Anomalous dynamics of translocation

Abstract

We study the dynamics of the passage of a polymer through a membrane pore (translocation), focusing on the scaling properties with the number of monomers N. The natural coordinate for translocation is the number of monomers on one side of the hole at a given time. Commonly used models that assume Brownian dynamics for this variable predict a mean (unforced) passage time tau that scales as N2, even in the presence of an entropic barrier. In particular, however, the time it takes for a free polymer to diffuse a distance of the order of its radius by Rouse dynamics scales with an exponent larger than two, and this should provide a lower bound to the translocation time. To resolve this discrepancy, we perform numerical simulations with Rouse dynamics for both phantom (in space dimensions d=1 and 2), and self-avoiding (in d=2) chains. The results indicate that for large N, translocation times scale in the same manner as diffusion times, but with a larger prefactor that depends on the size of the hole. Such scaling implies anomalous dynamics for the translocation process. In particular, the fluctuations in the monomer number at the hole are predicted to be nondiffusive at short times, while the average pulling velocity of the polymer in the presence of a chemical-potential difference is predicted to depend on N.