Analysis of alternative splicing associated with aging and neurodegeneration in the human brain
Tollervey, James R., Wang, Zhen, Hortobágyi, Tibor, Witten, Joshua T., Zarnack, Kathi, Kayikci, Melis, Clark, Tyson A., Schweitzer, Anthony C., Rot, Gregor, Curk, Tomaž, Zupan, Blaž, Rogelj, Boris, Shaw, Christopher E., Ule, Jernej·2011·Genome Research
Cited by (254)
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- TDP-43 is essential for Eph receptor-class-specific spinal motor axon trajectory into the limbTzu‐Jen Kao, Chih‐Yang Wang, Tsung‐I Hsu, Yi‐Hsin Wu, Jiang-Ying Chuang, Chi-Chen Sarah Huang, Cheng Ta Hsieh · 2021 · Neuroscience Research
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- [Tau Protein Induces Aberrant Alternative Splicing Changes in PS19 Transgenic Mice].Xuewen Tian, Chan Chen, Xiong Wang · 2023 · PubMed Central
- Computational approaches for the systematic analysis of aging-associated molecular alterationsCédric Debès, Ana Carolina Leote, Andreas Beyer · 2018 · Drug Discovery Today Disease Models
- Basic pathways and targets for anti-aging interventionMercedes Cano, Yiu To Yeung, Mario F. Muñoz, Antonio Ayala, Angélica Guerrero‐Castilla, Sandro Argüelles · 2023 · Elsevier eBooks
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- Inhibiting glycogen synthase kinase 3 suppresses TDP-43-mediated neurotoxicity in a caspase-dependant mannerMatthew A. White, Francesca Massenzio, Xingli Li, Michael P. Coleman, Sami J. Barmada, Jemeen Sreedharan · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Heterogeneity of novel APOER2 isoforms specific to Alzheimer’s disease impact cellular and synaptic statesChristina M. Gallo, Sabrina A. Kistler, Anna Natrakul, Adam Thomas Labadorf, Uwe Beffert, Angela Ho · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Dysregulation of alternative splicing patterns in the ovaries of reproductively aged miceNehemiah S. Alvarez, Pavla Brachova · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Age-related microbiome metabolites alter RNA splicing and chromatin accessibility in the brainMeenakshi Chakraborty, Sophia M. Shi, Imani E. Porter, Daniel J. Richard, Georgi K. Marinov, Mukundh N. Murthy, Ashley A. Moore, Jenna Lynn Elizabeth Blum, Aravind Natarajan, James W.S. Jahng et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Exploring the transcriptome of the brainAllissa Dillman · 2014 · Figshare
- Splicing-Sensitive DNA-Microarrays: Peculiarities and Application in Biomedical Research (Review)D. I. Knyazev, В. Д. Старикова, Oleg Vladimirovich Utkin, Leonid A. Solntsev, Сахарнов Николай Александрович, Е.И. Ефимов · 2015 · Современные технологии в медицине
- The role of Kat2a during memory formation and chromatin plasticity in the aging murine hippocampusRoman Manuel Stilling · 2013 · eDiss (Georg-August-Universität Göttingen)
- Review Article Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer's disease, Parkinson's disease, and related disordersVijay K. Ramanan, Andrew J. Saykin · 2013
- The effects of metabolic conditions relevant to Type 2 Diabetes on alternative splicingMahfuja Jannat Bulu · 2018 · Research Repository (Kingston University London)
- Simultaneous transcriptome and methylome profiles of single mouse oocytes provide novel insights on maturation and agingQian Yan, Qin Cao, Jinyue Liao, Chun Shui Luk, Ashley Hoi Ching Suen, Annie Wing-Tung Lee, Ting Hei Thomas Chan, Judy Kin Wing Ng, Nelson L.S. Tang, Hoi Sze Chung et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- RNA and agingMilan Mušo · 2020 · Elsevier eBooks
