  43. Post-transcriptional regulation in intervertebral disc degeneration
    Xinyu Li, Huaizhen Liang, Zhi Du, Rui Shi, Yu Song, Cao Yang · 2026 · Genes & Diseases
  44. Brain aging mediates region-specific transcriptomic alterations
    Adel B Alharbi · 2026 · Biosystems
  45. Rôle cellulaire et développemental du transporteur lysosomal PQLC2 dans un modèle murin
    Solène Lebrun · 2023 · theses.fr (ABES)
  46. mRNA enhanced cell therapy and reverse aging
    Vibha Dwivedi, Mukulika Ray, Anand Kumar Singh · 2026 · Elsevier eBooks
  47. Locus-specific LINE-1 mRNA expression reflects cell-type- and stimulus-specific senescence states
    Minh N. Tran, Sihan Liu, Melody Baddoo, Emily C. Stow, Sudesh K Srivastav, Victoria P. Belancio · 2026 · Nucleic Acids Research
  48. HnRNPAB -targeted antisense oligonucleotides ameliorate tau pathology and cognitive deficits by modulating Alzheimer’s disease-associated alternative splicing
    Tao Jiang, Xingjun Xu, Yaqiong Yu, Caixin Zhu, Chao Ma, Yu Tang, Lingxia Min, Mingliang Tan, Jialin Bai, Zhou Feng et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  49. Normal spermatogenesis in older men is associated with compensatory transcriptome changes
    Yihan Wang, Sven Berres, Henrike Krenz, Tobias Tekath, Marius Wöste, Sarah Sandmann, Amelie Körtje, Anna Henrich, Nicole Terwort, Frank Tüttelmann et al. · 2026 · GeroScience
  50. Compartment-specific inhibition of cytosolic Cathepsin B mitigates microglial senescence in the aging brain
    Simeng Zhang, Chen Zhang, Jian Mao, Junjun Ni · 2026 · Pharmacological Research
  51. Caloric restriction drives age-dependent and integrated remodeling of RNA processing and lipid composition in mouse brain
    Spencer Tye, Josef P. Clark, Andrew Engeler, Anshit Singh, Rozalyn M. Anderson, Timothy W. Rhoads · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  52. Transitional Neuronal States Suggest Divergent Trajectories of Resilience and Neurodegeneration in an Alzheimer’s Disease Mouse Model
    Yun‐Juan Chang, Philip H. Stavrides, Harshitha Pidikiti, Kyrillos W. Ibrahim, Ju‐Hyun Lee, Martin J. Berg, Kuldeep Singh Sachdeva, Stephen D. Ginsberg · 2026 · Brain Sciences
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    BindingDB · 2013 · UC San Diego
  54. BindingDB Entry 50044700: Hydroxybenzothiophene Ketones Are Efficient Pre-mRNA Splicing Modulators Due to Dual Inhibition of Dyrk1A and Clk1/4.
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