Alignathon: a competitive assessment of whole-genome alignment methods
Open accessPublished version of a preprint
Abstract
Multiple sequence alignments (MSAs) are a prerequisite for a wide variety of evolutionary analyses. Published assessments and benchmark data sets for protein and, to a lesser extent, global nucleotide MSAs are available, but less effort has been made to establish benchmarks in the more general problem of whole-genome alignment (WGA). Using the same model as the successful Assemblathon competitions, we organized a competitive evaluation in which teams submitted their alignments and then assessments were performed collectively after all the submissions were received. Three data sets were used: Two were simulated and based on primate and mammalian phylogenies, and one was comprised of 20 real fly genomes. In total, 35 submissions were assessed, submitted by 10 teams using 12 different alignment pipelines. We found agreement between independent simulation-based and statistical assessments, indicating that there are substantial accuracy differences between contemporary alignment tools. We saw considerable differences in the alignment quality of differently annotated regions and found that few tools aligned the duplications analyzed. We found that many tools worked well at shorter evolutionary distances, but fewer performed competitively at longer distances. We provide all data sets, submissions, and assessment programs for further study and provide, as a resource for future benchmarking, a convenient repository of code and data for reproducing the simulation assessments.
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Different genome aligners frequently give different results.
“different aligners frequently give different results14”
From Progressive Cactus is a multiple-genome aligner for the thousand-genome era (2020) · cites this paper as [14]
The version of Cactus available in 2012 performed very well in the Alignathon.
“The version of Cactus available in 2012 performed very well in the Alignathon14, an evaluation of genome aligners.”
From Progressive Cactus is a multiple-genome aligner for the thousand-genome era (2020) · cites this paper as [14]
The Alignathon simulated datasets have a known truth set, providing a way to compare Progressive Cactus against other genome aligners.
“The Alignathon simulated datasets14 have been aligned with many competing genome aligners and have a known truth set, providing a way to compare Progressive Cactus against other genome aligners.”
From Progressive Cactus is a multiple-genome aligner for the thousand-genome era (2020) · cites this paper as [14]
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Progressive Cactus is a multiple-genome aligner for the thousand-genome era
Armstrong, J., Hickey, G., Diekhans, M., Fiddes, I. T., Novak, A. M., Deran, A., Fang, Q., Xie, D., Feng, S., Stiller, J., et al. (2020) · Nature · doi:10.1038/s41586-020-2871-y · Cited by 586 · see citing works
Self-citationWhole-Genome Alignment: Methods, Challenges, and Future Directions
Saada, B., Zhang, T., Siga, E., Zhang, J., & Magalhães Muniz, M. M. (2024) · Applied Sciences · doi:10.3390/app14114837 · Cited by 15 · see citing works
- Authors
- Earl, D., Nguyen, N., Hickey, G., Harris, R. S., Fitzgerald, S., Beal, K., Seledtsov, I., Molodtsov, V., Raney, B. J., Clawson, H., Kim, J., Kemena, C., Chang, J.-M., Erb, I., Poliakov, A., Hou, M., Herrero, J., Kent, W. J., Solovyev, V., Darling, A. E., Ma, J., Notredame, C., Brudno, M., Dubchak, I., Haussler, D., & Paten, B.
- Affiliations
- University of California, Santa Cruz (US)
- McGill University (CA)
- Pennsylvania State University (US)
- European Bioinformatics Institute (GB)
- Konkuk University (KR)
- Universitat Pompeu Fabra (ES)
- Centre National de la Recherche Scientifique (FR)
- Joint Genome Institute (US)
- Northern Illinois University (US)
- University of Technology Sydney (AU)
- University of Illinois Urbana-Champaign (US)
- University of Toronto (CA)
- Lawrence Berkeley National Laboratory (US)
- Howard Hughes Medical Institute (US)
- ORCID
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2014-10-01
- Volume
- 24
- Issue
- 12
- Pages
- 2077-2089
- ISSN
- 1088-9051 (ISSN-L)
- 1549-5469
- PMC
- PMC4248324
- OpenAlex
- W2141274012
- Cited by
- 113
- References
- 1
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 4 · 2023: 10 · 2022: 7 · 2021: 13 · 2020: 14 · 2019: 9 · 2018: 14 · 2017: 9 · 2016: 12 · 2015: 8 · 2014: 1
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genome Research (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- HighWire Press Open Archive (submittedVersion)
- UTS ePRESS (University of Technology Sydney) (submittedVersion)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion, cc-by)
- Funders
- NIH (2U41 HG002371-13, R21HG006464, R01HG007352, R15HG005913)
- NHGRI/NIH (5U01HG004695)
- NSF (1054309, 1262575)
- Spanish Ministry of Economy and Competitiveness (BFU2011-28575, SEV-2012-0208)
- Secretariat of Universities and Research, Department of Economy and Knowledge of the Government of Catalonia (2009 SGR 951)
- European Research Council (232947)
- Wellcome Trust (WT095908)
- European Community's Seventh Framework Programme (222664)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genome Rearrangement Algorithms
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Keywords
- whole-genome alignment, multiple sequence alignment, benchmarking, simulated genomes, primate phylogeny, mammalian phylogeny, gene duplication, phylogenetic distance
- MeSH terms
- Animals, Computer Simulation, Humans, Mammals, Phylogeny, Software, Reproducibility of Results, Sequence Alignment, Genome, Computational Biology, Genomics, Genome-Wide Association Study, Datasets as Topic
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