SIRT3 Regulates Mitochondrial Protein Acetylation and Intermediary Metabolism

Hirschey, M. D., Shimazu, T., Huang, J.- Y., Schwer, B., Verdin, E.·2011·Cold Spring Harbor Symposia on Quantitative Biology

Cited by (182)

Items 101–182 of 182

  1. Mitochondrial Dysfunction and Metabolic Disturbances Induced by Viral Infections
    Sandra Pérez, Monika Beck Gooz, Eduardo N. Maldonado · 2024 · Cells
  2. Sirtuin 3 attenuates amyloid-β induced neuronal hypometabolism
    Junxiang Yin, Shiping Li, Megan Nielsen, Tanner Carcione, Winnie S. Liang, Jiong Shi · 2018 · Aging
  3. Metabolic syndrome exacerbates amyloid pathology in a comorbid Alzheimer's mouse model
    Alpna Tyagi, Carol Mirita, Nadine Taher, Iman Shah, Emily Moeller, Anit Tyagi, Thomas Chong, Subbiah Pugazhenthi · 2020 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  4. Platycodon grandiflorum A. De Candolle Ethanolic Extract Inhibits Adipogenic Regulators in 3T3-L1 Cells and Induces Mitochondrial Biogenesis in Primary Brown Preadipocytes
    Hye‐Lin Kim, Jinbong Park, Hyewon Park, Yunu Jung, Dong‐Hyun Youn, JongWook Kang, Mi‐Young Jeong, Jae‐Young Um · 2015 · Journal of Agricultural and Food Chemistry
  5. Causes and Consequences of A Glutamine Induced Normoxic HIF1 Activity for the Tumor Metabolism
    Matthias Kappler, Ulrike Pabst, Claus Weinholdt, Helge W. Taubert, Swetlana Rot, Tom Kaune, Johanna Kotrba, Martin Porsch, Antje Güttler, Matthias Bache et al. · 2019 · International Journal of Molecular Sciences
  6. Decoding allosteric communication pathways in protein lysine acetyltransferase
    Ashfaq Ur Rehman, Mueed Ur Rahman, Shaoyong Lu, Hao Liu, Jiayi Li, Taaha Arshad, Abdul Wadood, Ho Leung Ng, Haifeng Chen · 2020 · International Journal of Biological Macromolecules
  7. Who Rules the Cell? An Epi-Tale of Histone, DNA, RNA, and the Metabolic Deep State
    Jeffrey Leung, Valérie Gaudin · 2020 · Frontiers in Plant Science
  8. Post-translational lysine ac(et)ylation in health, ageing and disease
    Anna‐Theresa Blasl, Sabrina Schulze, Chuan Qin, Leonie G. Graf, Robert Vogt, Michael Lammers · 2021 · Biological Chemistry
  9. Acetylation in Mitochondria Dynamics and Neurodegeneration
    Jaylyn Waddell, Aditi Banerjee, Tibor Kristián · 2021 · Cells
  10. Mitochondrial Acetylation and Genetic Models of Parkinson's Disease
    Georg W. J. Auburger, Suzana Gispert, Marina Jendrach · 2014 · Progress in molecular biology and translational science
  11. SIRT3 as a Regulator of Non-alcoholic Fatty Liver Disease
    Eun-Hee Cho · 2014 · Journal of Lifestyle Medicine
  12. Sirtuins as Modifiers of Huntington's Disease (HD) Pathology
