Nucleus Accumbens Modulation in Reward and Aversion
Open accessAbstract
The nucleus accumbens (NAc) is a key node of the brain's circuitry that is responsible for translating motivation into action. It has been implicated in playing critical roles in virtually all forms of adaptive and pathological motivated behaviors. It is subject to modulation by a broad array of inputs that influence NAc activity in complex ways that are still poorly understood. Here, we briefly review current knowledge about the behavioral consequences of NAc modulation, focusing on recent studies that use novel techniques developed and implemented over the last decade.
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The nucleus accumbens is critical to forming reward and aversion behaviors.
“Among these, the nucleus accumbens (NAc) is critical to forming reward and aversion behaviors [9].”
From The Impact of Social Media & Technology on Child and Adolescent Mental Health (2025) · cites this paper as [9]
Unlike dopamine release in the nucleus accumbens caused by optogenetic stimulation or administration of drugs of abuse, serotonin release in the nucleus accumbens is not acutely reinforcing.
“Importantly, unlike the release of DA in the NAc caused by optogenetic stimulation or administration of drugs of abuse [11,21,53,54], 5-HT release in the NAc is not acutely reinforcing [11,21,47] but see ref. [55].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [11]
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References 133 · Cited by 163
Research works printed but not linked: 1
- Nestler EJ, Hyman SE, Holtzman DM, Malenka RC. 2015 Molecular neuropharmacology—a foundation for clinical neuro-science, 3rd ed. McGraw-Hill Education, New York.
- Authors
- Klawonn, A. M., & Malenka, R. C.
- Affiliations
- Stanford Medicine (US)
- Venue
- Cold Spring Harbor Symposia on Quantitative Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2018
- Volume
- 83
- Pages
- 119-129
- ISSN
- 0091-7451 (ISSN-L)
- 1943-4456
- PMC
- PMC6650377
- OpenAlex
- W2911303760
- Cited by
- 163
- References
- 133
- Citations by year
- 2026: 29 · 2025: 44 · 2024: 26 · 2023: 21 · 2022: 11 · 2021: 16 · 2020: 12 · 2019: 3 · 2018: 1
- Type
- posted content
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Cold Spring Harbor Symposia on Quantitative Biology (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion, cc-by-nc)
- Funders
- Simons Foundation (305112)
- Simons Foundation Autism Research Initiative
- Knut och Alice Wallenbergs Stiftelse
- National Institute on Drug Abuse (DA 008227, DA042012, P01DA008227, P50DA042012)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nucleus accumbens, reward, aversion, motivation, motivated behavior, neural circuits, behavioral effects, neuromodulation
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