PU.1, a Shared Transcriptional Regulator of Lymphoid and Myeloid Cell Fates
Abstract
The hematopoietic system develops from a self-renewing, pluripotent stem cell (HSC) that generates a hierarchical array of developmental intermediates consisting ofmultipotent and lineage-committed progenitors that differentiate into erythrocytes, megakaryocytes, and cells ofthe innate and adaptive immune system. The latter include macrophages, neutrophils, mast cells, and B and Tlymphocytes. Multipotent progenitors represent intermediates between the HSC and the progenitor cells that arecommitted to a defined lineage. The identity and hierarchical relationships of the multipotent progenitors remainto be fully elucidated...
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PU.1 action is important or indispensable for sustained generation of all known hematopoietic precursors with lymphoid developmental potentials.
“its action is also important or indispensable for sustained generation of all known hematopoietic precursors that have lymphoid developmental potentials (1–9).”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [1]
PU.1 is upregulated at the transcriptional and protein levels in HSC by chronic inflammatory signals such as IL-1β.
“We and others have previously shown that the myeloid ‘master regulator’ transcription factor PU.1 (DeKoter et al., 1998; Singh et al., 1999) is upregulated at the transcriptional and protein levels in HSC by chronic inflammatory signals such as the pro-inflammatory cytokine IL-1β (Algeciras-Schimnich et al., 2003; Pietras et al., 2016; Hernandez et al., 2020; Rabe et al., 2020; Chavez et al., 2021”
From PU.1 is required to restrain myelopoiesis during chronic inflammatory stress (2023) · cites this paper as Singh et al., 1999
PU.1 plays important roles in establishing the functional properties of mature myeloid cells.
“PU.1 also plays important roles in establishing the functional properties of mature myeloid cells (Singh et al., 1999).”
From PU.1 is required to restrain myelopoiesis during chronic inflammatory stress (2023) · cites this paper as Singh et al., 1999
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References 25 · Cited by 66
- Authors
- SINGH, H., DEKOTER, R. P., & WALSH, J. C.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Cold Spring Harbor Symposia on Quantitative Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-01-01
- Volume
- 64
- Issue
- 0
- Pages
- 13-20
- ISSN
- 0091-7451 (ISSN-L)
- 1943-4456
- OpenAlex
- W2063956269
- Cited by
- 66
- References
- 25
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2021: 3 · 2019: 4 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 2
- Type
- posted content
- Language
- en
- Open access
- closed
- Locations
- Cold Spring Harbor Symposia on Quantitative Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- PU.1, transcriptional regulation, hematopoiesis, hematopoietic stem cells, multipotent progenitors, lineage commitment, hematopoietic hierarchy
- MeSH terms
- Proto-Oncogene Protein Spi-1, Animals, Bone Marrow Cells, Cell Differentiation, DNA-Binding Proteins, Hematopoiesis, Hematopoietic Stem Cells, Humans, Lymphocytes, Macrophages, Mast Cells, Models, Biological, Mutation, Neutrophils, Proto-Oncogene Proteins, Proto-Oncogenes, Transcription Factors, Trans-Activators, Interleukin-7, Receptors, Cytokine, GATA2 Transcription Factor
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