Endurance factors improve hippocampal neurogenesis and spatial memory in mice
Open accessAbstract
Physical activity improves learning and hippocampal neurogenesis. It is unknown whether compounds that increase endurance in muscle also enhance cognition. We investigated the effects of endurance factors, peroxisome proliferator-activated receptor δ agonist GW501516 and AICAR, activator of AMP-activated protein kinase on memory and neurogenesis. Mice were injected with GW for 7 d or AICAR for 7 or 14 d. Two weeks thereafter mice were tested in the Morris water maze. AICAR (7 d) and GW improved spatial memory. Moreover, AICAR significantly, and GW modestly, elevated dentate gyrus neurogenesis. Thus, pharmacological activation of skeletal muscle may mediate cognitive effects.
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Mice injected with skeletal muscle endurance factors had elevated hippocampal neurogenesis and increased spatial memory.
“Indeed, mice injected with skeletal muscle endurance factors had elevated levels of hippocampal neurogenesis and increased spatial memory (Kobilo et al., 2010).”
From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Kobilo et al., 2010
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References 45 · Cited by 114
- Authors
- Kobilo, T., Yuan, C., & van Praag, H.
- Affiliations
- National Institutes of Health (US)
- National Institute on Aging (US)
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2011-01-18
- Volume
- 18
- Issue
- 2
- Pages
- 103-107
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- PMC
- PMC3032576
- OpenAlex
- W2169806530
- Cited by
- 114
- References
- 45
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 7 · 2023: 2 · 2022: 5 · 2021: 7 · 2020: 1 · 2019: 10 · 2018: 12 · 2017: 10 · 2016: 11 · 2015: 9 · 2014: 8 · 2013: 5 · 2012: 12
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Learning & Memory (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Johns Hopkins University
- National Institutes of Health
- National Institute on Aging
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampal neurogenesis, spatial memory, GW501516, AICAR, AMPK, PPARδ, skeletal muscle activation, dentate gyrus, cognitive enhancement, physical activity
- MeSH terms
- Adenylate Kinase, Aminoimidazole Carboxamide, Animals, Female, Hippocampus, Hypoglycemic Agents, Immunohistochemistry, Memory, Mice, Inbred C57BL, Physical Conditioning, Animal, Ribonucleotides, Spatial Behavior, Thiazoles, Maze Learning, PPAR delta, Mice, Neurogenesis
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