Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networks
Sebestyén, Endre, Singh, Babita, Miñana, Belén, Pagès, Amadís, Mateo, Francesca, Pujana, Miguel Angel, Valcárcel, Juan, Eyras, Eduardo·2016·Genome Research
Cited by (277)
Items 201–277 of 277
- Discovery of the U2AF1-UHM Inhibitor That Possesses Anti-Leukemia Activity In VitroAmol D. Patil, Mona Kazemi Sabzvar, Xinrui Yuan, Daniel Mohr Collier, Chao‐Yie Yang · 2025 · ACS Medicinal Chemistry Letters
- Expression analysis of androglobin and its influence on the transcriptome in cancerCarina Osterhof, Michel Seiwert, Stefan Mündnich, Teng Wei Koay, Elena Porto, Glen Kristiansen, David Hoogewijs, Thomas Hankeln · 2025 · Gene
- Age-related aberrant alternative splicing as a prognostic tool in older breast cancer patientsMengxin Chen, Taiping Xiao, Ke Hao, Chun Ye, Yu Fan, Jianbin Su, Shixin Yang, Yun Feng, Huaimeng Xu, Shiting Fu et al. · 2025 · Communications Biology
- Large-scale analysis reveals splicing biomarkers for tuberculosis progression and prognosisHongli Lai, Mengyuan Lyu, Hongxia Ruan, Yang Liu, Tangyuheng Liu, Shuting Lei, Yuling Xiao, Shu Zhang, Binwu Ying · 2024 · Computers in Biology and Medicine
- Whole‑exome sequencing insights into synchronous bilateral breast cancer with discordant molecular subtypesShi-Han Hu, Bo Gao, Zhengjin Li, Ya-Chen Yuan · 2024 · Oncology Letters
- Cleavage and Polyadenylation-Specific Factor 4 (CPSF4) Expression Is Associated with Enhanced Prostate Cancer Cell Migration and Cell Cycle Dysregulation, In VitroMuhammad Choudhry, Yaser Gamallat, Sunita Ghosh, Tarek A. Bismar · 2023 · International Journal of Molecular Sciences
- Tumorigenic de-differentiation: the alternative splicing wayDebleena Ray, David Mark Epstein · 2020 · Molecular & Cellular Oncology
- HSPA5 regulates the expression and alternative splicing of inflammatory and immune response genes.Heng Fan, Linping Xue, Yujin Liu, Dongmei Zuo, Fei Gao, Huarong Li, Lijuan Zhang, Zhexing Shou · 2021 · Research Square
- Systematic Characterization of Splicing Dysregulation in Pan Solid Tumor TranscriptomeJingru Sui, Dan Huai Guo, Wen Xiao, Lei Zhou, Yue Huang, Haoyu Yu, Jinyu Chen, Zhaoqi Liu · 2024 · Advanced Science
- Transcripts of splicing factors with time-varying associations with survival outcomes in colorectal cancerYajun Yu · 2025 · American Journal of Cancer Research
- Genome-Wide Identification of Microglia-Related RNA-Binding Proteins and Regulated Alternative Splicing in Spinal Cord InjuryWenbo Gu, Xiao Zhang, Xiaoya Yuan, Lihong Hu, Xusheng Li, Di Luo, Haifeng Yuan · 2025 · ACS Omega
- CELF1 promotes aerobic glycolysis and an aggressive phenotype in ER-positive breast cancer via GLUT1 regulationJinyu Li, Ning Wang, Jianlei Bi, Mei-Hua Guo, Bingbing Xu, Ge-Na Huang · 2025 · Frontiers in Genetics
- ZC3H12D and DDX5 Antagonistically Regulate Cyclin D1 mRNA Stability and Cell Cycle Progression in Breast CancerLiang Sun, Xueting Liu, Wenbao Lu · 2025 · Cancer Medicine
- CIRBP exerts neuroprotective effects in ischemic injury by inhibiting IFN-I signalingDang Tang, Jiang Long, Bibo Gao, Zhongkun Ren · 2026 · Life Sciences
- An Integrative RNA Spliceosomic Landscape of Pancreatic Neuroendocrine Tumors Identifies Clinically Relevant Molecular SubgroupsRicardo Blázquez‐Encinas, Víctor García‐Vioque, Andrea Mafficini, Luca Landoni, Daniel Ruiz-Palacios, Laura Gutiérrez-Camacho, María Trinidad Moreno-Montilla, Nicolas Alcala, Sebastián Ventura, Eduardo Eyras et al. · 2026 · Endocrine Pathology
