NMDA signaling in CA1 mediates selectively the spatial component of episodic memory
Open accessAbstract
Recent studies focusing on the memory for temporal order have reported that CA1 plays a critical role in the memory for the sequences of events, in addition to its well-described role in spatial navigation. In contrast, CA3 was found to principally contribute to the memory for the association of items with spatial or contextual information in tasks focusing on spatial memory. Other studies have shown that NMDA signaling in the hippocampus is critical to memory performance in studies that have investigated spatial and temporal order memory independently. However, the role of NMDA signaling separately in CA1 and CA3 in memory that combines both spatial and temporal processing demands (episodic memory) has not been examined. Here we investigated the effect of the deletion of the NR1 subunit of the NMDA receptor in CA1 or CA3 on the spatial and the temporal aspects of episodic memory, using a behavioral task that allows for these two aspects of memory to be evaluated distinctly within the same task. Under these conditions, NMDA signaling in CA1 specifically contributes to the spatial aspect of memory function and is not required to support the memory for temporal order of events.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
CA1 NMDA signaling is essential for processing spatial but not temporal information in an episodic-like context.
“This suggests that the CA1 NMDA signaling is essential for the processing of spatial, but not temporal, information in an episodic-like context.”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Place et al., 2012
Selective knockout of the NMDA-R subunit NR1 in the hippocampal CA1 region impaired where but not when memory in mice.
“selective knockout of the NMDA-R subunit NR1 in the hippocampal CA1 region impaired where, but not when, memory in mice”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Place et al., 2012
Mice with the same NR1 knockout in the CA3 region exhibited intact where and when memory.
“mice with the same knockout, but in the CA3 region, exhibited intact where and when memory”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Place et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 31 · Cited by 46
- Authors
- Place, R., Lykken, C., Beer, Z., Suh, J., McHugh, T. J., Tonegawa, S., Eichenbaum, H., & Sauvage, M. M.
- Affiliations
- Boston University (US)
- Massachusetts Institute of Technology (US)
- RIKEN Center for Brain Science (JP)
- Corresponding author
- Sauvage, Magdalena M.
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2012-03-14
- Volume
- 19
- Issue
- 4
- Pages
- 164-169
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- PMC
- PMC3312619
- OpenAlex
- W2042522288
- Cited by
- 46
- References
- 31
- Citations by year
- 2026: 5 · 2025: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 5 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 8 · 2012: 2
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Learning & Memory (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (P50MH060450, MH-60450)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- NMDA receptor signaling, NR1 subunit, CA1, CA3, hippocampus, episodic memory, spatial memory, temporal order memory, sequence memory
- MeSH terms
- Animals, Male, Mice, Inbred C57BL, RNA, Messenger, Signal Transduction, Receptors, N-Methyl-D-Aspartate, N-Methylaspartate, In Situ Hybridization, Mice, Knockout, Mice, CA1 Region, Hippocampal, CA3 Region, Hippocampal, Memory, Episodic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