- Translational suppression via IFG-1/eIF4G confers resistance to stress-induced RNA alternative splicing in Caenorhabditis elegansSamantha C. Chomyshen, Cheng‐Wei Wu · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Functional genomicsCaleb Webber · 2020 · New Oxford Textbook of Psychiatry
- The CircRNAs for Diagnostic, Prognostic, and Therapy in Alzheimer’s DiseaseErika Alejandra Cabrera-Reyes, Miguel Alejandro Jiménez-Acosta, Mayte Lizeth Padilla-Cristerna, Marco Antonio Meraz‐Ríos · 2022 · Advances in Bioscience and Biotechnology
- Mechanism and treatment of cell death in Alzheimer's diseaseZhixuan Zhu · 2023 · Highlights in Science Engineering and Technology
- Long-read transcriptomic identification of synaptic adaptation to amyloid pathology in the App NL-G-F knock-in mouse model of the earliest phase of Alzheimer’s diseaseÜmran Yaman, Gareth T. Banks, Emil Karl Gustavsson, Paige Mumford, Naciye Magusali, Orjona Stella Taso, Hannah L. Macpherson, Susana Carmona, Malgorzata Murray, Rasneer Sonia Bains et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Resolving chromatin interaction and transcriptional networks in mammalian nucleiYajie Zhu · 2024 · eDiss (Georg-August-Universität Göttingen)
- Long-read transcriptomics in neurodegenerationEmil Karl Gustavsson, Hannah L. Macpherson · 2024 · Elsevier eBooks
- Structural and functional insights into nuclear role of Parkinson’s Disease-associated α-SynucleinSneha Jos, Archanalakshmi Kambaru, T.K. Prasad, Shylaja Parthasarathi, Neelagandan Kamariah, Sangeeta Nath, Balasundaram Padmanabhan, Sivaraman Padavattan · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Short- and Long-Non-coding RNA Causes Global Alterations in the Genome and Proteome in Cancer and Other DisordersJyotsna Singh, Aastha Pandey, Sharad Awasthi, Sarat Kumar Kottarath, Mohd Farhan, Yogesh Srivastava · 2025 · Springer eBooks
- Alternative splicing and the aging brain in AfrAbia: New frontiers in dementia researchSuliyat Abiodun Aremu · 2025 · IBRO Neuroscience Reports
- Proteo-transcriptomic reprogramming and resource reallocation define the aging mammalian brainNisha Hemandhar Kumar, Verena Kluever, Svenja V. Kaufmann, Cornelius Bergmann, Kanaan Mousaei, Miguel Tomas, Miguel Correa Marrero, Avika Chopra, Misa Hirose, Mercè Pallàs et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Tau protein isoforms in neuropathological aging: Gerosuppressors, gerogenes or just travel companionsJesús Ávila, Félix Hernández, José Viña · 2025 · Geromedicine
- Identification of small ubiquitin-related modifier (SUMO)-related genes-based biomarkers in Alzheimer’s disease based on bioinformatics analysisPeng Chen, Mengting Fan, Hailiang Lin, Zhong Chen, Qiuyang Zhang, Yunfan Cheng, Jing Xu · 2026 · Scientific Reports
- Estudi bioinformàtic de la funcionalitat i conservació de l’splicing alternatiuJordi Morata · 2012 · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
- Additional file 1 of Clusters of co-abundant proteins in the brain cortex associated with fronto-temporal lobar degenerationClaire Bridel, Juami H. M. van Gils, Suzanne S. M. Miedema, Jeroen J.M. Hoozemans, Yolande A.L. Pijnenburg, August B. SMIT, Annemieke J.M. Rozemüller, Sanne Abeln, Charlotte Elisabeth Teunissen · 2024 · Figshare
