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Cited by 983

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Automated De Novo Identification of Repeat Sequence Families in Sequenced Genomes

Open access
Bao, Zhirong, Eddy, Sean R.·2002·Genome Research

Abstract

Repetitive sequences make up a major part of eukaryotic genomes. We have developed an approach for the de novo identification and classification of repeat sequence families that is based on extensions to the usual approach of single linkage clustering of local pairwise alignments between genomic sequences. Our extensions use multiple alignment information to define the boundaries of individual copies of the repeats and to distinguish homologous but distinct repeat element families. When tested on the human genome, our approach was able to properly identify and group known transposable elements. The program,RECON, should be useful for first-pass automatic classification of repeats in newly sequenced genomes. [The following individuals kindly provided reagents, samples, or unpublished information as indicated in the paper: R. Klein.]

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Metadata

Authors
Bao, Z., & Eddy, S. R.
Venue
Genome Research
Published
2002-07-19
Volume
12
Issue
8
Pages
1269-1276
ISSN
  • 1088-9051 (ISSN-L)
  • 1549-5469
OpenAlex
W2151899848
Cited by
983
References
1
Type
posted content
Language
en
Open access
bronze

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