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Cytogenetic Analysis by In Situ Hybridization with Fluorescently Labeled Nucleic Acid Probes
Abstract
The ability to detect cytogenetic abnormalities has increased as improved methods for chromosome identification have been developed. Banding techniques (Casperson et al. 1968; Yunis 1981) now allow identification of all human chromosomes as well as detection of a broad spectrum of structural and numerical chromosome aberrations. However, banding analysis has important limitations. It requires preparation of high-quality metaphase spreads and the attendant cell culture; it is not easily automated; and it requires time-consuming work by skilled observers. These limitations affect the application of banding analysis in a variety of clinical and experimental settings. Prenatal detection of aberrations is slow and laborious because of the cell culture and scoring process. Quantitative analysis of the frequency of translocated chromosomes for biological dosimetry is also hampered by the lengthy scoring process. Tumor cytogenetic analysis is limited by the difficulty of preparing high-quality metaphase spreads that are representative of the tumorigenic cells in the...
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Citations
Cited by
Lichter, P., Cremer, T., Borden, J., Manuelidis, L., & Ward, D. C. (1988) · Human Genetics · doi:10.1007/bf01790090 · Cited by 1,160
CRISPR/Cas9 in Genome Editing and Beyond
Wang, H., La Russa, M., & Qi, L. S. (2016) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060815-014607 · Cited by 1,110
Macromolecular Domains within the Cell Nucleus
Spector, D. L. (1993) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.09.110193.001405 · Cited by 601
Reconstruction of genomic rearrangements in great apes and gibbons by chromosome painting.
Jauch, A., Wienberg, J., Stanyon, R., Arnold, N., Tofanelli, S., Ishida, T., & Cremer, T. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.18.8611 · Cited by 310
Metadata
- Authors
- Pinkel, D., Gray, J. W., Trask, B., van den Engh, G., Fuscoe, J., & van Dekken, H.
- Venue
- Cold Spring Harbor Symposia on Quantitative Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1986-01-01
- Volume
- 51
- Issue
- 0
- Pages
- 151-157
- ISSN
- 0091-7451 (ISSN-L)
- 1943-4456
- OpenAlex
- W2121591701
- Cited by
- 285
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- closed
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- Pinkel, D., Gray, J. W., Trask, B., van den Engh, G., Fuscoe, J., & van Dekken, H. (1986). Cytogenetic Analysis by In Situ Hybridization with Fluorescently Labeled Nucleic Acid Probes. Cold Spring Harbor Symposia on Quantitative Biology. https://doi.org/10.1101/sqb.1986.051.01.018
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