Cellular and Molecular Biology of Lipoprotein Metabolism: Characterization of Lipoprotein Receptor-Ligand Interactions
Abstract
The apolipoproteins (apo-) regulate the metabolism of the various plasma lipoproteins and mediate the interaction of lipoproteins with specific lipoprotein receptors of cells (for review, see Mahley and Innerarity 1983; Mahley et al. 1984). Whole-body cholesterol homeostasis is regulated by the expression of lipoprotein receptors, which are important in determining lipoprotein and cholesterol concentrations in the plasma.
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The putative α-helix (residues 131-150) is rich in basic amino acids that are thought to provide direct ionic interaction with the acidic residues within the ligand binding domain of the LDL receptor.
“In contrast, the mutations of both apoE3(112 Cys→Arg, 142 Arg→Cys) (10) and apoE1-Harrisburg(146 Lys→Glu) (11) occur within a putative α-helix (residues 131-150) (25), which is rich in basic amino acids that are thought to provide direct ionic interaction with the acidic residues within the ligand binding domain of the LDL receptor (31).”
From Apolipoprotein E3-Leiden contains a seven-amino acid insertion that is a tandem repeat of residues 121–127 (1989) · cites this paper as [31]
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Apolipoprotein E: Structure-Function Relationships
Weisgraber, K. H. (1994) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60642-7 · Cited by 830 · see citing works
Self-citationWardell, M. R., Weisgraber, K. H., Havekes, L. M., & Rall, S. C. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)30067-5 · Cited by 80 · see citing works
Self-citationMarques, M. A., Owens, P. A., & Crutcher, K. A. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:24:1:073 · Cited by 29 · see citing works
- Authors
- Mahley, R. W., Innerarity, T. L., Weisgraber, K. H., Rall, S. C., Hui, D. Y., Lalazar, A., Boyles, J. K., Taylor, J. M., & Levy-Wilson, B.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Cold Spring Harbor Symposia on Quantitative Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1986-01-01
- Volume
- 51
- Issue
- 0
- Pages
- 821-828
- ISSN
- 0091-7451 (ISSN-L)
- 1943-4456
- OpenAlex
- W2165219153
- Cited by
- 22
- References
- 0
- Citations by year
- 2014: 1
- Type
- posted content
- Language
- en
- Open access
- closed
- Locations
- Cold Spring Harbor Symposia on Quantitative Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- lipoprotein metabolism, apolipoproteins, lipoprotein receptors, ligand-receptor interactions, cholesterol homeostasis, serum lipoproteins, receptor expression
- MeSH terms
- Amino Acid Sequence, Apolipoproteins B, Apolipoproteins E, Humans, Kinetics, Mutation, Receptors, Cell Surface, Genetic Variation, Receptors, Lipoprotein
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