    Sin Hui Neo, Bor Luen Tang · 2017 · Progress in molecular biology and translational science
  13. Global Lysine Acetylome Analysis of Desiccated Somatic Embryos of Picea asperata
    Yan Xia, Danlong Jing, Lisheng Kong, Jianwei Zhang, Fangqun Ouyang, Hanguo Zhang, Junhui Wang, Shougong Zhang · 2016 · Frontiers in Plant Science
  14. Sirtuin 3 Mediates Tau Deacetylation
    Shiping Li, Junxiang Yin, Megan Nielsen, Thomas G. Beach, Li Guo, Jiong Shi · 2019 · Journal of Alzheimer s Disease
  15. A review on SIRT3 and its natural small molecule activators as a potential Preventive and therapeutic target
    Yuanyuan Liu, Haidong Wei, Jianhong Li · 2023 · European Journal of Pharmacology
  16. Doxorubicin induced cardio toxicity through sirtuins mediated mitochondrial disruption
    Nisar Ahmad, Arfan Ullah, Peng Chu, Wenzhang Tian, Zeyao Tang, Zhaolin Sun · 2022 · Chemico-Biological Interactions
  17. Metformin ameliorates insulin resistance in L6 rat skeletal muscle cells through upregulation of SIRT3
    Song Yuping, Shi Jingli, Ying Wu, Han Chong, Zou Junjie, Shi Yong-quan, Liu Zhimin · 2014 · Chinese Medical Journal
  18. Osteoclasts control endochondral ossification via regulating acetyl-CoA availability
    Daizhao Deng, Xianming Liu, Wenlan Huang, Sirui Yuan, Genming Liu, Shanshan Ai, Yijie Fu, Haokun Xu, Xinyi Zhang, Shihai Li et al. · 2024 · Bone Research
  19. Metabolism and chromatin dynamics in health and disease
    Hanah Rodriguez, Haloom Rafehi, Mrinal R. Bhave, Assam El‐Osta · 2016 · Molecular Aspects of Medicine
  20. Detection of Insertions/Deletions Within SIRT1, SIRT2 and SIRT3 Genes and Their Associations with Body Measurement Traits in Cattle
    Yunyun Jin, Qing Yang, Jiayang Gao, Qi Tang, Bo Duan, Ting Yue Yu, Xinglei Qi, Jiming Liu, Rongmin Wang, Ruihua Dang et al. · 2018 · Biochemical Genetics
  21. SIRT3, a metabolic target linked to ataxia-telangiectasia mutated (ATM) gene deficiency in diffuse large B-cell lymphoma
    Kavita Bhalla, Sausan M. Jaber, Kayla Reagan, Arielle Hamburg, Karen F. Underwood, Aditya Jhajharia, Maninder Singh, Binny Bhandary, Shambhu Bhat, Nahid M. Nanaji et al. · 2020 · Scientific Reports
  22. Sirt3 deficiency induced down regulation of insulin degrading enzyme in comorbid Alzheimer’s disease with metabolic syndrome
    Alpna Tyagi, Musa Musa, Wladimir Labeikovsky, Subbiah Pugazhenthi · 2022 · Scientific Reports
  23. Relationship of Single Nucleotide Polymorphisms and Haplotype Interaction of Mitochondrial Unfolded Protein Response Pathway Genes with Head and Neck Cancer
    Malik Waqar Ahmed, Ishrat Mahjabeen, Shazma Gul, Anum Khursheed, Azhar Mehmood, Mahmood Akhtar Kayani · 2019 · Future Oncology