- Increasing evidence for the presence of alternative proteins in human tissues and cell linesRodrigo Fernandes Ramalho, Dirce Maria Carraro · 2017 · Applied cancer research/Applied Cancer Research
- Interactive Alternative Splicing Analysis of Human Stem Cells Using psichomicsNuno Saraiva-Agostinho, Nuno L. Barbosa‐Morais · 2020 · Methods in molecular biology
- Two novel RNA-binding proteins identification through computational prediction and experimental validationJuan Xie, Xiaoli Zhang, Jinfang Zheng, Xu Hong, Xiaoxue Tong, Xudong Liu, Yaqiang Xue, Xuelian Wang, Yi Zhang, Shiyong Liu · 2021 · Genomics
- The Role of Alternative Splicing in Cancer: Regulatory Mechanism, Therapeutic Strategy, and Bioinformatics ApplicationYao‐Jie Pan, Bowen Liu, Dong‐Sheng Pei · 2022 · DNA and Cell Biology
- Unraveling immune heterogeneity across pan-cancer and deep insights in lung adenocarcinoma based on alternative splicingYuquan Wang, Erliang Guo, Min Zou, Chen Lv, Yanrui Cui, Songmei Zhai, Shaocong Sang, Kai Xiong, Xiuqi Yang, Shuping Zhuang et al. · 2024 · Journal of Leukocyte Biology
- Modularized Perturbation of Alternative Splicing Across Human CancersYabing Du, Shoumiao Li, Ranran Du, Ni Shi, Seiji Arai, Sai Chen, Aijie Wang, Yu Zhang, Zhaoyuan Fang, Tengfei Zhang et al. · 2019 · Frontiers in Genetics
- Tumor Niche Disruption and Metastasis: The Role of Epithelial-Mesenchymal Transition (EMT)Rita Zilhão, Hélia Neves · 2019 · Learning materials in biosciences
- Alternative Splicing Changes As Drivers Of CancerHéctor Climente-González, Eduard Porta‐Pardo, Adam Godzik, Eduardo Eyras · 2017 · Zenodo (CERN European Organization for Nuclear Research)
- Dysregulated Alternative Splicing Landscape Identifies Intron Retention as a Hallmark and Spliceosome as a Therapeutic Vulnerability in Aggressive Prostate CancerDingxiao Zhang, Qiang Hu, Yibing Ji, Hsueh‐Ping Chao, Amanda Tracz, Jason S. Kirk, Silvia Buonamici, Ping Zhu, Jianmin Wang, Song Liu et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- A Localization Screen Reveals Translation Factories and Widespread Co-Translational Protein TargetingRacha Chouaib, Adham Safieddine, Xavier Pichon, Oh Sung Kwon, Aubin Samacoïts, Abdel-Meneem Traboulsi, Nikolay Tsanov, Marie-Cécile Robert, Ina Poser, Christophe Zimmer et al. · 2019 · SSRN Electronic Journal
- Identification of a novel RNA modifications-related model to improve bladder cancer outcomes in the framework of predictive, preventive, and personalized medicineZiying Zhang, Peng Chen, Fangyi Liu, Censhan Lin, Ru Deng, Liyan Wu, Yun Cao, Jing‐Ping Yun, Yuhua Huang · 2022 · Research Square
- BCLAF1 links RNA splicing to ATF4-dependent metabolic adaptation in acute myeloid leukemiaLaura López-Hernández, Stephanie J. Crowley, Sara Cea-Sánchez, Ricardo de Arellano, Neetij Krishnan, Patrick Toolan-Kerr, Lynn S. White, Domenico Ignoti, Emily Soto-Hidalgo, Stefano Gustincich et al. · 2026 · Science Advances
- Large-scale study of rna processing alterations in multiple cancersBabita Singh · 2017 · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
- Characterization of clinically relevant RNA alterations for personalized cancer medicineTrincado Alonso, Juan José Quirós Luis · 2019 · Repositori digital de la UPF (Universitat Pompeu Fabra)
- Peer Review #1 of "Identification of prognostic splicing factors and exploration of their potential regulatory mechanisms in pancreatic adenocarcinoma (v0.1)"2020 · PeerJ
