Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay
Open accessAbstract
Previous in vivo electrophysiological studies suggest that the anterior cingulate cortex (ACgx) is an important substrate of novel object recognition (NOR) memory. However, intervention studies are needed to confirm this conclusion and permanent lesion studies cannot distinguish effects on encoding and retrieval. The interval between encoding and retrieval tests may also be a critical determinant of the role of the ACgx. The current series of experiments used micro-infusion of the GABAA receptor agonist, muscimol, into ACgx to reversibly inactivate the area and distinguish its role in encoding and retrieval. ACgx infusions of muscimol, before encoding did not alter NOR assessed after a delay of 20 min or 24 h. However, when infused into the ACgx before retrieval muscimol impaired NOR assessed after a delay of 24 h, but not after a 20-min retention test. Together these findings suggest that the ACgx plays a time-dependent role in the retrieval, but not the encoding, of NOR memory, neuronal activation being required for the retrieval of remote (24 h old), but not recent (20 min old) visual memory.
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Pharmacological inhibition of the mPFC with muscimol before the sample trial has no effect in the NOP test.
“Pharmacological inhibition of the mPFC with muscimol, a GABAA-R agonist, also had no effect in the NOP test when infused before the sample trial (Neugebauer et al., 2018; Pezze et al., 2017).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Pezze et al., 2017
Pre-test microinfusions of muscimol into the rat ACC impair NOP memory tested after 24 hours, but not after 20 minutes, implying the ACC is involved in retrieval of NOP in a time-dependent manner.
“In addition, pre-test microinfusions of muscimol into the rat ACC impaired the NOP memory tested after 24 hours, but not 20 min, implying the ACC is involved in the retrieval of NOP in a time-dependent manner (Pezze et al., 2017).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Pezze et al., 2017
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References 46 · Cited by 35
- Authors
- Pezze, M. A., Marshall, H. J., Fone, K. C., & Cassaday, H. J.
- Affiliations
- University of Nottingham (GB)
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2017-06-15
- Volume
- 24
- Issue
- 7
- Pages
- 310-317
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- PMC
- PMC5473111
- OpenAlex
- W2611148813
- Cited by
- 35
- References
- 46
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 9 · 2019: 3 · 2018: 6
- Type
- posted content
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Learning & Memory (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Nottingham ePrints (University of Nottingham) (submittedVersion, cc-by-nc)
- Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by-nc)
- HighWire Press Open Archive (submittedVersion)
- Funders
- BBSRC (BB/K004980/1)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- anterior cingulate cortex, novel object recognition memory, memory retrieval, memory encoding, muscimol, GABA-A receptor agonists, retention delay, visual memory
- MeSH terms
- Analysis of Variance, Animals, Discrimination, Psychological, Exploratory Behavior, Gyrus Cinguli, Male, Microinjections, Muscimol, Reaction Time, Mental Recall, Time Factors, Reproducibility of Results, Rats, Wistar, Recognition, Psychology, Rats, GABA-A Receptor Agonists
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