  24. Metabolic Effects of Caloric Restriction
    Dudley W. Lamming, Rozalyn M. Anderson · 2014 · Wiley eBooks
  25. Brain ethanol metabolism and mitochondria.
    Jaylyn Waddell, Mary C. McKenna, Tibor Kristián · 2022 · PubMed
  26. Unraveling the mechanism of quercetin alleviating BHPF-induced apoptosis in epithelioma papulosum cyprini cells: SIRT3-mediated mitophagy
    Shasha Chen, Yidan Wang, Kai Chen, Xinyue Xing, Qihang Jiang, Tong Xu · 2024 · Fish & Shellfish Immunology
  27. Characterizing age-related changes in intact mitochondrial proteoforms in murine hearts using quantitative top-down proteomics
    Andrea Ramírez‐Sagredo, Anju Teresa Sunny, Kellye A. Cupp‐Sutton, Trishika Chowdhury, Zhitao Zhao, Si Wu, Ying Ann Chiao · 2024 · Clinical Proteomics
  28. Effect of acute cold exposure on cardiac mitochondrial function: role of sirtuins
    Mithra Sudha Mohan, S. S. Aswani, N S Aparna, Puthenpura T. Boban, Perumana R. Sudhakaran, K. Saja · 2023 · Molecular and Cellular Biochemistry
  29. Impact of Lysine Succinylation on the Biology of Fungi
    John Adejor, Elisabeth Tumukunde, Guoqi Li, Hong Lin, Rui Xie, Shihua Wang · 2024 · Current Issues in Molecular Biology
  30. Hepatic steatosis is associated with dysregulated cholesterol metabolism and altered protein acetylation dynamics in chickens
    Xiaoli Guo, Qianqian Zhou, Jiaming Jin, Fangren Lan, Chaoliang Wen, Junying Li, Ning Yang, Congjiao Sun · 2023 · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
  31. Role of acetylation in nonalcoholic fatty liver disease: a focus on SIRT1 and SIRT3
    Fatiha Nassir · 2020 · Exploration of Medicine
  32. POLG mutations lead to abnormal mitochondrial remodeling during neural differentiation of human pluripotent stem cells via SIRT3/AMPK pathway inhibition
    Anbin Chen, Cecilie Katrin Kristiansen, Lena Elise Høyland, Mathias Ziegler, Jian Wang, Gareth J. Sullivan, Xingang Li, Laurence Albert Bindoff, Kristina Xiao Liang · 2022 · Cell Cycle
  33. Perturbed Brain Glucose Metabolism Caused by Absent SIRT3 Activity
    Tibor Kristián, Arman J. Karimi, Adam D. Fearnow, Jaylyn Waddell, Mary C. McKenna · 2021 · Cells
  34. GATA3 ameliorates melanocyte injuries in vitiligo through SIRT3‐mediated HMGB1 deacetylation
    Xiaojuan Nie, Baozhen Hao, Ben‐Li Zhang, Yuan‐Yuan Li · 2022 · The Journal of Dermatology
  35. Aberrant Decrease of the Endogenous SIRT3 and Increases of Acetylated Proteins in Scrapie-Infected Cell Line SMB-S15 and in the Brains of Experimental Mice
    Adalaiti Maimaitiming, Kang Xiao, Chao Hu, Jia Chen, Xuehua Yang, Donghua H. Zhou, Liping Gao, Xiao‐Ping Dong, Qi Shi · 2019 · ACS Chemical Neuroscience
  36. Histidine triad nucleotide-binding protein 2 attenuates metabolic dysfunction-associated steatotic liver disease through NAD+-dependent sirtuin-3 activation
    Qinqiu Wang, Yanjun Guo, Shenghui Chen, Zhening Liu, Xinyu Wang, Hangkai Huang, Qi‐En Shen, Ling Yang, Meng Li, Youming Li et al. · 2025 · Experimental & Molecular Medicine
  37. MnSOD non-acetylation mimic knock-in mice exhibit dilated cardiomyopathy
    Joseph R. Schell, Sung‐Jen Wei, Jun Zhang, Rolando Trevino, Wan Hsi Chen, Leonardo Aguilar, Wei Qian, Cole W. Corbett, Haiyan Jiang, Felix F Dong et al. · 2025 · Free Radical Biology and Medicine
  38. Polyphenols and Exercise in Mitochondrial Biogenesis: Focus on Age-Related CNS Disorders
    Junbiao Tu · 2025 · Molecular Neurobiology
  39. The neuroprotective effects of SFGDI on sirtuin 3-related oxidative stress by regulating the Sirt3/SOD/ROS pathway and energy metabolism in BV2 cells