- ASpediaFI: Functional interaction analysis of alternative splicing eventsDoyeong Yu, Kyubin Lee, Daejin Hyung, Soo Young Cho, Charny Park · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- RNA-binding protein FXR1 drives cMYC translation by mRNA circularization through eIF4F recruitment in ovarian cancerJasmine George, Yongsheng Li, Deepak Parashar, Shirng‐Wern Tsaih, Prachi Gupta, Anjali Geethadevi, Ishaque P. Kadembari, Chandrima Ghosh, Yunguang Sun, Ramani Ramchandran et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Splicing and Alternative Splicing and the Impact of MechanicsClaudia Tanja Mierke · 2020 · Biological and medical physics, biomedical engineering
- Systematic Analysis of the Function and Prognostic Value of RNA-Binding Proteins in Hepatocellular CarcinomaTONG WU, Zhiyun Yang, Yuying Yang, Yuyong Jiang, Peipei Meng, Huimin Liu, Qiaoli Zhang · 2020 · Research Square
- Targeted exome sequencing for the identification of common mutational signatures and potential driver mutations for brain metastases and prognosis.Dainan Zhang, Xi Wang, Shunchang Ma, Peiliang Li, Fei Xue, Beibei Mao, Xiudong Guan, Wenjianlong Zhou, Jiayi Peng, Kun Su et al. · 2021 · PubMed Central
- Characterization of the relationship between two RBM5 family membersJulie J. Loiselle · 2017 · Lu Zone Ul (Laurentian University)
- MBNL1 and RBFOX1 co-regulate alternative splicing events transcriptome-wide through a conserved buffering mechanismMelissa A. Hale, Joseph Ellis, Ryan C. Meng, Sunny McDaniel, Amy E. Mahady, Stacey D. Wagner, Jared I. Richardson, Ona L. McConnell, Eric T. Wang, J. Andrew Berglund · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- RBM10 Interacts with CTBNNBIP1 and Represses Lung Adenocarcinoma Progression Through the Wnt/β- catenin PathwayYingyue Cao, Xin Wang, Qingwei Meng, Jianxiong Geng, Shanqi Xu, Yaoguo Lang, Yongxu Zhou, Lishuang Qi, Zijie Wang, Zixin Wei et al. · 2021 · Research Square
- A convergent malignant phenotype in B-cell acute lymphoblastic leukemia involving the splicing factor SRRM1Adrià Closa, Marina Reixachs‐Solé, Antonio C. Fuentes-Fayos, Katharina E. Hayer, Juan Luis Melero, Fabienne R. S. Adriaanse, Romy S. Bos, Manuel Torres-Diz, Stephen P. Hunger, Kathryn G. Roberts et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Identification of Necroptosis-related Subtypes, Construction of a Prognosis Model, and Characterization of Immune Infiltration in Colon Cancer.Jianli Chen, Yu-ning Qin, Lei Yang, Xiangen Jia, Guozhi Zhang · 2022 · Research Square
- A convergent malignant phenotype in B-cell acute lymphoblastic leukemia involving the splicing factor SRRM1Adrià Closa, Marina Reixachs‐Solé, Antonio C. Fuentes-Fayos, Katharina E. Hayer, Juan Luis Melero, Fabienne R. S. Adriaanse, Romy S. Bos, Manuel Torres-Diz, Stephen P. Hunger, Kathryn G. Roberts et al. · 2022 · Research Square
- Identification of necroptosis-Related subtypes,the development of a prognosis model, and characterization of tumor microenvironment infiltration in Hepatocellular carcinomaGuozhi Zhang, Xiangen Jia, Yu-ning Qin · 2022 · Research Square
- Peer Review #2 of "Identification of prognostic splicing factors and exploration of their potential regulatory mechanisms in pancreatic adenocarcinoma (v0.2)"2020 · PeerJ
- Peer Review #2 of "Identification of prognostic splicing factors and exploration of their potential regulatory mechanisms in pancreatic adenocarcinoma (v0.1)"2020 · PeerJ
