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The Genetics of Programmed Cell Death in the Nematode Caenorhabditis elegans
Abstract
Cancerous growth often results from an increased rate of cell proliferation caused by the abnormal activation of a signal transduction pathway that normally stimulates cell division only in response to growth factor signals; many of the proto-oncogenes that have been characterized function in or respond to such intercellular signaling pathways (for review, see Cooper 1990). Recent findings indicate that cancerous growth also can result from a decreased rate of cell loss. The most striking example is provided by human B-cell follicular lymphomas. These cancers are often associated with t(14;18) chromosomal translocations that cause the proto-oncogene bcl-2 (bcl, B cell lymphoma), normally located on chromosome 18, to be adjacent to and regulated by an enhancer of the immunoglobulin heavy-chain locus, normally located on chromosome 14 (Bakhshi et al. 1985; Cleary and Sklar 1985; Tsujimoto et al. 1985). The resulting overexpression of a normal Bcl-2 protein in the B-cell lineage leads to...
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Cited by
Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80434-1 · Cited by 7,289
Zou, H., Henzel, W. J., Liu, X., Lutschg, A., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80501-2 · Cited by 3,145
Cytochrome C -Mediated Apoptosis
Jiang, X., & Wang, X. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073706 · Cited by 1,357
Bossy‐Wetzel, E., Newmeyer, D. D., & Green, D. R. (1998) · The EMBO Journal · doi:10.1093/emboj/17.1.37 · Cited by 1,225
A guide to cell death pathways
Yuan, J., & Ofengeim, D. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00689-6 · Cited by 933
Metadata
- Authors
- Horvitz, H. R., Shaham, S., & Hengartner, M. O.
- Venue
- Cold Spring Harbor Symposia on Quantitative Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1994-01-01
- Volume
- 59
- Issue
- 0
- Pages
- 377-385
- ISSN
- 0091-7451 (ISSN-L)
- 1943-4456
- OpenAlex
- W1994081180
- Cited by
- 193
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- closed
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- Horvitz, H. R., Shaham, S., & Hengartner, M. O. (1994). The Genetics of Programmed Cell Death in the Nematode Caenorhabditis elegans. Cold Spring Harbor Symposia on Quantitative Biology. https://doi.org/10.1101/sqb.1994.059.01.042
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