    Zhiqiang Lu, Siqi Shen, Songyi Lin · 2024 · Food & Function
  40. Sirt3 Regulates Response to Oxidative Stress by Interacting with BER Proteins in Colorectal Cancer
    Jacek Kabziński, Anna Walczak, Ireneusz Majsterek · 2022 · Genetics Research
  41. Protein Lysine Acetylation: Grease or Sand in the Gears of β-Cell Mitochondria?
    Jaime Santo Domingo, Loı̈c Dayon, Andreas Wiederkehr · 2019 · Journal of Molecular Biology
  42. Back to the Future: Molecular Biology Meets Metabolism
    Steven Lanier McKnight · 2011 · Cold Spring Harbor Symposia on Quantitative Biology
  43. Cellular and molecular biology of posttranslational modifications in cardiovascular disease
    Li Zhu, Yongping Liu, Yuting Huang, Zijun Zhou, Jianfeng Liu, Li-Ming Yu, Huishan Wang · 2024 · Biomedicine & Pharmacotherapy
  44. Jabuticaba [Plinia trunciflora (O. Berg) Kausel] Protects Liver of Diabetic Rats Against Mitochondrial Dysfunction and Oxidative Stress Through the Modulation of SIRT3 Expression
    Caroline Calloni, Luana Soares Martínez, Daniela Franciele Gil, Douglas Machado da Silva, Matheus Parmegiani Jahn, Mirian Mendonça Salvador · 2021 · Frontiers in Physiology
  45. Retracted: Mitochondrial protein acetylation mediates nutrient sensing of mitochondrial protein synthesis and mitonuclear protein balance
    Antonella Di Domenico, Annette Hofer, Federica Tundo, Tina Wenz · 2014 · IUBMB Life · Retracted
  46. Orchestration of Mitochondrial Function and Remodeling by Post-Translational Modifications Provide Insight into Mechanisms of Viral Infection
    Ji Woo Park, Matthew D. Tyl, Ileana M. Cristea · 2023 · Biomolecules
  47. A High-Fat and High-Fructose Diet Exacerbates Liver Dysfunction by Regulating Sirtuins in a Murine Model
    Zehuan Ding, Jian Zhang, Mahua Choudhury · 2024 · Life
  48. The role of sirtuins in intervertebral disc degeneration: Mechanisms and therapeutic potential
    Heng Tu, Qian Gao, Yumeng Zhou, Peng Li, Dan Wu, Demao Zhang, Jing Yang · 2024 · Journal of Cellular Physiology
  49. Effect of regional muscle location but not adiposity on mitochondrial biogenesis-regulating proteins
    Jesús Gustavo Ponce‐González, Ignacio Ara, Steen Larsen, Borja Guerra, José A. L. Calbet, Jørn Wulff Helge · 2015 · European Journal of Applied Physiology
  50. Candidates for reproductive biomarkers: Protein phosphorylation and acetylation positively related to selected parameters of boar spermatozoa quality
    Peifei Li, Qiangzhen Yang, Sisi Li, Hao Sun, Huan Liu, Bushe Li, Qingwei Cui, Xinhong Li · 2018 · Animal Reproduction Science
  51. Deacetylation by SIRT3 Relieves Inhibition of Mitochondrial Protein Function
    Peter Chhoy, Kristin A. Anderson, Kathleen A. Hershberger, Frank K. Huynh, Angelical S. Martin, Eoin McDonnell, Brett S. Peterson, Laura A. Starzenski, Donald S. Backos, Kristofer S. Fritz et al. · 2016 · Springer eBooks
  52. Potential biomarkers of early diagnosis of Alzheimer’s disease
    Anna Nicolaevna Bogolepova, Ekaterina Vladimirovna Makhnovich, Е. А. Коваленко, N A Osinovskaya · 2022 · S S Korsakov Journal of Neurology and Psychiatry
  53. SIRT3 Acetylation Regulates Mitophagy to Alleviate Deoxynivalenol-Induced Apoptosis in Porcine Alveolar Macrophages Cells