- Desregulación del splicing del gen PALB2 en cáncer de mama hereditarioAlberto Valenzuela‐Palomo · 2022
- Predicting the effects of cultivation condition on gene regulation in Escherichia coli by using deep learningMun Su Kwon, Joshua Julio Adidjaja, Hyun Uk Kim · 2023 · Computational and Structural Biotechnology Journal
- A Systematic Identification of RBPs Driving Aberrant Splicing in CancerMarian Gimeno, César Lobato‐Fernández, Ane San Martín, Ana Anorbe, Ángel Rubio, Juan A. Ferrer-Bonsoms · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Performing Cancer Diagnosis via an Isoform Expression Ranking-based LSTM ModelÓscar Reyes, Eduardo Pérez · 2023 · ACM Transactions on Intelligent Systems and Technology
- DeepRBP: A novel deep neural network for inferring splicing regulationJoseba Sancho-Zamora, Juan A. Ferrer-Bonsoms, Danel Olaverri-Mendizabal, Fernando Carazo, Luis V. Valcárcel, Idoia Ochoa · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Chemokine‑ and chemokine receptor-based subtypes predict prognosis, immunotherapy and chemotherapy response in colorectal cancer patientsWenjie Zhu, Shimin Zhao, Xiufeng Cheng, Changlei Wu, Zitao Liu, Jun Huang · 2024 · International Immunopharmacology
- A Systematic Identification of RBPs Driving Aberrant Splicing in CancerCésar Lobato‐Fernández, Marian Gimeno, Ane San Martín, Ana Anorbe, Ángel Rubio, Juan A. Ferrer-Bonsoms · 2024 · Research Square
- An integrative RNA spliceosomic landscape of pancreatic neuroendocrine tumors unveils novel clinicomolecular associationsRicardo Blázquez‐Encinas, Víctor García‐Vioque, Andrea Mafficini, Luca Landoni, María Trinidad Moreno-Montilla, Nicolas Alcala, Sebastián Ventura, Eduardo Eyras, Salvatore Paiella, Roberto Salvia et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- UBE2N modulates osteoclast differentiation via BTK-PLCγ2-Ca2+ signaling pathway to promote osteoporosisYiqing Chen, Ruixue Ying, Liya Ai, Fang Dai, Qiu Zhang, Ping Wang, Fuhua Chen · 2025 · Experimental Gerontology
- Aberrant alternative splicing in alcoholic hepatitis: regulatory roles of RBPs and sQTLsJinjiang Zhao, Jie Jun Cheng, Shaohua Liang, Wei Guo, Beibei Zhao, Huipeng Zhang, Xianghuang Mei, Ning Zhang, Meifang Sheng · 2025 · BMC Gastroenterology
- Comprehensive analysis of aberrant alternative splicing and RNA binding proteins associated with age-related sensorineural hearing lossWei Yu, Zeping Qin, XinYu Liang, Xianbai Zhu, Guojing Tan, Baiyang Ren, Yanghong Xiang, Can Zou, Xueqin Zhou, Hongyang Wang et al. · 2025 · Scientific Reports
- Additional file 14 of Alternative splicing level related to intron size and organism complexityYang, Pengcheng, Depin Wang, Kang, Le · 2021 · Figshare
- Additional file 12 of Alternative splicing level related to intron size and organism complexityYang, Pengcheng, Depin Wang, Kang, Le · 2021 · Figshare
- Additional file 8 of Alternative splicing level related to intron size and organism complexityYang, Pengcheng, Depin Wang, Kang, Le · 2021 · Figshare
- Additional file 16 of Alternative splicing level related to intron size and organism complexityYang, Pengcheng, Depin Wang, Kang, Le · 2021 · Figshare
- Additional file 13 of Alternative splicing level related to intron size and organism complexityYang, Pengcheng, Depin Wang, Kang, Le · 2021 · Figshare
- Additional file 10 of Alternative splicing level related to intron size and organism complexityYang, Pengcheng, Depin Wang, Kang, Le · 2021 · Figshare