- Additional file 1 of Functional enrichment of alternative splicing events with NEASE reveals insights into tissue identity and diseasesZakaria Louadi, Elkjaer, Maria L., Klug, Melissa, Chit Tong Lio, Amit M. Fenn, Zsolt Illés, Dario Bongiovanni, Baumbach, Jan, Tim Kacprowski, List, Markus et al. · 2021 · Figshare
- Additional file 8 of Functional enrichment of alternative splicing events with NEASE reveals insights into tissue identity and diseasesZakaria Louadi, Maria L. Elkjaer, Klug, Melissa, Chit Tong Lio, Amit M. Fenn, Zsolt Illés, Dario Bongiovanni, Baumbach, Jan, Tim Kacprowski, List, Markus et al. · 2021 · Figshare
- A combination of differential expression and network connectivity analyses identifies a common set of RNA splicing and processing genes altered with age across human tissuesCaio M.P.F. Batalha, André Fujita, Nadja Cristhina de Souza-Pinto · 2025 · Aging
- Exploring Splicing‐Energy Axis Associations to Diet and LongevityStefano Donegà, Myriam Gorospe, Luigi Ferrucci · 2025 · Aging Cell
- Post-transcriptional regulation in intervertebral disc degenerationXinyu Li, Huaizhen Liang, Zhi Du, Rui Shi, Yu Song, Cao Yang · 2026 · Genes & Diseases
- Brain aging mediates region-specific transcriptomic alterationsAdel B Alharbi · 2026 · Biosystems
- Rôle cellulaire et développemental du transporteur lysosomal PQLC2 dans un modèle murinSolène Lebrun · 2023 · theses.fr (ABES)
- mRNA enhanced cell therapy and reverse agingVibha Dwivedi, Mukulika Ray, Anand Kumar Singh · 2026 · Elsevier eBooks
- Locus-specific LINE-1 mRNA expression reflects cell-type- and stimulus-specific senescence statesMinh N. Tran, Sihan Liu, Melody Baddoo, Emily C. Stow, Sudesh K Srivastav, Victoria P. Belancio · 2026 · Nucleic Acids Research
- HnRNPAB -targeted antisense oligonucleotides ameliorate tau pathology and cognitive deficits by modulating Alzheimer’s disease-associated alternative splicingTao Jiang, Xingjun Xu, Yaqiong Yu, Caixin Zhu, Chao Ma, Yu Tang, Lingxia Min, Mingliang Tan, Jialin Bai, Zhou Feng et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Normal spermatogenesis in older men is associated with compensatory transcriptome changesYihan Wang, Sven Berres, Henrike Krenz, Tobias Tekath, Marius Wöste, Sarah Sandmann, Amelie Körtje, Anna Henrich, Nicole Terwort, Frank Tüttelmann et al. · 2026 · GeroScience
- Compartment-specific inhibition of cytosolic Cathepsin B mitigates microglial senescence in the aging brainSimeng Zhang, Chen Zhang, Jian Mao, Junjun Ni · 2026 · Pharmacological Research
- Caloric restriction drives age-dependent and integrated remodeling of RNA processing and lipid composition in mouse brainSpencer Tye, Josef P. Clark, Andrew Engeler, Anshit Singh, Rozalyn M. Anderson, Timothy W. Rhoads · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Transitional Neuronal States Suggest Divergent Trajectories of Resilience and Neurodegeneration in an Alzheimer’s Disease Mouse ModelYun‐Juan Chang, Philip H. Stavrides, Harshitha Pidikiti, Kyrillos W. Ibrahim, Ju‐Hyun Lee, Martin J. Berg, Kuldeep Singh Sachdeva, Stephen D. Ginsberg · 2026 · Brain Sciences
- BindingDB Entry 50040709: Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.BindingDB · 2013 · UC San Diego
- BindingDB Entry 50044700: Hydroxybenzothiophene Ketones Are Efficient Pre-mRNA Splicing Modulators Due to Dual Inhibition of Dyrk1A and Clk1/4.BindingDB · 2016 · UC San Diego