    Peng Fan, Huidan Deng, Wang Ya, Zhihua Ren, Junliang Deng · 2025 · International Journal of Molecular Sciences
  54. Exploring new benefits of vitamin A: alleviating hypoxia-induced mitochondrial stress and mitophagy in the gills of adult grass carp (Ctenopharyngodon idellus)
    Hua Cheng, Lin Feng, Pei Wu, Yang Liu, Yao-Bin Ma, Hongmei Ren, Xiao‐Wan Jin, Xiao‐Qiu Zhou, Wei‐Dan Jiang · 2025 · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
  55. PrPSc Inhibition and Cellular Protection of DBL on a Prion-Infected Cultured Cell via Multiple Pathways
    Wei Yang, Cao Chen, Jia Chen, Ying Xia, Chao Hu, Lin Wang, Yue-Zhang Wu, Qi Shi, Zhibao Chen, Xiao‐Ping Dong · 2022 · Molecular Neurobiology
  56. Sirtuins and Aging
    Carles Cantó, Riekelt H. Houtkooper · 2016 · Springer eBooks
  57. Polyploidy in Liver Function, Mitochondrial Metabolism, and Cancer
    Evan R. Delgado, Elizabeth C. Stahl, Nairita Roy, Patrick D. Wilkinson, Andrew W. Duncan · 2020 · Wiley eBooks
  58. Mitochondrial brain proteome acetylation levels and behavioural responsiveness to amphetamine are altered in mice lacking Sirt3
    Elena Sidorova‐Darmos, Merrick S. Fallah, Richard Logan, Lin Cheng, James H. Eubanks · 2022 · Frontiers in Physiology
  59. SIRT3 ameliorates hepatic inflammation, oxidative stress, and fibrosis in HFD- or MCD diet-fed mice
    Huifang Lv, Wenyue Sun, Cuixia Tian, Chunyong Bian, Zhongting Lu, Xin Guo · 2026 · The Journal of Nutritional Biochemistry
  60. Acute hypoxia induces liver mitochondrial and endoplasmic reticulum stress in adult grass carp (Ctenopharyngodon idella): Palliative effects of vitamin A
    Hua Cheng, Xiaoqiu Zhou, Lin Feng, Pei Wu, Yang Liu, Yaobin Ma, Jiayong Tang, Fali Wu, Lu Zhang, Haifeng Mi et al. · 2026 · Animal nutrition
  61. Identification of TgElp3 as an essential, tail-anchored mitochondrial lysine acetyltransferase in the protozoan pathogen toxoplasma gondii
    Krista L. Stilger · 2014
  62. Reciprocal Crosstalk Between Angiogenesis and Metabolism
    Gaëlle Laurent, Fatima Mechta‐Grigoriou · 2014 · Springer eBooks
  63. Current Models of Fatty Liver Disease; New Insights, Therapeutic Targets and Interventions
    Karen R. Jonscher, Kimberley D. Bruce · 2019 · Advances in experimental medicine and biology
  64. Mitochondrial Dysfunction and Oxidative Stress: Focusing on Cardiac Hypertrophy and Heart Failure
    Parmeshwar Bajirao Katare, Hina Lateef Nizami, Sanjay Kumar Banerjee · 2019 · Springer eBooks
  65. Identification of Sirt3 as an ‘Eraser’ for Histone Lysine Crotonylation Marks Using a Chemical Proteomics Approach
    Xiucong Bao · 2020 · Springer theses
  66. Critical Importance of the Perinatal Period in the Development of Obesity
    Peter Russell Baker, Jacob E. Friedman · 2014 · Springer eBooks
  67. Cloning and Characterization of Sirtuin3 (SIRT3)
    Andy W. C. Man, Bo Bai, Yu Wang · 2016 · Methods in molecular biology
  68. Regulation of SIRT1, SIRT3, PGC-1α, and LRP130 in Response to Energetic Stress in Human Skeletal Muscle
    Brittany A. Edgett · 2017 · QSpace (Queen's University Library)
  69. Introduction to Protein Posttranslational Modifications (PTMs)