- Additional file 11 of Alternative splicing level related to intron size and organism complexityYang, Pengcheng, Depin Wang, Kang, Le · 2021 · Figshare
- Additional file 3 of Alternative splicing level related to intron size and organism complexityYang, Pengcheng, Depin Wang, Kang, Le · 2021 · Figshare
- Overexpression of USP36 stabilizes RBM28 via deubiquitination, leading to p53 suppression and poor prognosis in colorectal cancerDimitra Sofia Georgiou, Ioanna Maria Karagianni · 2023 · Archive of International Journal of Cancer and Allied Science
- The SF3B1 inhibitor pladienolide B massively inhibits DNA damage signaling and repair and counteracts resistance to platinum salts in Non-Small Cell Lung CancerNour Jamal-El-Hussein, Shipra Chaudhary, Élodie Montaudon, Fariba Némati, Aurélie Genoux, Hélène Polvèche, Rania El Botty, Caroline Barette, Tao Jia, Didier Auboeuf et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- The Landscape and Regulatory Mechanisms of Aberrant Alternative Splicing Events in AdenomyosisY. Zhang, Z. Cui · 2025 · Molecular Biology
- Integrative Analysis of Alternative Splicing Regulation Reveals Genetic and RBP-Mediated Mechanisms in Endometriosis PathogenesisZhujie Wang, Haiwei Yan, Lihua Zhu, Shanshan Ni, Lili Qian, Mengjia Yu, Juan Yu · 2026 · Reproductive Sciences
- Études d'association génome entier guidées par des réseauxHéctor Climente-González · 2020 · theses.fr (ABES)
- Systematic imaging of single transcripts and polysomes reveals a widespread transport mechanism dependent on nascent translationAdham Safieddine · 2019
- Approche à large échelle visant à détecter de nouveaux régulateurs de l'épissage alternatif au cours de la transition épithélio-mésenchymateuse.Jean-Philippe Villemin · 2020 · theses.fr (ABES)
- The Role of Convergent Transcription in Regulating Alternative Splicing : Targeted Epigenetic Modification via Repurposed CRISPR/Cas9 System and Its Impact on Alternative Splicing ModulationJia Yi · 2020 · theses.fr (ABES)
- Integrated RNA-seq and sQTL analysis reveal immune and splicing regulatory features underlying relapse and remission after treatment of Graves’ diseaseYang Wu, Jie Liu, Yu Yang, Keping Chen, Fei Hua, K J Wang · 2026 · Frontiers in Endocrinology
- NF1 splicing reprograms ERα signaling to promote luminal breast cancer progressionPatrick S. Dischinger, Ian Beddows, Sophia Agrusa, Marie Adams, Emily Wolfrum, Carrie R. Graveel, Matthew R. Steensma · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- MBNL1-mediated alternative splicing in cancer: underlying mechanism, isoform regulation, and translational perspectivesHuidan Tan, Rongyan Zhao, Bo Liu, Leilei Fu · 2026 · Frontiers in Molecular Biosciences
- MBNL1-dependent alternative splicing promotes neuronal differentiation through regulation of NUMA1 exon 16 during fibroblast-to-neuron reprogrammingJ Li, Qiu-Shuang Long, Ruoqi Zhang, Bing-Lin Zhu · 2026 · Frontiers in Cell and Developmental Biology
- RBFOX3 is associated with neuronal-like phenotypic transition in recurrent glioblastomaXiaomeng Zhang, Jingru Sui, Haoyuan Sun, Ruichao Chai, Z H Liu, Jiguang Wang · 2026 · BMC Cancer
- Proteomic Profiling of Endometriosis and Ovarian Endometrioid Carcinoma: A Preliminary Exploratory StudyQi Xue, Xianzhong Cheng, Qian Zhao, Li Xiao, Xuening Wang, Luxin Ye, Hongxia Xu, Na Yan, Lin Liu, Xiaohong Yang et al. · 2026 · Technology in Cancer Research & Treatment