The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Sampling Rare Switching Events in Biochemical Networks
Open accessAbstract
Bistable biochemical switches are widely found in gene regulatory networks and signal transduction pathways. Their switching dynamics are difficult to study, however, because switching events are rare, and the systems are out of equilibrium. We present a simulation method for predicting the rate and mechanism of the flipping of these switches. We apply it to a genetic switch and find that it is highly efficient. The path ensembles for the forward and reverse processes do not coincide. The method is widely applicable to rare events and nonequilibrium processes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Multistability in the lactose utilization network of Escherichia coli
Ozbudak, E. M., Thattai, M., Lim, H. N., Shraiman, B. I., & van Oudenaarden, A. (2004) · Nature · doi:10.1038/nature02298 · Cited by 1,030
A positive-feedback-based bistable ‘memory module’ that governs a cell fate decision.
Xiong, W., & Ferrell, J. E. (2003) · Nature · doi:10.1038/nature02089 · Cited by 741
Cited by
Laio, A., & Gervasio, F. L. (2008) · Reports on Progress in Physics · doi:10.1088/0034-4885/71/12/126601 · Cited by 1,619
Obtaining reaction coordinates by likelihood maximization
Peters, B., & Trout, B. L. (2006) · The Journal of Chemical Physics · doi:10.1063/1.2234477 · Cited by 417
Homogeneous Ice Nucleation at Moderate Supercooling from Molecular Simulation
Sanz, E., Vega, C., Espinosa, J. R., Caballero-Bernal, R., Abascal, J. L. F., & Valeriani, C. (2013) · Journal of the American Chemical Society · doi:10.1021/ja4028814 · Cited by 334
Rohrdanz, M. A., Zheng, W., & Clementi, C. (2013) · Annual Review of Physical Chemistry · doi:10.1146/annurev-physchem-040412-110006 · Cited by 242
The RED scheme: Rate-constant estimation from pre-steady state weighted ensemble simulations
(2021) · doi:10.1063/5.0041278 · Cited by 20
Metadata
- Authors
- Allen, R. J., Warren, P. B., & ten Wolde, P. R.
- Venue
- Physical Review Letters
- Publisher
- American Physical Society (APS)
- Published
- 2005-01-06
- Volume
- 94
- Issue
- 1
- Pages
- 018104-018104
- ISSN
- 0031-9007 (ISSN-L)
- 1079-7114
- OpenAlex
- W2031952899
- Cited by
- 488
- References
- 2
- FWCI
- 7.84
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Sampling Rare Switching Events in Biochemical Networks. https://app.cochat.ai/papers/10.1103/physrevlett.94.018104
- The paper
- Allen, R. J., Warren, P. B., & ten Wolde, P. R. (2005). Sampling Rare Switching Events in Biochemical Networks. Physical Review Letters. https://doi.org/10.1103/physrevlett.94.018104
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
