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Isolation of Sarcoplasmic Reticulum Proteins
Abstract
The sarcoplasmic reticulum is specialized for binding and release of Ca++ (Ebashi et al., 1969; Martonosi, 1971; Weber, 1966). Because of this specialization, the membrane contains relatively few proteins (Martonosi, 1969; Martonosi and Halpin, 1971; MacLennan, 1970; MacLennan and Wong, 1971; MacLennan et al., 1971), and, as would be expected, many of these proteins interact strongly with Ca++ ion. We are engaged in a program of resolution, characterization, and reconstitution of proteins involved in the Ca++ transport process of sarcoplasmic reticulum (MacLennan, 1970; MacLennan et al., 1971; MacLennan and Wong, 1971). Resolution and characterization have, of necessity, preceded reconstitution, and we have only recently turned our attention to reassembly of the Ca++ transport system from isolated components.
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Cited by
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Krysko, D. V., Garg, A. D., Kaczmarek, A., Krysko, O., Agostinis, P., & Vandenabeele, P. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3380 · Cited by 3,223
Tada, M., Kirchberger, M., & Katz, A. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)41650-5 · Cited by 434
The Regulation of Intracellular Calcium
Carafoli, E., & Crompton, M. (1978) · Current Topics in Membranes and Transport · doi:10.1016/s0070-2161(08)60835-7 · Cited by 409
Isolation of a High Affinity Calcium-binding Protein from Sarcoplasmic Reticulum
Ostwald, T. J., & MacLennan, D. H. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43026-3 · Cited by 395
Self-citationExpression of calreticulin in Escherichia coli and identification of its Ca2+ binding domains.
Baksh, S., & Michalak, M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54661-5 · Cited by 360
Metadata
- Authors
- MacLennan, D. H., Yip, C. C., Iles, G. H., & Seeman, P.
- Venue
- Cold Spring Harbor Symposia on Quantitative Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1973-01-01
- Volume
- 37
- Issue
- 0
- Pages
- 469-477
- ISSN
- 0091-7451 (ISSN-L)
- 1943-4456
- OpenAlex
- W2111809871
- Cited by
- 190
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- closed
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- MacLennan, D. H., Yip, C. C., Iles, G. H., & Seeman, P. (1973). Isolation of Sarcoplasmic Reticulum Proteins. Cold Spring Harbor Symposia on Quantitative Biology. https://doi.org/10.1101/sqb.1973.037.01.058
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