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Hydrodynamic Focusing on a Silicon Chip: Mixing Nanoliters in Microseconds
Abstract
We describe the formation and control of nanoscale, submerged fluid jets. The focusing process necessary to achieve these small length scales is characterized experimentally and theoretically. Fast mixing is one important application of nanoscale fluid control: We demonstrate this with a continuous-flow mixer capable of mix times of less than $10\ensuremath{\mu}\mathrm{s}$ and sample consumption rates of nanoliters per second. This new technique facilitates the study of fast reaction kinetics on time scales unattainable with conventional mixing technology.
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Citations
Cited by
Microfluidic Platform for Controlled Synthesis of Polymeric Nanoparticles
Karnik, R., Gu, F., Basto, P., Cannizzaro, C., Dean, L., Kyei-Manu, W., Langer, R., & Farokhzad, O. C. (2008) · Nano Letters · doi:10.1021/nl801736q · Cited by 887
Millisecond Kinetics on a Microfluidic Chip Using Nanoliters of Reagents
Song, H., & Ismagilov, R. F. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0354566 · Cited by 693
Small-Angle X-ray Scattering of Polymers
Chu, B., & Hsiao, B. S. (2001) · Chemical Reviews · doi:10.1021/cr9900376 · Cited by 455
Evers, M. J. W., Kulkarni, J. A., van der Meel, R., Cullis, P. R., Vader, P., & Schiffelers, R. M. (2018) · Small Methods · doi:10.1002/smtd.201700375 · Cited by 332
Micro- and nanoparticles via capillary flows
Barrero, A., & Loscertales, I. G. (2007) · Annual Review of Fluid Mechanics · doi:10.1146/annurev.fluid.39.050905.110245 · Cited by 219
Metadata
- Authors
- Knight, J. B., Vishwanath, A., Brody, J. P., & Austin, R. H.
- Venue
- Physical Review Letters
- Publisher
- American Physical Society (APS)
- Published
- 1998-04-27
- Volume
- 80
- Issue
- 17
- Pages
- 3863-3866
- ISSN
- 0031-9007 (ISSN-L)
- 1079-7114
- OpenAlex
- W2059106681
- Cited by
- 887
- References
- 0
- FWCI
- 12.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Hydrodynamic Focusing on a Silicon Chip: Mixing Nanoliters in Microseconds. https://app.cochat.ai/papers/10.1103/physrevlett.80.3863
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- Knight, J. B., Vishwanath, A., Brody, J. P., & Austin, R. H. (1998). Hydrodynamic Focusing on a Silicon Chip: Mixing Nanoliters in Microseconds. Physical Review Letters. https://doi.org/10.1103/physrevlett.80.3863
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