    Xiucong Bao · 2020 · Springer theses
  70. Sirtuins in mechanistic target of rapamycin complex 1 signaling
    Jesús Burillo, Patricia Marqués, Beatriz Jiménez, Carlos González-Blanco, Manuel Benito, Carlos Guillén · 2021 · Elsevier eBooks
  71. Nutraceuticals for targeting NAD+ to restore mitochondrial function
    Antje Garten, Gareth Geoffrey Lavery · 2022 · Elsevier eBooks
  72. Potential Biomarkers for Early Diagnosis of Alzheimer’s Disease and Primary Open-Angle Glaucoma
    Anna Nicolaevna Bogolepova, Ekaterina Vladimirovna Makhnovich, Е. А. Коваленко, N A Osinovskaya · 2023 · Neuroscience and Behavioral Physiology
  73. Additional file 1 of Hepatic steatosis is associated with dysregulated cholesterol metabolism and altered protein acetylation dynamics in chickens
    Guo, Xiaoli, Qianqian Zhou, Jiaming Jin, Fangren Lan, Chaoliang Wen, Li, Junying, Yang, Ning, Sun, Congjiao · 2024 · Figshare
  74. Additional file 2 of Hepatic steatosis is associated with dysregulated cholesterol metabolism and altered protein acetylation dynamics in chickens
    Guo, Xiaoli, Qianqian Zhou, Jiaming Jin, Fangren Lan, Chaoliang Wen, Li, Junying, Yang, Ning, Sun, Congjiao · 2024 · Figshare
  75. Additional file 3 of Hepatic steatosis is associated with dysregulated cholesterol metabolism and altered protein acetylation dynamics in chickens
    Xiaoli Guo, Qianqian Zhou, Jiaming Jin, Fangren Lan, Chaoliang Wen, Li, Junying, Yang, Ning, Sun, Congjiao · 2024 · Figshare
  76. Glutathione-rich yeast extract improves alcohol-associated liver diseases through the improvement of mitochondrial dysfunction and oxidative stress by activating SIRT3
    Hao Han, Yanyang Han, YaJing Dong, Shuqi Ji, Xiaoman Wang, Yuantong Yu, Xingxing Che · 2026 · Journal of Agriculture and Food Research
  77. Alcohol-Mediated Cognitive Impairment Following Traumatic Brain Injury: Evidence for Cortical Mitochondrial Dysfunction
    Xavier R. Chapa‐Dubocq, Alejandra Jacotte-Simancas, Andrea Martinez-Santana, Michael C. Salling, Liz Simon, Scott Edwards, Patricia E. Molina · 2026 · Neurotrauma Reports
  78. Cardiac manifestations of inherited metabolic disease linked to cellular metabolism of vitamin B12 : study in two murine models of invalidation of Mtr and MMACHC genes
    Viola Jepchumba Kosgei · 2019
  79. The Effects of Exercise Combined with Pharmacotherapy on Body Composition and Metabolic Parameters in Overweight/Obese Adults: A Meta-Analysis and Network Pharmacology Study
    Tianhang Peng, Wanyuan Liang, Ju Wei, Ni Ding, Xiuqi Tang, Zike Zhang · 2026 · Diabetes Metabolic Syndrome and Obesity
  80. Sex-dependent differences in mitochondrial protein acetylation in metabolic condition, oxidative stress, vascular dysfunction, hypertension, and cardiovascular disease
    Anna Dikalova, Sergey Dikalov · 2026 · Clinical Science
  81. Post-translational modification-regulating biomaterials for regeneration
    Adilijiang Abudousu, Yunkai Tang, Baikun Liu, Lei Xiang, Zi Wang, Yue Li, Ding Zhao, Wenguo Cui · 2026 · Bioactive Materials
  82. BindingDB Entry 50042350: Sirtuins as emerging anti-parasitic targets.
    BindingDB · 2013 · UC San Diego