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Origin of Entropy Convergence in Hydrophobic Hydration and Protein Folding
Open accessAbstract
An information theory model is used to construct a molecular explanation why hydrophobic solvation entropies measured in calorimetry of protein unfolding converge at a common temperature. The entropy convergence follows from the weak temperature dependence of occupancy fluctuations for molecular-scale volumes in water. The macroscopic expression of the contrasting entropic behavior between water and common organic solvents is the relative temperature insensitivity of the water isothermal compressibility. The information theory model provides a quantitative description of small molecule hydration and predicts a negative entropy at convergence. Interpretations of entropic contributions to protein folding should account for this result.
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Cited by
Water as an active constituent in cell biology
Ball, P. (2008) · Chemical Reviews · doi:10.1021/cr068037a · Cited by 2,177
Water structural transformation at molecular hydrophobic interfaces
Davis, J. G., Gierszal, K. P., Wang, P., & Ben-Amotz, D. (2012) · Nature · doi:10.1038/nature11570 · Cited by 587
Hydrophobic hydration from small to large lengthscales: Understanding and manipulating the crossover
Rajamani, S., Truskett, T. M., & Garde, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504089102 · Cited by 300
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Metadata
- Authors
- Garde, S., Hummer, G., García, A. E., Paulaitis, M. E., & Pratt, L. R.
- Venue
- Physical Review Letters
- Publisher
- American Physical Society (APS)
- Published
- 1996-12-09
- Volume
- 77
- Issue
- 24
- Pages
- 4966-4968
- ISSN
- 0031-9007 (ISSN-L)
- 1079-7114
- OpenAlex
- W2085806783
- Cited by
- 261
- References
- 0
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Origin of Entropy Convergence in Hydrophobic Hydration and Protein Folding. https://app.cochat.ai/papers/10.1103/physrevlett.77.4966
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- Garde, S., Hummer, G., García, A. E., Paulaitis, M. E., & Pratt, L. R. (1996). Origin of Entropy Convergence in Hydrophobic Hydration and Protein Folding. Physical Review Letters. https://doi.org/10.1103/physrevlett.77.4966
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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