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The Genetic Control of Tertiary Protein Structure: Studies With Model Systems
Abstract
At the present time it is generally assumed that most, if not all, proteins possess well-defined structures. This assumption is based on several kinds of evidence: (1) the finding that many proteins have unique amino acid sequences, with specific intrachain disulfide bonds; (2) the ability to determine the three-dimensional configuration (tertiary structure) and, in some instances, even portions of the amino acid sequence of proteins such as myoglobin and hemoglobin by X-ray crystallographic methods; (3) the highly reproducible physical-chemical properties of a large number of proteins; and (4) the great degree of configurational specificity which appears necessary for enzymic activity. When one considers the complexity of the tertiary structure of a “native” protein, it seems reasonable to inquire into how a newly-made protein arrives at its three-dimensional configuration.
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Citations
Cited by
Principles that Govern the Folding of Protein Chains
Anfinsen, C. B. (1973) · Science · doi:10.1126/science.181.4096.223 · Cited by 7,096
Self-citationSelf‐Assembly in Natural and Unnatural Systems
Philp, D., & Stoddart, J. F. (1996) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199611541 · Cited by 2,115
The coming of age of de novo protein design
Huang, P.-S., Boyken, S. E., & Baker, D. (2016) · Nature · doi:10.1038/nature19946 · Cited by 1,478
Combining evolutionary information and neural networks to predict protein secondary structure
Rost, B., & Sander, C. (1994) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.340190108 · Cited by 1,452
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Meier, J., Rao, R., Verkuil, R., Liu, J., Sercu, T., & Rives, A. (2021) · doi:10.1101/2021.07.09.450648 · Cited by 635
Metadata
- Authors
- Epstein, C. J., Goldberger, R. F., & Anfinsen, C. B.
- Venue
- Cold Spring Harbor Symposia on Quantitative Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1963-01-01
- Volume
- 28
- Issue
- 0
- Pages
- 439-449
- ISSN
- 0091-7451 (ISSN-L)
- 1943-4456
- OpenAlex
- W2326282683
- Cited by
- 303
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- closed
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- Epstein, C. J., Goldberger, R. F., & Anfinsen, C. B. (1963). The Genetic Control of Tertiary Protein Structure: Studies With Model Systems. Cold Spring Harbor Symposia on Quantitative Biology. https://doi.org/10.1101/sqb.1963.028.01.060
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